Nutraceuticals: An Alternative to Treatment for Disease Prevention

Healing vs. Treatment
Manas Ranjan.
SunDyota Numandis -ProBios, India
‘Let Nutra be Your Medicine’
“THE DOCTOR OF THE FUTURE WILL GIVE NO MEDICATION, BUT WILL INTEREST HIS PATIENTS INTHE CARE OF THE
HUMAN FRAME, DIET AND IN THE CAUSE AND PREVENTION OF DISEASE.”
THOMAS EDISON
Nutra ‘the intelligent food’ could block the underlying causes of conditions such as Mental Stress,
Obesity, Cardiovascular Disease, Diabetes and various Neoplastic Diseases by linking Diet to health.
Looking in to the current Industry scenario for Indian Pharma, which has been grappling with various
regulatory challenges bursting with Amendments and Disciplinary Course Corrections, Distinguished
Pundits from pharma fraternity suggest the only way out could be, focusing more on Diagnostics &
Preventive therapies which includes ascertaining the Stage Wise Disease Evolution & Strategizing
Stage Centric customised Therapy,
Of course for the western world Preventive therapy is not a new concept, which is quite evident
from the volume of business of Nutraceuticals in the overseas markets.
People says majority of Europeans and significant number of Americans trust and consume
Nutraceuticals in daily basis, either recommended by physicians or guided by glittery advertisements
in health magazines or TV commercials
Going by a very common age-old belief “An Apple a Day Keeps the Doctor Away” the concept of
Nutra is a very ancient disease management theory, may be the present generation trying to
rediscover the very essence of the natural remedies
Going by some of the text book definitions, Nutraceuticals are Dietary supplementation, Functional,
Multi-functional Foods,
Coined from “Nutrition” & “Pharmaceutical” in 1989 by Stephen DeFelice,MD, Founder and
Chairman of the Foundation for Innovation in Medicine (FIM).
A Nutra can be a Nutrients (Substances which have established Nutritional functions e.g. Vitamins,
Minerals, Amino Acids, Fatty acids, etc.) , can be a Herbals/ Phytochemical (Herbs or Botanical
products), Dietary Supplements (Probiotics, Prebiotics, Antioxidents, Enzymes, etc.)
Classification of Nutraceuticals:
1. Functional foods: Any modified food or ingredients that may provide a benefit beyond the
traditional nutrients it contains (Such as vitamin-enriched products, ω-3 FA(DHA, EPA)
2. Nutritional supplements: (Such as Chondroitin & Glucosamine etc.)
3. Sport Drinks: (Such as Polysaccharides, Protein enriched drinks, Oral Hyaluronic Acid Drinks etc.)

4. Medically Formulated Foods: (Such as Boswellia Serrata, Rosehip and Curcumin etc.)
How Nutraceuticals are distinguished from Synthetic Drugs:
Synthetic Drugs Nutraceuticals
Lock and Key mechanism ( Blocks the Specific
receptors)
Mostly Enzymatic, Immune Stimulator,
Supplements the body’s deficiency
Synthetic Chemicals mostly derived from
Petroleum sources
Bioactive phytochemicals Chemicals, Natural
products from Natural sources (plant, animal,
Algae etc.), no chemical treatment
Treatment, Cause of Disease, temporary relief Healing, Root cause
Supresses the body Defence and act directly Work with ( Complements) body defence to
fight against the disease
Supresses or Disturbs the Body chemistry Nourishes or revitalise the Body chemistry
Often Cytotoxic It Detox the body from harmful toxin
For Acute Symptomatic Relief For Chronic Treatment/ Healing
Cure for the moment Preventive
Regulatory
1. Drug = article intended to diagnose,
cure, mitigate, treat, or prevent disease
2. Both intended to affect structure and
function of body
3. Drug must undergo FDA approval after
clinical studies to determine effectiveness and
safety
4. No pre-market testing
# Innovator responsible for safety evaluation
1. Not intended to diagnose, cure,
mitigate, treat, or prevent disease
 Foods not intended to affect structure
and function
 Intended only to supplement diet
 Not represented for use as
conventional food
2. Not intended as sole item of a meal or
the diet
3. No premarket approval
# Manufacturer responsible for safety
evaluation
Though earlier Nutraceuticals was expected to play a central role in preventative healthcare. With a
simple logic as you grow Old you are likely to invite lifestyle-related diseases, whose effect can be
reduced by making healthier choices prior in life. This leads to a sharper focus on measures, such as
a Health-promoting food, to prevent people from ever getting ill. Even many Physicians are also
using a lots of Nutra in the management of syndromes especially of chronic ailments,
The global market for functional foods certainly presents a big opportunity, sales are predicted to
reach US$350 billion by 2019, this is sizeable when compared with the $900 billion synthetic drug
market, but it is insignificant in relation to the $5 trillion worldwide food industry.
Tough the acceptance of Nutraceuticals is growing in India but a few immediate improvements can
bring impetus to this industry
Acceptance & Inclusion on Nutra in US
 1994 President Clinton signed Dietary Supplement, Health and Education Act (DSHEA) into
law
 Defined D/S as “separate regulatory category of food”
 Created Office of Dietary Supplements within National Institute of Health (NIH)
 Permits statements of nutritional support including structure and function claims

