Losartan
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Losartan drug profile
Losartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of stroke. It works by blocking angiotensin II receptors to lower blood pressure and improve blood flow. Common side effects include dizziness, upper respiratory infection, and back pain. It is available in tablet forms of 25mg, 50mg and 100mg and is usually taken once daily orally for hypertension or nephropathy in diabetic patients.
Profile on olmesartan
Describes a broad outline of market scenario on Olmesartan and its popular brand name in the Indian pharma industry
Olmesartan Medoxomil tablets
Lupin launches generic hypertension drug Olmesartan Medoxomil tablets in the US market. Olmesartan is an angiotensin receptor blocker used to treat high blood pressure. It works by relaxing blood vessels to allow blood to flow more easily. Lupin received FDA approval to launch generic versions of Daiichi Sankyo's branded hypertension drug Benicar, which had US sales of $681 million in July 2017. The key safety issues reported for Olmesartan are headache, influenza-like symptoms, and dizziness.
Oliset Olmesartan
Olmesartan medoxomil is an angiotensin II receptor antagonist which is used for the treatment of high blood pressure. An ester prodrug, it is completely and rapidly hydrolyzed to the active acid form. It is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents
Rosuvastatin final marketing plan
This document outlines a marketing plan for Rostin, a new rosuvastatin tablet being launched by South Asian Pharmaceuticals Limited. The objectives are to make Rostin a top-selling brand and highest prescribed product. The executive summary discusses the prevalence of cardiovascular disease and the benefits of statin drugs. It introduces Rostin as a new generation statin with an excellent safety profile. The situation analysis covers the target markets of hyperlipidemia, hypercholesterolemia, and coronary heart disease patients. It analyzes the market demographics, needs, trends, size and growth. The SWOT analysis identifies strengths such as positive brand growth, weaknesses like the need for more promotion, and threats from competing stat
Telmisartan
Telmisartan is a new angiotensin receptor blocker (ARB) that has several potential advantages over other ARBs. It has the strongest binding affinity to the AT1 receptor compared to other ARBs. This may provide stronger and longer-lasting blood pressure lowering effects. Telmisartan also has partial agonist effects on peroxisome proliferator-activated receptor gamma, which can improve insulin resistance and exert anti-inflammatory and anti-proliferative effects in the vasculature. Studies in animals and cells suggest Telmisartan may have insulin sensitizing effects and protect against diabetic complications by blocking upregulation of VEGF and AGE-RAGE protein expression in the retina. While more randomized clinical trials
drug-receptor relationship for valsartan
The document discusses the drug-receptor relationships of valsartan and lisinopril. It provides background on their indications, chemical properties, and classes. Valsartan is an angiotensin receptor blocker (ARB) that binds to and blocks the AT1 receptor, acting as an antagonist. Studies show valsartan has a dose-dependent response in lowering blood pressure and higher receptor occupancy than other ARBs. Further research discovered valsartan can also act as an inverse agonist by stabilizing the inactive state of the AT1 receptor. Lisinopril is an ACE inhibitor that works by inhibiting the angiotensin-converting enzyme and thus preventing the formation of angiotensin II
ARB in the management of Hypertension
ARBs (Angiotensin receptor blockers) are the most widely used anti hypertensive throughout the world. A solid knowledge related to ARB will make our practice more patients friendly & benefit will be maximum.
Recommended
Losartan drug profile
Losartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of stroke. It works by blocking angiotensin II receptors to lower blood pressure and improve blood flow. Common side effects include dizziness, upper respiratory infection, and back pain. It is available in tablet forms of 25mg, 50mg and 100mg and is usually taken once daily orally for hypertension or nephropathy in diabetic patients.
Profile on olmesartan
Describes a broad outline of market scenario on Olmesartan and its popular brand name in the Indian pharma industry
Olmesartan Medoxomil tablets
Lupin launches generic hypertension drug Olmesartan Medoxomil tablets in the US market. Olmesartan is an angiotensin receptor blocker used to treat high blood pressure. It works by relaxing blood vessels to allow blood to flow more easily. Lupin received FDA approval to launch generic versions of Daiichi Sankyo's branded hypertension drug Benicar, which had US sales of $681 million in July 2017. The key safety issues reported for Olmesartan are headache, influenza-like symptoms, and dizziness.
