Ion channels are integral proteins
Plays a vital role in functioning of a cell
Genetic identification of ion channels has
improved our understanding……….
volume is ~10–12
at the rate of
After one sec
there will be
no k+ in cell
Hence to b effective in altering the
membrane potential …………….
The opening & closing of channel should be
brief and fast……….
Structural basis of
permeation & selectivity
4 sub units are clustered to form to
form ion permeation pathway..
About 78 human genes have been
K+ channels are tetramers composed of
four alpha subunits..
CLASSIFICATION OF K+ CHANNELS
2TM/P is essentially a universal feature of k+
it has amino tetramerization domain, carboxy
terminal, protein interacting domain..
standard nomenclature of these channels was
proposed by Nomenclature and Drug
Classification International Union of Basic and
Clinical Pharmacology Committee on Receptor
Nomenclature and Drug classification (NCIUPHAR)