 After passage of DSHEA, sales increased to 13 billion per year.
 If D/S contains a new ingredient:
 Manufacturer must submit information that ingredient “can reasonably be
expected to be safe” within 75 days of marketing
 Safe = no significant risk of illness
DSHEA authorized to provide accurate information to consumers
Nutra product Label must include:
 Name of each ingredient
 Quantity of each ingredient
 Total weight of all ingredient if a blend
 Identity of part of plant derived from
 Term “Dietary Supplement”
 Must contain nutritional labeling information also
 Calories, fat, sodium
Key nutraceutical product hot spots
SunDyota Numandis – Pro Bios, India,
One Stop B2B Solution for Nutraceutical
BRAIN HEALTH AND AGING
Background: Based on WHO reports by 2020 over 65 million people will have dementia and that the
prevalence of other neurodegenerative brain diseases, like Alzheimer’s, is also in rise. The pressure
to device a successful treatment option is rising but has proved ineffective so far. Scientists are
gradually looking to food products to help slow disease progression and treat symptoms.
There are a range of products already in use are Citicoline, Ginkgobiloba and many new products in
pipeline that attempt to improve cognitive function. Enhancing brain glucose metabolism to delay

cognitive decline has been the target of some products, like Accera. There is also an increasing
number of products which claim to enhance normal brain function, such as Neurozan.
Stress Management
 LACTIUM: a natural product derived from Cow Milk
World’s most documented product for Stress Management
Available in 110 countries including US European Countries, Invented by Ingredia, France, a world
leader in dietary Nutritional ingredients and supplements, specializing in stress management.
 In India Marketed by: SunDyota Numandis – Pro Bios, India
GASTROINTESTINAL HEALTH
It is projected that over 100 million people globally are suffering from gut health problems and the
prevalence is rising. Home remedies (like Yakult) help to provide some symptom relief. They have a
positive effect on the millions of organisms that live in the human intestine (known as gut flora).
Many consumers purchase some form of ‘probiotic’ product and the market is increasing.
Probiotics
 Sources: Sour milk, yoghurt, Yeast (Saccharomyces spp.)
 Promote the growth of “friendly” bacteria, which help, fight diseases.
 Enhance the immune function.
 Probiotics given to women around the time of childbirth could protect children from atopic
eczema & AR.
 Various forms of diarrhoea in children.
 Antibiotics associated Diarrhoea
 Ease symptoms of lactose intolerance.
MICROBAC GG®
Most Researched Probiotic with over 1000 Clinical Publications. Superior Stability & efficacy by its
Microbact Technology, Available in US, Italy & European Countries etc.
Invented by Probiotical, Italy, a world leader in research and innovation of technologically advanced,
strain specific probiotics and pharma-biotics for various conditions.
S.boulardii:
World’s only Fluidized S.boulardii with 80% survivability, also available in European Countries & US
Invented by Lesaffre, France, The world’s largest yeast manufacturing company with a legacy of over
160 years.
BSCU1
Bacillus Subtilis

The Only probiotic in the world which can act on both on Absorption and Secretory Channels
US & European Countries etc., Invented by Lesaffre, France, the world’s largest yeast manufacturing
company with a legacy of over 160 years.
Respiratory Probiotics
AAP2
India’s 1st
heat-killed and synergistic composition of 2 bacterial strains for Root cause management
Of Allergic Rhinitis & Atopic Asthma Cases, Root cause therapy for Atopic Dermatitis by managing
Th1 and Th2 Balance
Available in Asia, US & European countries
Invented by GenMont, Taiwan, A renowned name in research and development of technologically
advanced probiotics, given innovative products to many fortune 500 companies including Merck
Male Infertility
TRADAFERTIL
Invented by TradaPharma, Switzerland, Specializes in a wide range of products for men’s Sexual
Health
Synergistic Natural Herbal composition which works beyond antioxidants and backed up by 5 clinical
trials
Products having strong presence in Switzerland, Middle East
Erectile Dysfunction
Tradamix:
Invented by TradaPharma, Switzerland, Specializes in a wide range of products for men’s sexual
health, Synergistic composition of 3 different herbs for correcting the root cause of Erectile
Dysfunction
Switzerland & Middle East Countries
BPH & LUTS
Invented by TradaPharma, Switzerland, Specializes in a wide range of products for men’s sexual
health, Synergistic composition of 4 different herbs for managing BPH & LUTS
Specializes in a wide range of products for men’s sexual health.
DENTAL HEALTH