Oliset Olmesartan
Olmesartan medoxomil is an angiotensin II receptor antagonist which is used for the treatment of high blood pressure. An ester prodrug, it is completely and rapidly hydrolyzed to the active acid form. It is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents
Rosuvastatin final marketing plan
This document outlines a marketing plan for Rostin, a new rosuvastatin tablet being launched by South Asian Pharmaceuticals Limited. The objectives are to make Rostin a top-selling brand and highest prescribed product. The executive summary discusses the prevalence of cardiovascular disease and the benefits of statin drugs. It introduces Rostin as a new generation statin with an excellent safety profile. The situation analysis covers the target markets of hyperlipidemia, hypercholesterolemia, and coronary heart disease patients. It analyzes the market demographics, needs, trends, size and growth. The SWOT analysis identifies strengths such as positive brand growth, weaknesses like the need for more promotion, and threats from competing stat
Telmisartan
Telmisartan is a new angiotensin receptor blocker (ARB) that has several potential advantages over other ARBs. It has the strongest binding affinity to the AT1 receptor compared to other ARBs. This may provide stronger and longer-lasting blood pressure lowering effects. Telmisartan also has partial agonist effects on peroxisome proliferator-activated receptor gamma, which can improve insulin resistance and exert anti-inflammatory and anti-proliferative effects in the vasculature. Studies in animals and cells suggest Telmisartan may have insulin sensitizing effects and protect against diabetic complications by blocking upregulation of VEGF and AGE-RAGE protein expression in the retina. While more randomized clinical trials
drug-receptor relationship for valsartan
The document discusses the drug-receptor relationships of valsartan and lisinopril. It provides background on their indications, chemical properties, and classes. Valsartan is an angiotensin receptor blocker (ARB) that binds to and blocks the AT1 receptor, acting as an antagonist. Studies show valsartan has a dose-dependent response in lowering blood pressure and higher receptor occupancy than other ARBs. Further research discovered valsartan can also act as an inverse agonist by stabilizing the inactive state of the AT1 receptor. Lisinopril is an ACE inhibitor that works by inhibiting the angiotensin-converting enzyme and thus preventing the formation of angiotensin II
ARB in the management of Hypertension
ARBs (Angiotensin receptor blockers) are the most widely used anti hypertensive throughout the world. A solid knowledge related to ARB will make our practice more patients friendly & benefit will be maximum.
Diuretics in hypertension 2015 by Dr Abhishek Rathore
Diuretics are recommended as first-line therapy for hypertension. The document discusses various classes of diuretics including loop diuretics, thiazides, thiazide-like agents, and potassium sparing agents. It provides examples of drugs in each class, their mechanisms of action, and sites of action. The document summarizes evidence from clinical trials showing that thiazide diuretics like chlorthalidone are more effective than hydrochlorothiazide at reducing cardiovascular events in hypertension. Indapamide is discussed as an alternative to hydrochlorothiazide with similar efficacy and fewer metabolic side effects. Combinations of ACE inhibitors or calcium channel blockers with diuretics are also effective antihy
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Atorvastatin is a statin drug used to lower cholesterol and prevent cardiovascular events. It works by inhibiting HMG-CoA reductase in the liver to decrease cholesterol production. It is well absorbed orally but has low bioavailability. The liver metabolizes atorvastatin through CYP3A4 enzymes and excretes it primarily in bile. Grapefruit juice and certain other drugs can interact with atorvastatin metabolism. Its medical uses include treating various dyslipidemias and preventing heart attacks and strokes in those with risk factors like diabetes. Side effects may include muscle pain or weakness.
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This document discusses various types of drugs used to treat hyperlipidemia. It begins by defining hyperlipidemia as a common disorder involving abnormal lipid metabolism that is a major cause of heart disease. It then describes several classes of antihyperlipidemic drugs, including HMG-CoA reductase inhibitors (statins), fibric acid derivatives, bile acid sequestrants, LDL oxidation inhibitors, and pyridine derivatives. For each class, examples of drugs are provided along with their mechanisms of action and effects on lipid levels.
