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“Paolo Sotgiu” Institute for research in Quantitative & Quantum Psychiatry & Cardiology
Istituto “Paolo Sotgiu” per la ricerca in Psichiatria e Cardiologia Quantitativa e Quantistica

                                                   Director: Prof. Massimo Cocchi
summary of the experimental steps
Molecular Changes in Mood Disorders
             Marche Region
              Special Project

Project Coordinator: Prof. Franco Canestrari
Scientific Project Leader: Prof. Massimo Cocchi
Clinical Aspects
Dott. Raimondo Venanzini, Dott.ssa Raffaella Silvestri
Blood Chemistry Analysis
Dott. Massimo Valentini
Markers of Oxidative Stress
Dott. Serena Benedetti, Dott. Maria Chiara Tagliamone
Platelet Membrane Markers
Prof. Anna Rita Mastrogiacomo, Dott. Valerio Marconi,
Dott. Sabina Bucciarelli, Prof. Mark Rasenick
Gene Expression
Prof. Maria Stella Colomba, Prof. Armando Gregorini
B2    A      DEP      BIP

     0,205   -0,329   0,808
Serotonin
Subjects not treated
31
     0
         m
             ill
                io
                  n
                      ye
                           ar
                                s
                                    ag
                                         o
Post Syn
                                                  SNS
              serotonin
Membrane                            SSRI
viscosity
                        5-HTT    Pre Syn
                       Serotonin


                  Membrane
                  viscosity


                   Platelet                SSRI
      Serotonin




                              Serotonin




                   Osteoblast                           Osteoclast
C16:0                          C20:4




        The fulcrum of C18:2
Humans and Animals
Massimo Cocchi
Massimo Cocchi

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Massimo Cocchi

  • 1. “Paolo Sotgiu” Institute for research in Quantitative & Quantum Psychiatry & Cardiology Istituto “Paolo Sotgiu” per la ricerca in Psichiatria e Cardiologia Quantitativa e Quantistica Director: Prof. Massimo Cocchi
  • 2. summary of the experimental steps
  • 3. Molecular Changes in Mood Disorders Marche Region Special Project Project Coordinator: Prof. Franco Canestrari Scientific Project Leader: Prof. Massimo Cocchi Clinical Aspects Dott. Raimondo Venanzini, Dott.ssa Raffaella Silvestri Blood Chemistry Analysis Dott. Massimo Valentini Markers of Oxidative Stress Dott. Serena Benedetti, Dott. Maria Chiara Tagliamone Platelet Membrane Markers Prof. Anna Rita Mastrogiacomo, Dott. Valerio Marconi, Dott. Sabina Bucciarelli, Prof. Mark Rasenick Gene Expression Prof. Maria Stella Colomba, Prof. Armando Gregorini
  • 4. B2 A DEP BIP 0,205 -0,329 0,808
  • 7. 31 0 m ill io n ye ar s ag o
  • 8.
  • 9. Post Syn SNS serotonin Membrane SSRI viscosity 5-HTT Pre Syn Serotonin Membrane viscosity Platelet SSRI Serotonin Serotonin Osteoblast Osteoclast
  • 10.
  • 11. C16:0 C20:4 The fulcrum of C18:2