Biochempeg continuously expands its capability to provide large-scale manufacture of high purity monodisperse PEG derivatives with an extensive variety of functional groups, in both non-GMP and GMP grade.
Watec Labs is a customer oriented R&D company specialized in complex, multi-stage customer synthesis, pilot-plant enlargement, process optimization and industrial production, especially expert in Advanced intermediates, Piperidine, Pyrimidine, Pyridine, Quinoline and Chiral derivatives.
Synova chemicals was established in 2008 with a vision to expand globally. For the last 10 years, they have served customers premium quality products and services, establishing themselves as a pioneer trading company and supplier of various chemicals. Their success comes from delivering optimal quality products at competitive prices with high responsiveness, integrity, and commitment to quality. They continuously supply cost-effective, good quality products to all customers.
Propylene Production by Propane Dehydrogenation (PDH)Amir Razmi
In this article a description about different processes which are commercialized to produce propylene via Propane dehydrogenation were presented.
To receive more reports about cost estimation analysis and other reports (about the propylene and PDH ) contact the author.
In fat analysis, precision is key. Our cutting-edge equipment employs advanced spectroscopic and chromatographic techniques, delivering accurate and reliable results. From gas chromatography to near-infrared spectroscopy, our arsenal ensures comprehensive fat analysis across various samples. With our state-of-the-art equipment, we provide invaluable insights for nutritional labeling, product development, and quality assurance, empowering you to make informed decisions with confidence.
Tigecycline Impurities Manufacturer and suppliers in India - Hemarsh Technologies was established in 2008 and since then our company has enjoyed a rapid growth. Our prime focus is on contract research and impurities synthesis for pharmaceutical industries.
Cyclic Peptides Current Status & Future Prospects.pdfDoriaFang
Cyclic peptides have potential advantages over linear peptides as drug candidates due to increased stability, binding affinity, and membrane permeability. Many cyclic peptides are approved drugs or in clinical trials. Recent trends include using modern technologies to discover novel cyclic peptides and developing peptide-drug conjugates to selectively deliver therapeutic payloads. Over 50 cyclic peptides have been approved, including pegcetacoplan which targets C3 complement proteins. Hundreds of cyclic peptides are in the research pipeline, and their prospects for drug development remain promising.
Antibody–Oligonucleotide Conjugates (AOCs) in Clinical Trials.pdfDoriaFang
Summary of Antibody–Oligonucleotide Conjugates(AOCs) in Clinical Trials, including products from Avidity Biosciences, Dyne Therapeutics, Tallac Therapeutics and Denali Therapeutics.
Watec Labs is a customer oriented R&D company specialized in complex, multi-stage customer synthesis, pilot-plant enlargement, process optimization and industrial production, especially expert in Advanced intermediates, Piperidine, Pyrimidine, Pyridine, Quinoline and Chiral derivatives.
Synova chemicals was established in 2008 with a vision to expand globally. For the last 10 years, they have served customers premium quality products and services, establishing themselves as a pioneer trading company and supplier of various chemicals. Their success comes from delivering optimal quality products at competitive prices with high responsiveness, integrity, and commitment to quality. They continuously supply cost-effective, good quality products to all customers.
Propylene Production by Propane Dehydrogenation (PDH)Amir Razmi
In this article a description about different processes which are commercialized to produce propylene via Propane dehydrogenation were presented.
To receive more reports about cost estimation analysis and other reports (about the propylene and PDH ) contact the author.
In fat analysis, precision is key. Our cutting-edge equipment employs advanced spectroscopic and chromatographic techniques, delivering accurate and reliable results. From gas chromatography to near-infrared spectroscopy, our arsenal ensures comprehensive fat analysis across various samples. With our state-of-the-art equipment, we provide invaluable insights for nutritional labeling, product development, and quality assurance, empowering you to make informed decisions with confidence.
Tigecycline Impurities Manufacturer and suppliers in India - Hemarsh Technologies was established in 2008 and since then our company has enjoyed a rapid growth. Our prime focus is on contract research and impurities synthesis for pharmaceutical industries.
