1) Esophageal cancer is often discovered late and has an overall 5-year prognosis of less than 10%. Even for potentially resectable esophageal cancer, 5-year survival is less than 30%. 2) The most common benign esophageal tumor is leiomyoma, which typically causes dysphagia or hematemesis if large. Malignant esophageal tumors are usually adenocarcinoma or squamous cell carcinoma. 3) Risk factors for squamous cell carcinoma include alcohol, tobacco, HPV infection, radiation exposure, and achalasia. Symptoms include progressive dysphagia and weight loss. Diagnosis involves endoscopy with biopsy. Treatment depends on cancer staging and