This document discusses maternal sepsis, which is a life-threatening complication that affects over 60,000 women in the United States each year, resulting in around 2,000 deaths. Sepsis caused by infections is one of the leading causes of maternal mortality worldwide and may be preventable through increased awareness and prompt treatment. The new WHO definition classifies maternal sepsis as an organ dysfunction caused by infection during pregnancy, childbirth, or postpartum. Risk factors include procedures like cesarean sections and complications of delivery. Early identification through clinical signs, labs, and monitoring systems can help providers treat at-risk women more quickly and prevent sepsis. A multi-disciplinary approach in a maternal intensive care unit provides the best care for critically ill