Dental Probiotics: ADP-1
Probiotics ADP2 are helping dentist to treat gingivitis & Dental carries
Heat Killed Probiotic having a significant impact on Dental Caries, Gingivitis and other dental
problems by acting on S.mutans & P. gingivalis
CARDIO & HEART HEALTH
The effect of cardiovascular disease (CVD) is substantial. It is the number one cause of death
globally. The risk of contracting CVD is associated with lifestyle choices including a poor diet. There
are three main opportunities for nutraceuticals in heart health.
1. Nutraceuticals that reduces cholesterol,
2. Nutraceuticals that reduces circulation of freeradicals (which contribute to plaque formation
in arteries)
3. Nutraceuticals that promotes Fibrinolytic activity (plaque break down).
Stress Management
LACTIUM
A natural product derived from Cow Milk,
World’s most documented product for Stress Management
Available in 110 countries including US European Countries
Invented by Ingredia, France, A world leader in dietary nutritional ingredients and supplements,
specializing in stress management.
ENDOCRINE HEALTH & DIABETES
Based on The WHO assessment, 347 million people worldwide have diabetes. Sustained exposure
to high blood glucose is linked to the consumption of high fat and high sugar content foods. Foods
which release sugars slowly enable better glucose control which can reduce the impact of diabetes
for sufferers, and can also help to prevent the onset of type 2 diabetes, Recently European Food
Standards Authority (EFSA) approved Benecarb; a low glycaemic index sugar substitute for diabetics.
There are also a number of studies looking at food products that re-sensitize the body to insulin.
The shift in healthcare from treatment to prevention is encouraging clinicians and patients to think
differently about health and disease, and creating momentum for nutraceuticals, with opportunities
for pharma and food companies to get involved in the disease/care pathway.
BONE & JOINT HEALTH
OA currently India’s no.1 disease ahead of HIV and Cancer
In the age group of 25-35, OA figures as the second most prevalent disease

Worth noting: 36% of OA patients are asymptomatic (of 20-40 age) with minor joint pain
Over 80% of the population will have radiographic evidence of OA by age 65
India may have 60 Million Osteoarthritis cases by 2025
The incidence of OA in India is as high as 12%
 Glucosamine (an amino-sugar) is a nutrient found in very small amounts in foods
 Necessary for the formation of cartilage, connective tissue and synovial fluid.
 Useful in osteoarthritis, joint/connective tissue injury
Glucosamine – chondroitin combination
 Chondroitin -Naturally occurring sub that inhibit the enzymes that degrade cartilage
 Draws fluid into cartilage thereby preventing it from premature degeneration
 B.serrata for effective pain management in OA patients
 Also acts as a building blocks for the creation of healthy new cartilage
OA Pain
Aflapin:
Selective 5 Lox Inhibitor, World’s only potentn selective 5-LOX Inhibitor. Alleviating the Joint pain as
soon as 5 days, Invented by LailaNutra, a leading name in research and development of
phyto -pharmaceuticals, with over 300 patented botanical extracts.
CurQLife:
Most bioavailable curcuminoid with unique HLB technology-COX 2 inhibition, Invented by LailaNutra
a leading name in research and development of phytopharmaceuticals, with over 300 patented
botanical extracts.
Rosehip:
Potent Anti-Inflammatory agent widely used for OA pain
Global leader in Specialty plant-based natural Ingredients, Invented by Natirex, USA
OA Cartilage Protection
Native Denatured Collagen-2
It has a unique mode of action by addressing the immune mediated cartilage destruction
Global leaders in research and development of unique molecules for Bone & Joint Health care
Mobility a growing Market