Losart (Losartan)
This document provides a business plan for Losartan Potassium (Losartan) in Bangladesh for 2015. It summarizes hypertension prevalence data from various sources, showing about 20% of people in Bangladesh have hypertension. The cardiovascular drug market is growing at 11% annually and Losartan has a 29.24% share of the antihypertensive market. The objectives for 2015 are to achieve 10% sales growth, a 4.9% market share, and reach the number 3 market position for Losartan. The strategies proposed include increasing prescriptions from specialty physicians like cardiologists and improving performance in metro areas through targeted promotional initiatives.
Losartan Tablet 50 mg - Summary of Product Characteristics
Losartan Tablet is used to treat patients with high blood pressure, chronic heart failure, to protect the kidney in hypertensive type 2 diabetes.
Marketing Plan
- The document provides information on a marketing plan for the launch of the drug Esoz 20, which contains 20 mg of esomeprazole.
- Key details include the target market of Rs. 102.23 crores growing at 23.14% annually, a sales forecast projecting sales of Rs. 2.5 crores in the first year, and a promotional budget of Rs. 30 lakhs.
- The marketing strategies outlined include focusing on gastroenterologists, physicians, surgeons and gynecologists in metro and class 1/2 cities, with a sales force of 400 MRs planned to make 96,000 calls per month.
ACE INHIBITORS.pptx
This document provides information about ACE inhibitors, which are a class of drugs used to treat hypertension. It begins by defining hypertension and describing antihypertensive drugs. It then focuses on ACE inhibitors, explaining their mechanism of action in blocking the conversion of angiotensin I to angiotensin II, thereby reducing vasoconstriction and sodium retention. The document outlines the therapeutic uses of ACE inhibitors for conditions like heart failure and kidney disease, and discusses potential adverse effects like cough, hypotension, and hyperkalemia. It concludes by listing contraindications like previous angioedema or hypersensitivity to ACE inhibitors.
Crestor (Rosuvastatin Calcium Tablets)
Crestor (Rosuvastatin Calcium Tablets) is used together with exercise, diet, and weight-loss to treat high cholesterol, lower triglycerides and related conditions. It is also indicated for risk reduction of MI, stroke, heart attack and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors.
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This document discusses antihyperlipidemic agents, which are drugs used to lower lipid levels in the blood. It focuses on statins, describing their mechanism of action as inhibiting HMG-CoA reductase to reduce cholesterol synthesis and increase LDL receptors. This decreases LDL and IDL and increases HDL levels. The document also classifies primary and secondary hyperlipidemias, describes other antihyperlipidemic drugs like ezetimibe, fibrates, and niacin, and recommends lifestyle changes and drug therapy to manage hyperlipidemia.
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The document discusses the pharmaceutical sector in Bangladesh. It provides background on the history and growth of the pharmaceutical industry in Bangladesh. Key points include:
- The pharmaceutical sector has grown significantly since the 1980s and is now a major contributor to Bangladesh's economy. It supplies 97% of domestic medicine needs.
- The industry is highly regulated by bodies like the Directorate General of Drug Administration. The National Drug Policy of 1982 helped foster growth by promoting local production and restricting imports.
- Major local companies include Square Pharmaceuticals, Incepta Pharma, Beximco Pharma, and ACME Laboratories. The industry also includes some multinational companies.
- In 2012, Square Pharma
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Hyperlipidemia is a common disorder caused by abnormalities in lipid metabolism or transport. It results in high levels of lipids like cholesterol and triglycerides in the blood. Hyperlipidemia is classified based on the abnormal lipid levels and is primarily treated through lifestyle changes and medications that lower lipid levels. Common drug classes used to treat hyperlipidemia work by inhibiting cholesterol synthesis, breaking down fats, or blocking lipid absorption.
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Losartan simple presentation
Losartan is an angiotensin II receptor blocker used to treat hypertension. It works by competitively inhibiting the binding of angiotensin II to AT1 receptors, preventing vasoconstriction and lowering blood pressure. Common side effects include dizziness, hypotension, and hyperkalemia. Losartan has drug interactions with NSAIDs, potassium supplements, and lithium that can increase the risk of hyperkalemia and lithium toxicity. It is classified as pregnancy category D and contraindicated in pregnant women.
