Lactic Acidosis & Critical Care - PGIMER
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This document discusses lactic acidosis, including its normal production through anaerobic breakdown of glucose in tissues. It notes normal and elevated lactate levels. It also covers major producers and consumers of lactate through the Cori cycle, common causes of lactic acidosis like shock, different types of lactic acidosis, the Warburg effect in tumor cells, diagnosis, and treatment approaches including the role of sodium bicarbonate and surviving sepsis guidelines.
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- 2. ??? Lactate & Lactic acidosis Major producers and consumers of lactate Cori cycle Causes of lactic acidosis Types of lactic acidosis Warburg effect Diagnosis Treatment Role of NaHCO3 Surviving sepsis guidelines: Bundles
- 3. Normal end point of anaerobic breakdown of glucose in the tissues Normal plasma lactate: ➢ Unstressed: 0.5-1 mmol/L ➢ Stressed: < 2 mmol/L ➢ Hyperlactatemia: 2-5 mmol/L ➢ Lactic acidosis: usually > 5 mmol/L with associated metabolic acidosis
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- 53. SHOOT YOUR ANSWERS Lactate & Lactic acidosis Major producers and consumers of lactate Cori cycle Causes of lactic acidosis Types of lactic acidosis Warburg effect Diagnosis Treatment Role of NaHCO3 Surviving sepsis guidelines: Bundles
- 54. THANK YOU