 43% of consumers aged 40 to 65 suffer from joint discomfort. 1
 It is estimated that 45% of people over 65 suffer from joint problems and 25% suffer from
sarcopenia, the loss of muscle mass due to age. 4
 4 out of every 5 menopausal women report joint discomfort, as a result of decreased
oestrogen production. 2
 Exercise is a risk factor for developing joint and muscle conditions. Studies have shown that
running 30km/week multiplies the probability of developing osteoarthritis by 2.4.3
Synovial Fluid Protection
Oral Hyaluronic Acid
Rooster Comb Extract, naturally rich in Hyaluronic Acid, Pre-digested form of Hyaluronic acid for the
endogenous generation of Synovial fluid and enhancing the muscle strength,
Invented by Bioiberica, Spain, Global leaders in research and development of unique molecules for
Bone & Joint Health care, Available in SPAIN, US, AUSTRALIA, UK, BELGIUM, SPAIN, TURKEY, CHILE,
POLAND.
Fracture Healing
ST 5:1
First time of its kind product, Most advanced formula for accelerated fracture healing
A leading name in research and development of Phytopharmaceuticals with over 300 patented
botanical extracts.
Invented by LailaNutra, a leading name in research and development of
Phyto -pharmaceuticals, with over 300 patented botanical extracts.
Tendonitis
Tendofit
Only evidence based formula for Tendon Health, Invented by Bioiberica, Spain a Global leaders in
research and development of unique molecules for Bone & Joint Health care
Tendinopathy is the most common soft tissue disorder and has become much more prevalent in
recent decades
An increasing number of patients wants a
• Quick Recovery
• Active Recovery
• Natural Recovery
Mucopolysaccharides:
Tendon Specific highly purified cartilage extract with high concentration of glycosaminoglycan
(Condroitin Sulphate with Hyaluronic Acid & other Mucopolysaccharides)
• Twenty Clinical Trials
• 14 million patients
• 10 years of Experience

Osteoporosis
ChoSA:
Advanced Endogenous collagen generator for Bone & Joint health, available in US, CANADA,
EUCADOR, GERMANY etc., invented by Bio-minerals, Belgium a globally prominent name in Derma-
Cosmetics
GYNAC HEALTH
Phytoestrogen
Reduce menopause symptoms,  bone health
Reduce cancer and heart diseases
Many Vitamins like Compounds used for Gynaecological practices are from Nutraceuticals sources,
L- Carnitine: Helps in oxidation of fatty acids, role in oxidative phosphorylation,
Choline: Lipotropic agent, used to treat fatty liver and disturbed fat metabolism,
Inositol: For amino acid transport and movement of Potassium and sodium,
Taurine: Helps in retinal photoreceptor activity, bile acid conjugation, WBC antioxidant activity, CNS
neuromodulation, platelet aggregation, cardiac contractibility, sperm motility, insulin activity
Teenage PCOS
Caronositol:
Most refined DCI for management of acne and Hirsutism
Invented by Biosearch Life, Spain
PCOS associated Infertility
Therapeutic dose of 300 mg DCI +1100 mg of MI in a tablet formulation
Invented by Biosearch Life, Spain
Treatment of perimenopause, menopause & post menopause
Err731:
Invented by Finzelberg, Germany
Natural solution for peri-menopause, menopause & post menopause with
11 clinical Publications, 21 years PMSS data,
Exclusive manufacturer of herbal extracts for dietary supplements available in US & European
Countries
Weight Management

Merastin:
India’s most studied product for Weight Management & Metabolic Control with a significant
impact on Hip-Waist Ratio
Laila Nutra, India, a leading name in research and development of Phyto-pharmaceuticals with
over 300 patented botanical extracts, Products are popular in US & European Countries
Most popular Gynac Minerals are also from nutra sources,
Calcium: essential for bone and teeth, maintaining bone strength, nerve, muscle and glandular
function, blood clotting,
Iron: energy production, Hb, oxygen transport,
Magnesium: for healthy nerve and muscle function, bone formation,
Phosphorous: energy production, phosphorylation process, bone and teeth, for genetic material,
Cobalt: component of Vit. B 12 and B 12 coenzymes,
Copper: Hb and collagen production, function of heart, energy production, absorption of Iron,
Iodine: proper function of Thyroid gland,
Chromium: with insulin it helps in conversion of carbohydrate and fat into energy, treatment of
diabetes,
Selenium: Antioxidant, functioning of heart muscle, part of GPX enzyme,
Zinc: Essential for cell reproduction, for development in Neonates, wound healing, production
of sperm and testosterone hormone,
SKIN & HAIR
Evening Primrose Oil,
Cosmetic purposes to improve skin, hair, and nails
Treatment atopic eczema and pre-menstrual syndrome
Popular with women as an aid in regulating the menstrual cycle.
Biosil:
Worlds only Endogenous Collagen generator for Skin hair and Nails
A globally prominent name in derma-cosmetics, US & European Countries
Natural Skin Moisturizer:
Oral Moisturizer for Skin hydration and nutrition by endogenous generation of Hyaluronic acid
Global leaders in research and development of unique molecules
Alovera
Treatment of radiation burns, wounds, skin ulcers.
Cosmetic skin preparation; eczema,