Cyclic Peptides Current Status & Future Prospects.pdfDoriaFang
Cyclic peptides have potential advantages over linear peptides as drug candidates due to increased stability, binding affinity, and membrane permeability. Many cyclic peptides are approved drugs or in clinical trials. Recent trends include using modern technologies to discover novel cyclic peptides and developing peptide-drug conjugates to selectively deliver therapeutic payloads. Over 50 cyclic peptides have been approved, including pegcetacoplan which targets C3 complement proteins. Hundreds of cyclic peptides are in the research pipeline, and their prospects for drug development remain promising.
Antibody–Oligonucleotide Conjugates (AOCs) in Clinical Trials.pdfDoriaFang
Summary of Antibody–Oligonucleotide Conjugates(AOCs) in Clinical Trials, including products from Avidity Biosciences, Dyne Therapeutics, Tallac Therapeutics and Denali Therapeutics.
Alzheimer's Disease Drug Development Aducanumab, Lecanemab & Donanemab.pdfDoriaFang
Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive and behavioral impairment. Here we introduce the development of AD drugs (Aducanumab, Lecanemab & Donanemab).
ROR1 ADCs in Clinical Trials MK-2140, NBE-002 & CS5001.pdfDoriaFang
Three ROR1-targeted antibody-drug conjugates are in clinical trials: MK-2140, NBE-002, and CS5001. MK-2140, developed by Merck, links MMAE to an anti-ROR1 antibody and has shown an ORR of 30-80% in phase 1/2 trials. NBE-002, developed by Boehringer Ingelheim, uses site-specific conjugation of an anti-ROR1 antibody to a toxin and aims to convert cold tumors to hot tumors. CS5001, developed by CStone Pharmaceuticals, uses a novel linker and prodrug strategy to improve safety, and is in phase 1 trials. ROR1 is highly expressed
Summary of Targeted Protein Degradation in Clinical Trials.pdfDoriaFang
Summary of targeted protein degradation, such as PROTAC and molecular glues in clinical trials. PROTAC and molecular glues are the two main modes of TPD technology based on the UPS.
Cleavable Linkers Used In ADC Development.pdfDoriaFang
The linker used in ADC is divided into two types: cleavable linker and non-cleavable linker. This artile mainly introduced the cleavable linkers used in ADC development.
The Role of Four Lipid Components Of LNPs.pdfDoriaFang
The document summarizes the key components of lipid nanoparticles (LNPs), which are important for mRNA vaccine and nucleic acid therapy delivery. LNPs generally consist of four components - ionizable cationic lipids, phospholipids, cholesterol, and PEG lipids. Each component plays an important role in LNP stability, transfection efficacy, and safety. Ionizable cationic lipids determine LNP surface charge and toxicity. Phospholipids and cholesterol contribute to LNP formation and endosomal escape. PEG lipids influence particle size and stability but can also reduce efficacy and cause immune responses. The properties and roles of each component are described.
Trophoblast Glycoprotein (TPGB5T4) A New Target For ADC Drugs.pdfDoriaFang
The more popular targets in ADC drugs include HER2, TROP2, EGFR, CLDN18.2, c-Met, CD19, PSMA, Muc1, BCMA and PDL1. Here we will introduce a new ADC target trophoblast glycoprotein (TPBG).
Similar to HER2, Trop-2 is a new hot target for research. Trodelvy has been one of the products receiving much attention in recent years, and Dato-DXd from AstraZeneca/Daiichi Sankyo is also advancing rapidly.
DS-8201 (Enhertu) A Potential ADC Drug Targeting HER2.pdfDoriaFang
Enhertu (fam-Trastuzumab deruxtecan-nxki) is a HER2-targeting ADC drug jointly developed by AstraZeneca and Daiichi Sankyo, also known as DS-8201 or T-DXd.
List of New Anti-cancer Drugs Approved By FDA In The First Half of 2023.pdfDoriaFang
What are the new anti-cancer drugs approved in the first half of the year? The new drugs approved covered a variety of solid tumors and blood tumor types.
