Ed Sheeran's song "Bloodstream" describes feelings of intoxication, loneliness, and regret. The lyrics tell of drinking alcohol to escape problems and fade away, with the chemicals burning in the singer's bloodstream. The song references scars on a broken-hearted lover and voices calling out, expressing a desire to free the mind from pain through substances. The music video shows three characters with troubled lives, depicting a woman with bruises trying to hide them, a man writing in a notebook next to a loved one's photo, and another alone by a campfire, paralleling the emotions in the lyrics.