Unipril (Ramipril) ppt
Unipril is an antihypertensive medication containing ramipril that is presented as a treatment for hypertension, congestive heart failure, reducing cardiovascular risk, and proteinuric nephropathy. It works by inhibiting the angiotensin converting enzyme, thereby reducing blood pressure. Studies show Unipril reduces cardiovascular events in high-risk patients, provides the highest survival rate among ACE inhibitors for heart attack patients, and offers beneficial effects for diabetic patients by reducing cardiovascular death and events. It also effectively improves parameters in chronic nephropathy and eliminates the need for dialysis with long-term use.
Telmisartan
Telmisartan is an angiotensin receptor blocker (ARB) that is described as the "master sartan" due to several unique properties. It has a high trough-to-peak ratio, ensuring round-the-clock blood pressure control. It also has protective effects on target organs by reducing early morning blood pressure spikes. Additionally, telmisartan has beneficial effects beyond blood pressure lowering, such as reducing endothelial dysfunction through partial PPAR-gamma activation. These factors make telmisartan effective at preventing cardiovascular events like heart attacks and strokes.
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This document presents an overview of antihypertensive drugs. It discusses various classes of antihypertensive medications including ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, diuretics, sympatholytics, ganglionic blockers, adrenergic neuronal blockers, and vasodilators. For each class, it describes the mechanism of action, pharmacokinetics, adverse drug reactions, and clinical uses. It also discusses special considerations for use of antihypertensive drugs during pregnancy.
Statins
This document summarizes information about statins, including their uses, mechanisms of action, types, interactions, and safety considerations. It discusses how statins are used to prevent heart disease by lowering LDL cholesterol and discusses their four proposed mechanisms of action, including improving endothelial function and maintaining plaque stability. It also provides comparisons of different statin medications and identifies atorvastatin and simvastatin as producing the greatest LDL reduction, as well as pravastatin and fluvastatin as having fewer drug interactions.
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The document discusses expectations for the upcoming Indian budget. It provides context on the current strong economic growth outlook in India and top expectations. The key expectations are:
1) Focus on infrastructure development and asset monetization to fund infrastructure investments.
2) Stimulate MSMEs to create jobs and boost demand by addressing their challenges and improving access to credit.
3) Support disproportionately impacted sectors like travel and hospitality with revival plans and contingency measures for uncertainties.
Care budeget 2022 23 expectations
The document provides expectations from various industries for the upcoming 2022-23 Union Budget of India. It summarizes the results of a survey of 330 industry experts and analysts conducted by CareEdge to forecast what measures the Finance Minister could announce. Key expectations included higher spending on infrastructure, employment generation, healthcare, agriculture, and logistics infrastructure. Industries are expecting support through new welfare programs, tax concessions, higher allocations to existing schemes, and measures to boost sectors like manufacturing, exports, and disinvestment.
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Diuretics are recommended as first-line therapy for hypertension. The document discusses various classes of diuretics including loop diuretics, thiazides, thiazide-like agents, and potassium sparing agents. It provides examples of drugs in each class, their mechanisms of action, and sites of action. The document summarizes evidence from clinical trials showing that thiazide diuretics like chlorthalidone are more effective than hydrochlorothiazide at reducing cardiovascular events in hypertension. Indapamide is discussed as an alternative to hydrochlorothiazide with similar efficacy and fewer metabolic side effects. Combinations of ACE inhibitors or calcium channel blockers with diuretics are also effective antihy
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This document provides an overview of antihypertensive agents (blood pressure medications). It discusses the types and classes of antihypertensives, including diuretics, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, beta blockers, and alpha blockers. It describes the mechanisms of action, therapeutic uses, and potential side effects of each class. The document is intended to teach healthcare providers about selecting and utilizing different antihypertensive drugs to treat hypertension.
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Atorvastatin is a statin drug used to lower cholesterol and prevent cardiovascular events. It works by inhibiting HMG-CoA reductase in the liver to decrease cholesterol production. It is well absorbed orally but has low bioavailability. The liver metabolizes atorvastatin through CYP3A4 enzymes and excretes it primarily in bile. Grapefruit juice and certain other drugs can interact with atorvastatin metabolism. Its medical uses include treating various dyslipidemias and preventing heart attacks and strokes in those with risk factors like diabetes. Side effects may include muscle pain or weakness.