The Future Development of ADC For Cancer.pdfDoriaFang
Antibody-drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs to selectively deliver drugs to tumor sites. ADCs have shown promise in treating cancer but have faced challenges developing therapies for solid tumors. Future development of ADCs includes novel tumor targets, payloads with new mechanisms of action, improved linker techniques, and new antibody forms. While innovations still need validation, research has provided encouraging results, and ADCs are expected to have an increasingly important role in cancer treatment over the next decade.
Summary of ADC Targets For Solid Tumors & Hematological Tumors.pdfDoriaFang
Currently, popular targets include CD family, BCMA, HER2, TROP2, Tissue factor, Nectin-4, FRα, EGFR, etc. Here, we briefly introduce ADC targets in solid tumors and hematological tumors.
New Oncology Trends ADCs, Bispecific Antibodies & CAR-T Cell.pdfDoriaFang
Scientists are turning their attention to more innovative therapeutic strategies, such as next-generation ADCs, bispecific antibodies and CAR-T cell therapies, etc. as cancer therapy.
Summary of Treatments for Multiple Myeloma.pdfDoriaFang
Currently, there are a variety of drugs available for multiple myeloma, including traditional cytotoxic drugs, immunomodulatory analogs, proteasome inhibitors, antibody-based drugs and CAR T-cell therapy.
Bispecific Antibody-drug Conjugate Drugs In Clinical or Preclinical.pdfDoriaFang
The document summarizes several bispecific antibody-drug conjugates (ADCs) currently in clinical or preclinical development. It describes ZW-49 and M1231, which are HER2/HER2 and MUC1/EGFR bispecific ADCs, respectively. It also discusses JSKN003, a HER2 bispecific ADC, and BL-B01D1, an EGFR/HER3 bispecific ADC. The document notes that bispecific ADCs have potential advantages over monoclonal ADCs but development is challenging and few are currently beyond early stages of research.
PROTAC Delivery System Recent Research Advances.pdfDoriaFang
The combination of PROTAC and multifunctional delivery systems will open up new research directions in the field of TPD. Here we will introduce the combination of PROTAC and multifunctional delivery systems.
At Techbox Square, in Singapore, we're not just creative web designers and developers, we're the driving force behind your brand identity. Contact us today.
Structural Design Process: Step-by-Step Guide for BuildingsChandresh Chudasama
The structural design process is explained: Follow our step-by-step guide to understand building design intricacies and ensure structural integrity. Learn how to build wonderful buildings with the help of our detailed information. Learn how to create structures with durability and reliability and also gain insights on ways of managing structures.
Alzheimer's Disease Drug Development Aducanumab, Lecanemab & Donanemab.pdfDoriaFang
Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive and behavioral impairment. Here we introduce the development of AD drugs (Aducanumab, Lecanemab & Donanemab).
ROR1 ADCs in Clinical Trials MK-2140, NBE-002 & CS5001.pdfDoriaFang
Three ROR1-targeted antibody-drug conjugates are in clinical trials: MK-2140, NBE-002, and CS5001. MK-2140, developed by Merck, links MMAE to an anti-ROR1 antibody and has shown an ORR of 30-80% in phase 1/2 trials. NBE-002, developed by Boehringer Ingelheim, uses site-specific conjugation of an anti-ROR1 antibody to a toxin and aims to convert cold tumors to hot tumors. CS5001, developed by CStone Pharmaceuticals, uses a novel linker and prodrug strategy to improve safety, and is in phase 1 trials. ROR1 is highly expressed
Summary of Targeted Protein Degradation in Clinical Trials.pdfDoriaFang
Summary of targeted protein degradation, such as PROTAC and molecular glues in clinical trials. PROTAC and molecular glues are the two main modes of TPD technology based on the UPS.
Cleavable Linkers Used In ADC Development.pdfDoriaFang
The linker used in ADC is divided into two types: cleavable linker and non-cleavable linker. This artile mainly introduced the cleavable linkers used in ADC development.
