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Laparoscopic Trans-Hiatal Esophagectomy for Early Cancer Abeezar I. Sarela Department of Upper GI &  Minimally Invasive Surgery Leeds, UK
SAGES Presenter Disclosure Slide Abeezar I. Sarela Nothing To Disclose
Agenda Early Esophageal Carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is Early Esophageal Cancer? Superficial Esophageal Carcinoma Japanese Esophageal Society Esophagus 2009;6:1-25 T1a + T1b AJCC/TNM 7 th  Edition Early Esophageal Carcinoma Japanese Esophageal Society Esophagus 2009;6:1-25 T1a AJCC/TNM 7th Edition
pT1 Esophageal Carcinoma Depth of primary tumor and lymph node metastasis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Stein et al. Ann Surg 2005;242:566-573
Subclassification of Depth of Invasion by Superficial Carcinoma of the Esophagus in Surgically Resected Specimens Endoscopic Resection Specimens sm1 carcinoma: invades less than 200 microns into the submucosa Japanese Esophageal Society. Japanese Classification of Esophageal Cancer. !0 th  Ed. Esophagus 2009;6:1-25
Relationship between Depth of Invasion and Lymph Node Metastasis in  Superficial Squamous Carcinoma Takubo et al. Histopathology 2007;51:733-742
Relationship between Depth of Invasion and Lymph Node Metastasis in  Superficial Adenocarcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Westerterp et al. Virchows Arch 2005;446:497-504
Oncological Outcomes   Esophagectomy for pT1 Adenocarcinoma Saha et al. Surg Endosc 2009;23:119-124 40 patients - T1b 11 patients - N1 20% of T1b - Poor differentiation 4 patients Liver 22 N0 Poor T1a Trans-thoracic Liver 8 N1 Poor T1b Trans-thoracic Nodes 6 N0 Poor T1b Trans-Hiatal Site of recurrence Time to recurrence Node status Differentiation Tumor Depth Operation
Diagnosis and Staging of  Early (T1a) and  Superficial (T1a+T1b) Esophageal Carcinoma
Endoscopic Diagnosis of  Early Esophageal Carcinoma Fujinon “FICE” Olympus “Tri-Modality”
Can we predict the risk of lymph node metastasis? 27% 50% 20% 10% 10% Incidence of nodal metastasis Takubo et al. Histopathology 2007;51:733-742
High Risk Factors for  Lymph Node Metastasis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Takubo et al. Histopathology 2007;51:733-742
Endoscopic Ultrasound (EUS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Endoscopic Mucosal Resection ,[object Object],[object Object]
Emerging Treatment Paradigm  EMR of all resectable dysplastic lesions Favourable histology? Multifocality? Ablation of the remaining Barrett‘s - ?RFA Endoscopic Surveillance
Indications for Esophagectomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transhiatal  vs.  Transthoracic? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Hulscher et al. N Eng J Med 2002;347:1662-9; Omloo et al. Ann Surg 2007;246:992-1000
Laparoscopic Transhiatal Esophagectomy ,[object Object],[object Object],[object Object],[object Object],[object Object],Decker et al. European Journal of Cardio-Thoracic Surgery. 2009;35:13-21
Laparoscopic Esophagectomy Transhiatal vs. Transthoracic Decker et al. European Journal of Cardio-Thoracic Surgery. 2009;35:13-21 17 (7-62) 10 (5-15) Lymph node count 2.4% 4.6% Mortality 6.8% 3% Re-operation 22% 22% Respiratory complic. 7.6% 13% Leakage 6.4% 10% Vocal cord palsy Transthoracic 1499 patients Transhiatal 433 patients
What is the Aim of Esophagectomy? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laparoscopic Vagus-Sparing Esophagectomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Peyre et al. Ann Surg 2007;246:665-671 DeMeester S. Personal communication, 2010
Segmental Resection of the Gastroesophageal Junction and Reconstruction with a Pedicled Flap of Jejunum (Merindino Operation) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Stein et al. Ann Surg 2000;232:733-742
 
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Laparoscopic trans hiatal esophagectomy for early cancer-final

  • 1. Laparoscopic Trans-Hiatal Esophagectomy for Early Cancer Abeezar I. Sarela Department of Upper GI & Minimally Invasive Surgery Leeds, UK
  • 2. SAGES Presenter Disclosure Slide Abeezar I. Sarela Nothing To Disclose
  • 3.
  • 4. What is Early Esophageal Cancer? Superficial Esophageal Carcinoma Japanese Esophageal Society Esophagus 2009;6:1-25 T1a + T1b AJCC/TNM 7 th Edition Early Esophageal Carcinoma Japanese Esophageal Society Esophagus 2009;6:1-25 T1a AJCC/TNM 7th Edition
  • 5.
  • 6. Subclassification of Depth of Invasion by Superficial Carcinoma of the Esophagus in Surgically Resected Specimens Endoscopic Resection Specimens sm1 carcinoma: invades less than 200 microns into the submucosa Japanese Esophageal Society. Japanese Classification of Esophageal Cancer. !0 th Ed. Esophagus 2009;6:1-25
  • 7. Relationship between Depth of Invasion and Lymph Node Metastasis in Superficial Squamous Carcinoma Takubo et al. Histopathology 2007;51:733-742
  • 8.
  • 9. Oncological Outcomes Esophagectomy for pT1 Adenocarcinoma Saha et al. Surg Endosc 2009;23:119-124 40 patients - T1b 11 patients - N1 20% of T1b - Poor differentiation 4 patients Liver 22 N0 Poor T1a Trans-thoracic Liver 8 N1 Poor T1b Trans-thoracic Nodes 6 N0 Poor T1b Trans-Hiatal Site of recurrence Time to recurrence Node status Differentiation Tumor Depth Operation
  • 10. Diagnosis and Staging of Early (T1a) and Superficial (T1a+T1b) Esophageal Carcinoma
  • 11. Endoscopic Diagnosis of Early Esophageal Carcinoma Fujinon “FICE” Olympus “Tri-Modality”
  • 12. Can we predict the risk of lymph node metastasis? 27% 50% 20% 10% 10% Incidence of nodal metastasis Takubo et al. Histopathology 2007;51:733-742
  • 13.
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  • 16. Emerging Treatment Paradigm EMR of all resectable dysplastic lesions Favourable histology? Multifocality? Ablation of the remaining Barrett‘s - ?RFA Endoscopic Surveillance
  • 17.
  • 18.
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  • 20. Laparoscopic Esophagectomy Transhiatal vs. Transthoracic Decker et al. European Journal of Cardio-Thoracic Surgery. 2009;35:13-21 17 (7-62) 10 (5-15) Lymph node count 2.4% 4.6% Mortality 6.8% 3% Re-operation 22% 22% Respiratory complic. 7.6% 13% Leakage 6.4% 10% Vocal cord palsy Transthoracic 1499 patients Transhiatal 433 patients
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  • 25.