Antihyperlipidemic Agent
This document discusses various types of drugs used to treat hyperlipidemia. It begins by defining hyperlipidemia as a common disorder involving abnormal lipid metabolism that is a major cause of heart disease. It then describes several classes of antihyperlipidemic drugs, including HMG-CoA reductase inhibitors (statins), fibric acid derivatives, bile acid sequestrants, LDL oxidation inhibitors, and pyridine derivatives. For each class, examples of drugs are provided along with their mechanisms of action and effects on lipid levels.
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This document provides a business plan for Losartan Potassium (Losartan) in Bangladesh for 2015. It summarizes hypertension prevalence data from various sources, showing about 20% of people in Bangladesh have hypertension. The cardiovascular drug market is growing at 11% annually and Losartan has a 29.24% share of the antihypertensive market. The objectives for 2015 are to achieve 10% sales growth, a 4.9% market share, and reach the number 3 market position for Losartan. The strategies proposed include increasing prescriptions from specialty physicians like cardiologists and improving performance in metro areas through targeted promotional initiatives.
Losartan Tablet 50 mg - Summary of Product Characteristics
Losartan Tablet is used to treat patients with high blood pressure, chronic heart failure, to protect the kidney in hypertensive type 2 diabetes.
Marketing Plan
- The document provides information on a marketing plan for the launch of the drug Esoz 20, which contains 20 mg of esomeprazole.
- Key details include the target market of Rs. 102.23 crores growing at 23.14% annually, a sales forecast projecting sales of Rs. 2.5 crores in the first year, and a promotional budget of Rs. 30 lakhs.
- The marketing strategies outlined include focusing on gastroenterologists, physicians, surgeons and gynecologists in metro and class 1/2 cities, with a sales force of 400 MRs planned to make 96,000 calls per month.
ACE INHIBITORS.pptx
This document provides information about ACE inhibitors, which are a class of drugs used to treat hypertension. It begins by defining hypertension and describing antihypertensive drugs. It then focuses on ACE inhibitors, explaining their mechanism of action in blocking the conversion of angiotensin I to angiotensin II, thereby reducing vasoconstriction and sodium retention. The document outlines the therapeutic uses of ACE inhibitors for conditions like heart failure and kidney disease, and discusses potential adverse effects like cough, hypotension, and hyperkalemia. It concludes by listing contraindications like previous angioedema or hypersensitivity to ACE inhibitors.
Crestor (Rosuvastatin Calcium Tablets)
Crestor (Rosuvastatin Calcium Tablets) is used together with exercise, diet, and weight-loss to treat high cholesterol, lower triglycerides and related conditions. It is also indicated for risk reduction of MI, stroke, heart attack and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors.
7 antihyperlipidemic
This document discusses antihyperlipidemic agents, which are drugs used to lower lipid levels in the blood. It focuses on statins, describing their mechanism of action as inhibiting HMG-CoA reductase to reduce cholesterol synthesis and increase LDL receptors. This decreases LDL and IDL and increases HDL levels. The document also classifies primary and secondary hyperlipidemias, describes other antihyperlipidemic drugs like ezetimibe, fibrates, and niacin, and recommends lifestyle changes and drug therapy to manage hyperlipidemia.
Pharmaceutical industry in bangladesh(assigment)...n iloy
The document discusses the pharmaceutical sector in Bangladesh. It provides background on the history and growth of the pharmaceutical industry in Bangladesh. Key points include:
- The pharmaceutical sector has grown significantly since the 1980s and is now a major contributor to Bangladesh's economy. It supplies 97% of domestic medicine needs.
- The industry is highly regulated by bodies like the Directorate General of Drug Administration. The National Drug Policy of 1982 helped foster growth by promoting local production and restricting imports.
- Major local companies include Square Pharmaceuticals, Incepta Pharma, Beximco Pharma, and ACME Laboratories. The industry also includes some multinational companies.
