The document provides coaching notes on running an outside zone blocking scheme. It discusses various blocking techniques including base reaching, zone blocking, and cut blocks. It emphasizes reading defenders and blocking the inside-out to create running lanes for the running back to the outside. Various blocking combinations are described for different defensive alignments, including dealing with shaded looks and blitzes.
University of Nevada head coach Chris Ault developed the Pistol offense in 2004 as a way to add a power running game to the spread formation. The Pistol Offense, which is a cross between under center formations and the shotgun formation, lines the quarterback up three to four yards behind the center (rather than seven yards, as with the shotgun formation). In this formation, the quarterback is close enough to the line of scrimmage to be able to read the defense and far enough back to give him extra time and a better vision of the field just like in the shotgun.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Lobotzke Oz Clinic
1. Wake Forest Outside Zone Steed Lobotzke Greater Cleveland Coaches Clinic 2007 Notes of Keith Grabowski
2. Read the E and N. If E reached keep it outside. If E out, read nose, skinny of end; if N skates lateral,skinny off N. Aim Point is outside foot of the OT. Read is the DE. 18” splits. Helmet on belt of C. N E E A B 2 2
3. Base reach-try to reach the end, but don’t reach him. We just want that guy to widen. Threaten the base reach and he’ll widen N E E A B 2 2 BASE REACH
4. TE take a lateral step that opens the toe about 45 degrees.
5. Threaten reach with his far hand and hat. Showing reach flash it across the stripe on the guys hat. BASE REACH
6. Drag his backside hand and his backside foot to make sure that he doesn’t get beat inside. Grab the inside half and throw it out. BASE REACH
7. Here’s where all the work is at right here. When we get this uncovered look with this shade we talk about covered and uncovered. This is a zone block for us. We are trying to win on the 5 technique. We are hoping he’s tight enough where we can go lateral. N E E A B 2 2 BASE REACH
8. We talk about defenders as blocks and blocking the inside half of the block and the outside half of the block. The tackle(covered is working the outside half of the block), he’s going to Lateral step and the important step is his second step-he has to bring it to the midline of the body. And bring that backhand. Get the front hand on the front side shoulder cradle. Get 4 Hand on DL and stop looking at him. 4 Eyes to LB Get vertical push.
9. Lateral step and shoot head across like the TE. The difference is that I don’t have to Drag my backside hand because I have help. Bring my back hand and foot to the Midline of the body. Try to square up. Try to get him to push vertical. Base Reach 1 2
10. What I don’t want to do is I don’t want this guy to widen anymore if I can get out on him. So the running back will take the ball outside. Base Reach 1 2
11. Base Reach If the RB goes over the top, the LB is probably going to mirror him. So the OT is going to need to push thru and climb to the LB. G has to push thru vertical on DL. OT can push LB past if he needs to.
12. Base Reach If LB comes off inside we’re in pretty good shape. The G can fall off and be outside and the OT can keep his outside in position
13. If the 5 fights out hard show it to RB and G-take inside arm and throw him to the sideline. RB cut inside tech and G climb right now. Base Reach
14. Base Reach Last picture is an angling 5-G keep it and T constrict the space, step and try to keep that space small in that b gap that he’s trying to get thru. As you squeeze back on that guy it will bring you up to that LB. If LB gets over the top you can still kick him out. G show RB that he angled-wheel on him and really turn on him and show the RB that he has the outside half.
15. When we go back here, with the shade and BS3, see it as a zone block. C slight bucket and shoot your bs hand across to midline of shade. G will wheel on an angle-don’t go 4 hands on LB because he is quick over top. Keep C on N and work G thru heels and intercept the BSLB-play fast on the backside. BSLB rarely fits A gap-he will be quick overtop-trail technique and push LB thru when he breaks down to make the play. If 3 were to cross his face, BST would have to be fast to LB. N E E A B 2 2 BASE REACH ZONE BLOCK ZONE BLOCK- Fast Play
16. BS cuts 3 tech. If you put 4 hands on nose LB would be thru and N would be in an advantageuous position everytime. PLAY FAST ON THE BACKSIDE. As soon as he’s not coimng at you go skinny off his heels to the BSLB. Try to run to a spot and wait for him. IF the BSLB gets over the top of you, turn, chase him down and try to stay on a plane that’s slightly shallower than him. And when the ball cuts and he tries to break down and make that play, just push him through the play and the ball can cut off you. Call it a trail tech. just trail that BSLB as he runs into the play and then just push him thru when he tries to breakdown. N E E A B 2 2 BASE REACH ZONE BLOCK
17. Now the 3 could cross his face right there. If the guard is working fast, the 3 should not cross his face. But if he does get across his face, that tackle needs to go skinny off the heels of the 3 and replace the G and get the LB. It’s a long way to go, he really has to move. N E E A B 2 2 BASE REACH ZONE BLOCK ZONE BLOCK- Fast Play