Arthritis, diabetes, HIV/AIDS?
Burns and skin irritations
Laxative
Caution: juice should not be taken in pregnancy.
There are also many well-known Nutraceutical,
Which we are using for our common vitality
Caroteinoids:
- Caroteine: Nutralises free radicals
Luteine: Healthy vision
Zeoxanthine: Healthy vision
Lycopene: Reduce prostate cancer
GINSENG
Used for centuries as a cure-all and tonic for the body.
Traditional Chinese medicine for maintaining physical and mental balance in human body.
Enhances antibody production
Increases interferon production
Reduces BP, myocardial necrosis & cholesterol
Prevents liver damage to ethanol
Hypoglycaemic & stimulates insulin release
GINKGO
Consists of dried leaves of Ginkgo biloba
Diminished memory and concentration, increased absent-mindness, confusion, energy loss,
tiredness, depression, dizziness and tinnitus, dementia including Alzheimer’s. Senility
“Cerebral insufficiency” which could lead to dementia
GINGER
Zingiber officinale rhizome.
Compared with conventional drugs as anti-nausea and travel sickness
Nausea from anesthetic effects after surgery
In hyper emesis gravidarum- a severe form of nausea and vomiting related to pregnancy
reduce the severity of nausea and the # of vomiting attacks in cases of early pregnancy-and safe
Gingerols and shagoals – Non volatiles
GARLIC
Anti-cholesterol and anti-thrombotic-inhibit platelet aggregation
Antibacterial, antifungal, antiviral, anti-tumor and anti-diabetic
Useful in patients with old or acute myocardial infarction.
B.P. ,arteriosclerosis
It helps regulate cholesterol levels and maintain heart health.
Milk Thistle

Prevent liver damage, regenerating cells and large areas of liver tissue damage.
Treat acute and chronic viral hepatitis B, fatty liver, cirrhosis and toxin-induced injury, radiation,
etc.
NEEM TREE
Antibacterial and antifungal properties- preparation –skin preparation including soaps
Toothpaste- protect teeth from decay and tooth rot and gum disorders
Antimalarial activity –Boiled leaves (gedunin and nimbolide)
Antidiabetic (nimbinin and nimbadiol)
PHYTOCHEMICALS:
Phytochemicals could provide health benefits as:
Substrate for biochemical reactions
Cofactors of enzymatic reactions
Inhibitors of enzymatic reactions
Absorbents that bind to & eliminate undesirable constituent in the intestine
Scavengers of reactive or toxic chemicals
Enhance the absorption and / or stability of essential nutrients
Selective growth factor for beneficial bacteria
Fermentation substrate for beneficial bacteria
Selective inhibitors of deleterious intestinal bacteria
Way forward
In a time when India’s normal life expectancy is on the rise, in near future we may see
many Pharmaceuticals giants to join hands with food production companies & Nutraceuticals
firms to launch Innovative Nutraceutical Supplements for treating many chronic ailments,
especially in a scenario when the drug research pipeline is dry and existing synthetic drugs are
confronting with regulatory & Pricing pressures
Nutraceutical & Pharmaceuticals companies could complement each other, through their
expertise,
 Nutraceuticals Companies: Experience of various phytochemicals, Extraction expertise,
Huge Distribution Strength
 Pharmaceuticals Companies: Experience of Disease Evolution, Patient Journey, Data
creation (Clinical Trial & PMS),Pharmacokinetic & Dynamic Studies, Scientific
Communication, CME & Advisory group meeting, Direct to Consumer knowledge, PLC &
Meeting regulatory requirements
There will be many Mergers & Strategic Alliances between Pharma and Nutraceuticals
companies as both will leverage each other’s core competencies
At the outset we don’t see Pharma & Nutra will ever contest each other, rather they with
complements each other as Drug will be for Immediate symptom relieve especially in Acute

symptoms (for 3 to 14 days) & Nutra for healing (3 months to lifelong) & ensuring complete
Cure with minimum side effects especially in Chronic progressive diseases
But for one stop B2B solution,
SunDyota Numandis – Pro Bios will play a pivotal role between the Global Innovators and Indian
Pharma companies. Ultimately IPM will see a spur in its top line
Role of Nutraceuticals in OA management
And many more …
Thank you …
I solicit your advice
manas_bhuyan2001@yahoo.com

Nutraceuticals: An Alternative to Treatment for Disease Prevention

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Nutraceuticals: An Alternative to Treatment for Disease Prevention