The Role of Four Lipid Components Of LNPs.pdfDoriaFang
The document summarizes the key components of lipid nanoparticles (LNPs), which are important for mRNA vaccine and nucleic acid therapy delivery. LNPs generally consist of four components - ionizable cationic lipids, phospholipids, cholesterol, and PEG lipids. Each component plays an important role in LNP stability, transfection efficacy, and safety. Ionizable cationic lipids determine LNP surface charge and toxicity. Phospholipids and cholesterol contribute to LNP formation and endosomal escape. PEG lipids influence particle size and stability but can also reduce efficacy and cause immune responses. The properties and roles of each component are described.
Trophoblast Glycoprotein (TPGB5T4) A New Target For ADC Drugs.pdfDoriaFang
The more popular targets in ADC drugs include HER2, TROP2, EGFR, CLDN18.2, c-Met, CD19, PSMA, Muc1, BCMA and PDL1. Here we will introduce a new ADC target trophoblast glycoprotein (TPBG).
Similar to HER2, Trop-2 is a new hot target for research. Trodelvy has been one of the products receiving much attention in recent years, and Dato-DXd from AstraZeneca/Daiichi Sankyo is also advancing rapidly.
DS-8201 (Enhertu) A Potential ADC Drug Targeting HER2.pdfDoriaFang
Enhertu (fam-Trastuzumab deruxtecan-nxki) is a HER2-targeting ADC drug jointly developed by AstraZeneca and Daiichi Sankyo, also known as DS-8201 or T-DXd.
List of New Anti-cancer Drugs Approved By FDA In The First Half of 2023.pdfDoriaFang
What are the new anti-cancer drugs approved in the first half of the year? The new drugs approved covered a variety of solid tumors and blood tumor types.
The Future Development of ADC For Cancer.pdfDoriaFang
Antibody-drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs to selectively deliver drugs to tumor sites. ADCs have shown promise in treating cancer but have faced challenges developing therapies for solid tumors. Future development of ADCs includes novel tumor targets, payloads with new mechanisms of action, improved linker techniques, and new antibody forms. While innovations still need validation, research has provided encouraging results, and ADCs are expected to have an increasingly important role in cancer treatment over the next decade.
Summary of ADC Targets For Solid Tumors & Hematological Tumors.pdfDoriaFang
Currently, popular targets include CD family, BCMA, HER2, TROP2, Tissue factor, Nectin-4, FRα, EGFR, etc. Here, we briefly introduce ADC targets in solid tumors and hematological tumors.
New Oncology Trends ADCs, Bispecific Antibodies & CAR-T Cell.pdfDoriaFang
Scientists are turning their attention to more innovative therapeutic strategies, such as next-generation ADCs, bispecific antibodies and CAR-T cell therapies, etc. as cancer therapy.
Summary of Treatments for Multiple Myeloma.pdfDoriaFang
Currently, there are a variety of drugs available for multiple myeloma, including traditional cytotoxic drugs, immunomodulatory analogs, proteasome inhibitors, antibody-based drugs and CAR T-cell therapy.
Bispecific Antibody-drug Conjugate Drugs In Clinical or Preclinical.pdfDoriaFang
The document summarizes several bispecific antibody-drug conjugates (ADCs) currently in clinical or preclinical development. It describes ZW-49 and M1231, which are HER2/HER2 and MUC1/EGFR bispecific ADCs, respectively. It also discusses JSKN003, a HER2 bispecific ADC, and BL-B01D1, an EGFR/HER3 bispecific ADC. The document notes that bispecific ADCs have potential advantages over monoclonal ADCs but development is challenging and few are currently beyond early stages of research.
PROTAC Delivery System Recent Research Advances.pdfDoriaFang
The combination of PROTAC and multifunctional delivery systems will open up new research directions in the field of TPD. Here we will introduce the combination of PROTAC and multifunctional delivery systems.
At Techbox Square, in Singapore, we're not just creative web designers and developers, we're the driving force behind your brand identity. Contact us today.
Structural Design Process: Step-by-Step Guide for BuildingsChandresh Chudasama
The structural design process is explained: Follow our step-by-step guide to understand building design intricacies and ensure structural integrity. Learn how to build wonderful buildings with the help of our detailed information. Learn how to create structures with durability and reliability and also gain insights on ways of managing structures.