18. Backside-coach cut blocks. Coach 2 cut blocks: a penetrator-lateral step, crossover and throw your shoulder into the guys lap, his own momentum will cut him. A lateral flow guy that won’t cross the LOS-flows when he sees that G go, it will be 4 or 6 steps and you may have to settle for getting your right shoulder on him and head behind and try to trip him up. Key is to tie him up, trip up and get him on the ground. N E E A B 2 2 BASE REACH ZONE BLOCK ZONE BLOCK- Fast Play CUT BLOCKS
19. RB read-if the E flows out, the RB is skinny off him. Skinny-as the end fights out here, hug that pile and try to get right back out where you were headed, stay away from the N. Or if N comes all the way out, go skinny off him. N E E A B 2 2 BASE REACH ZONE BLOCK ZONE BLOCK- Fast Play CUT BLOCKS
20. Same picture, but 2i. Get a lot of shade jumping to 2i. Now don’t use a true zone block. Base reach on the 5 tech, G rip left arm thru 2i, don’t want fs penetration hurting the play. C buckets and get the near half, G rip thru outside half. Still reading 5 tech, if 5 slants in G & T need to treat it like a twist pick up.(usually a kickout on the LB). N E E A B 2 2 BASE REACH ZONE BLOCK- Fast Play CUT BLOCKS BASE REACH rip
21. 4-3 look: RB still heading for outside leg of the OT. T E N A B E B
22. Covered guy with 9 tech, uncovered guy. We’re coaching 4 hands on 9 reading off to LB. If he comes over the top, TE comes off. If OT reaches E, RB has to bounce a little. More often than not the 9 fights out, RB stays skinny off the pile and OT climbs to LB. If he angles in we wheel on him and keep it out there also. T E N A B E B Zone Block E
23. With a backside 2i, we have a true zone block right here. Get 4 hands on the 3 tech, C buckets, see the MLB. Read off of him, if he’s over the top, the G is off, if he fills inside, the C picks him up. T E N A B E B Zone Block E Zone Block
24. The backside 2i is treated like the shade in the previous illustration, We will fast play it. Get a lot of flow out of WLB. So if 2i is coming at OT, he will step and wheel. But if he works up the field or flows at all, I go skinny off his heels and try to intercept WLB. If he gets over top of me, I am going to trail him and try to push him thru. G goes lateral and tries to get and keep the win on the 2i. T E N A B E B Zone Block E Zone Block N Fast Play Cut
25. T N A B E B E N Last picture has backside shade and a frontside 7 tech. Same RB read. Treat this zone block as broken: the E has already angled(by alignment).
26. T N A B E B T/TE = Base Reach E Zone Block N Fast Play Cut OLB will be hard t reach, so keep him out there. T has base reach on the E and tries to widen him. We try to push those two out of there on this configuration.
27. OLB will be hard t reach, so keep him out there. T has base reach on the E and tries to widen him. We try to push those two out of there on this configuration. T E N A B E B Zone Block E Zone Block N Fast Play Cut
28. Odd Front: 3-5; gap control defense. Treat the OLB as a 9 tech; zone block on the E and stacked LB; treat the N like the shade-flows with C, G is skinny off heels to LB. Slants away, G picks him up and C is off to LB. OT try to intercept the BSLB, TE cut the E. E A B E B Zone Block N Fast Play Cut $ $ Base Reach
29. Base reach on OLB, 2 zone blocks, bonus blocker in BST,BSTE cut E. Two 5 techs, two 9 techs. E A E B Zone Block N Cut 2 2 Base Reach Zone Block
30. Use another back or WR motioning in to handle the Safety coming down into the box. Two 5 techs, two 9 techs. E A E B Zone Block N Cut 2 2 Base Reach Zone Block $
Editor's Notes
G needs to bring back hand and boot foot to the near shoulder cradle and front hand To the midline of the body. We want to get four hands on that guy and push him vertical. Get 4 hands on him and then stop looking at him. When you get 4 hands on him, he’s not going anywhere. Just start pushing hard vertical and keep your eyes on the LB.
5tech fighting-could get hand to midline of body-so just throw him to the sideline at that point.
5tech fighting-could get hand to midline of body-so just throw him to the sideline at that point.
5tech fighting-could get hand to midline of body-so just throw him to the sideline at that point.
BS cuts 3 tech. If you put 4 hands on nose LB would be thru and N would be in an advantageous position every time. PLAY FAST ON THE BACKSIDE. As soon as he’s not coming at you go skinny off his heels to the BSLB. Try to run to a spot and wait for him. IF the BSLB gets over the top of you, turn, chase him down and try to stay on a plane that’s slightly shallower than him. And when the ball cuts and he tries to break down and make that play, just push him through the play and the ball can cut off you. Call it a trail tech. just trail that BSLB as he runs into the play and then just push him thru when he tries to breakdown.
Running reads are E, if he widens go skinny off him, if 3 widens we can go skinny off him. Our 3 choices are really within a few feet of each other, the 3 will really widen before we cut off of him. BSTE cuts.
Still try to true zone block on the 3 tech and MLB. 4 hands on the 3 tech, and read off of that LB. Go for cut block on the BS shade by the G. Lateral step and shoot the left shoulder across the lap. If he’s a fast flow, I’ll take 4 or 6 steps and probably right shoulder block with the head out the back.
BSOT go off the heels of the 3 and intercept BSLB. If 5 slants hard(we don’t want this, OT should be out, and TE will have to intercept LB.
Need to coach against a multitude of blitzes. LB’s running thru A-gap(3 guys in the 2 A gaps.); G constrict the A gap, left C get reach on LB and pick up the M flowing overtop. Treat it like twist pick-up. BST needs to hump it and get in there and we can’t let two guys in that gap.
Slant to the playside, BST picks up angling E, still have a hat for BSLB with C-G combo, and TE is bonus on BSLB.