- In 2012, Square Pharma
Antihyperlipidemic drugs
Hyperlipidemia is a common disorder caused by abnormalities in lipid metabolism or transport. It results in high levels of lipids like cholesterol and triglycerides in the blood. Hyperlipidemia is classified based on the abnormal lipid levels and is primarily treated through lifestyle changes and medications that lower lipid levels. Common drug classes used to treat hyperlipidemia work by inhibiting cholesterol synthesis, breaking down fats, or blocking lipid absorption.
Pharmacology of Hypolipidaemics drugs
Hypolipidaemics pharmacology with a note on Statins /Fibrates/ Sterol absorption Inhibitors/ CETP Inhibitors / Lipoprotein Lipase activators and Bile acid sequestrants
Community pharmacy
Community pharmacy is a place where medicines are stored, dispensed, and various healthcare services are offered by qualified pharmacists. The roles of a community pharmacist include processing prescriptions, providing patient counseling, treating minor ailments, promoting health, and maintaining pharmacy records. A community pharmacy must be properly established and managed in accordance with legal requirements regarding licensing, staff qualifications, and drug stocking. Community pharmacists have an ethical code to provide quality services, handle prescriptions carefully, maintain fair business practices, and uphold the dignity of the profession.
Losartan simple presentation
Losartan is an angiotensin II receptor blocker used to treat hypertension. It works by competitively inhibiting the binding of angiotensin II to AT1 receptors, preventing vasoconstriction and lowering blood pressure. Common side effects include dizziness, hypotension, and hyperkalemia. Losartan has drug interactions with NSAIDs, potassium supplements, and lithium that can increase the risk of hyperkalemia and lithium toxicity. It is classified as pregnancy category D and contraindicated in pregnant women.
Unipril (Ramipril) ppt
Unipril is an antihypertensive medication containing ramipril that is presented as a treatment for hypertension, congestive heart failure, reducing cardiovascular risk, and proteinuric nephropathy. It works by inhibiting the angiotensin converting enzyme, thereby reducing blood pressure. Studies show Unipril reduces cardiovascular events in high-risk patients, provides the highest survival rate among ACE inhibitors for heart attack patients, and offers beneficial effects for diabetic patients by reducing cardiovascular death and events. It also effectively improves parameters in chronic nephropathy and eliminates the need for dialysis with long-term use.
Telmisartan
Telmisartan is an angiotensin receptor blocker (ARB) that is described as the "master sartan" due to several unique properties. It has a high trough-to-peak ratio, ensuring round-the-clock blood pressure control. It also has protective effects on target organs by reducing early morning blood pressure spikes. Additionally, telmisartan has beneficial effects beyond blood pressure lowering, such as reducing endothelial dysfunction through partial PPAR-gamma activation. These factors make telmisartan effective at preventing cardiovascular events like heart attacks and strokes.
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Statins
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Sodium Alginate
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Losartan
- 1. Losartan Presentation by Primary Information Services www.primaryinfo.com mailto:primaryinfo@gmail.com
- 2. What is losartan? Losartan (Cozaar) belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losartan is used to treat high blood pressure (hypertension).
- 5. Hubei Aoks Bio-Tech Co., Ltd.
- 9. Market Scenario โข Global losartan market was valued at USD4.73 billion in 2020 and is expected to grow at a formidable rate of 7.81% โข The global losartan market is driven by the growing prevalence of hypertension, stroke and diabetic nephropathy across the world. Losartan is a medication that is used to treat high blood pressure โข Major players operating in the global losartan market include Merck & Co. Inc., Pfizer Inc., Teva Pharmaceutical Industries Ltd., Sanofi S.A., Novartis International AG, Dr. Reddyโs Laboratories Ltd., Sun Pharmaceuticals Industries Ltd., Aurobindo Pharma Ltd., Torrent Pharmaceutical Ltd., Lupin Ltd., Mylan N.V., Ipca Laboratories Limited, Macleods Pharmaceuticals Limited, Abbott Laboratories, Cadila Healthcare Limited, and others.
- 11. Database Offer - Contents Manufacturing Process Routes of Synthesis Batch Input and output and mass Balance of Losartan Base Process flow Diagram Pollution load of Losartan Base. Solvent Balance of Losartan Base Key Raw materials Environment Impact report, Consultant Patents, msds, COA, SDS Major Manufacturers