Company Valuation webinar series - Tuesday, 4 June 2024FelixPerez547899
This session provided an update as to the latest valuation data in the UK and then delved into a discussion on the upcoming election and the impacts on valuation. We finished, as always with a Q&A
SATTA MATKA SATTA FAST RESULT KALYAN TOP MATKA RESULT KALYAN SATTA MATKA FAST RESULT MILAN RATAN RAJDHANI MAIN BAZAR MATKA FAST TIPS RESULT MATKA CHART JODI CHART PANEL CHART FREE FIX GAME SATTAMATKA ! MATKA MOBI SATTA 143 spboss.in TOP NO1 RESULT FULL RATE MATKA ONLINE GAME PLAY BY APP SPBOSS
Event Report - SAP Sapphire 2024 Orlando - lots of innovation and old challengesHolger Mueller
Holger Mueller of Constellation Research shares his key takeaways from SAP's Sapphire confernece, held in Orlando, June 3rd till 5th 2024, in the Orange Convention Center.
Taurus Zodiac Sign: Unveiling the Traits, Dates, and Horoscope Insights of th...my Pandit
Dive into the steadfast world of the Taurus Zodiac Sign. Discover the grounded, stable, and logical nature of Taurus individuals, and explore their key personality traits, important dates, and horoscope insights. Learn how the determination and patience of the Taurus sign make them the rock-steady achievers and anchors of the zodiac.
Unveiling the Dynamic Personalities, Key Dates, and Horoscope Insights: Gemin...my Pandit
Explore the fascinating world of the Gemini Zodiac Sign. Discover the unique personality traits, key dates, and horoscope insights of Gemini individuals. Learn how their sociable, communicative nature and boundless curiosity make them the dynamic explorers of the zodiac. Dive into the duality of the Gemini sign and understand their intellectual and adventurous spirit.
The APCO Geopolitical Radar - Q3 2024 The Global Operating Environment for Bu...APCO
The Radar reflects input from APCO’s teams located around the world. It distils a host of interconnected events and trends into insights to inform operational and strategic decisions. Issues covered in this edition include:
How to Implement a Strategy: Transform Your Strategy with BSC Designer's Comp...Aleksey Savkin
The Strategy Implementation System offers a structured approach to translating stakeholder needs into actionable strategies using high-level and low-level scorecards. It involves stakeholder analysis, strategy decomposition, adoption of strategic frameworks like Balanced Scorecard or OKR, and alignment of goals, initiatives, and KPIs.
Key Components:
- Stakeholder Analysis
- Strategy Decomposition
- Adoption of Business Frameworks
- Goal Setting
- Initiatives and Action Plans
- KPIs and Performance Metrics
- Learning and Adaptation
- Alignment and Cascading of Scorecards
Benefits:
- Systematic strategy formulation and execution.
- Framework flexibility and automation.
- Enhanced alignment and strategic focus across the organization.
Brian Fitzsimmons on the Business Strategy and Content Flywheel of Barstool S...Neil Horowitz
On episode 272 of the Digital and Social Media Sports Podcast, Neil chatted with Brian Fitzsimmons, Director of Licensing and Business Development for Barstool Sports.
What follows is a collection of snippets from the podcast. To hear the full interview and more, check out the podcast on all podcast platforms and at www.dsmsports.net
Industrial Tech SW: Category Renewal and CreationChristian Dahlen
Every industrial revolution has created a new set of categories and a new set of players.
Multiple new technologies have emerged, but Samsara and C3.ai are only two companies which have gone public so far.
Manufacturing startups constitute the largest pipeline share of unicorns and IPO candidates in the SF Bay Area, and software startups dominate in Germany.
[To download this presentation, visit:
https://www.oeconsulting.com.sg/training-presentations]
This PowerPoint compilation offers a comprehensive overview of 20 leading innovation management frameworks and methodologies, selected for their broad applicability across various industries and organizational contexts. These frameworks are valuable resources for a wide range of users, including business professionals, educators, and consultants.
Each framework is presented with visually engaging diagrams and templates, ensuring the content is both informative and appealing. While this compilation is thorough, please note that the slides are intended as supplementary resources and may not be sufficient for standalone instructional purposes.
This compilation is ideal for anyone looking to enhance their understanding of innovation management and drive meaningful change within their organization. Whether you aim to improve product development processes, enhance customer experiences, or drive digital transformation, these frameworks offer valuable insights and tools to help you achieve your goals.
INCLUDED FRAMEWORKS/MODELS:
1. Stanford’s Design Thinking
2. IDEO’s Human-Centered Design
3. Strategyzer’s Business Model Innovation
4. Lean Startup Methodology
5. Agile Innovation Framework
6. Doblin’s Ten Types of Innovation
7. McKinsey’s Three Horizons of Growth
8. Customer Journey Map
9. Christensen’s Disruptive Innovation Theory
10. Blue Ocean Strategy
11. Strategyn’s Jobs-To-Be-Done (JTBD) Framework with Job Map
12. Design Sprint Framework
13. The Double Diamond
14. Lean Six Sigma DMAIC
15. TRIZ Problem-Solving Framework
16. Edward de Bono’s Six Thinking Hats
17. Stage-Gate Model
18. Toyota’s Six Steps of Kaizen
19. Microsoft’s Digital Transformation Framework
20. Design for Six Sigma (DFSS)
To download this presentation, visit:
https://www.oeconsulting.com.sg/training-presentations
Building Your Employer Brand with Social MediaLuanWise
Presented at The Global HR Summit, 6th June 2024
In this keynote, Luan Wise will provide invaluable insights to elevate your employer brand on social media platforms including LinkedIn, Facebook, Instagram, X (formerly Twitter) and TikTok. You'll learn how compelling content can authentically showcase your company culture, values, and employee experiences to support your talent acquisition and retention objectives. Additionally, you'll understand the power of employee advocacy to amplify reach and engagement – helping to position your organization as an employer of choice in today's competitive talent landscape.
How are Lilac French Bulldogs Beauty Charming the World and Capturing Hearts....Lacey Max
“After being the most listed dog breed in the United States for 31
years in a row, the Labrador Retriever has dropped to second place
in the American Kennel Club's annual survey of the country's most
popular canines. The French Bulldog is the new top dog in the
United States as of 2022. The stylish puppy has ascended the
rankings in rapid time despite having health concerns and limited
color choices.”
Anny Serafina Love - Letter of Recommendation by Kellen Harkins, MS.AnnySerafinaLove
This letter, written by Kellen Harkins, Course Director at Full Sail University, commends Anny Love's exemplary performance in the Video Sharing Platforms class. It highlights her dedication, willingness to challenge herself, and exceptional skills in production, editing, and marketing across various video platforms like YouTube, TikTok, and Instagram.
Zodiac Signs and Food Preferences_ What Your Sign Says About Your Tastemy Pandit
Know what your zodiac sign says about your taste in food! Explore how the 12 zodiac signs influence your culinary preferences with insights from MyPandit. Dive into astrology and flavors!
Best practices for project execution and deliveryCLIVE MINCHIN
A select set of project management best practices to keep your project on-track, on-cost and aligned to scope. Many firms have don't have the necessary skills, diligence, methods and oversight of their projects; this leads to slippage, higher costs and longer timeframes. Often firms have a history of projects that simply failed to move the needle. These best practices will help your firm avoid these pitfalls but they require fortitude to apply.
1. Biochempeg https://www.biochempeg.com
Large-Scale Monodisperse PEG Products
Biochempeg continuously expands its capability to provide large-scale manufacture of
high purity monodisperse PEG derivatives with an extensive variety of functional groups,
in both non-GMP and GMP grade.
Monodisperse PEG retains the good water solubility of polyethylene glycol, and provides
the same PEG benefits for PEGylated drugs, namely reducing aggregation and
immunogenicity, and increasing hydrodynamic volume.
The following are some examples of our monodisperse PEG products with
purity >95% that have been scaled up to kilogram scale batch size.
No. Cat.No Cas No. Name
1 MD003003-3 2781-02-4 SH-PEG3-SH