Restless legs syndrome (RLS) is a condition characterized by an uncomfortable sensation in the legs and a desire to move them, especially at night or during periods of inactivity. It is often underdiagnosed. RLS symptoms include unusual sensations deep in the legs along with overt restless leg movements that are worse at rest and may be temporarily relieved by movement. Periodic leg movements of sleep (PLMS) often accompany RLS and involve abrupt leg movements during sleep. While there is no cure, treatment with dopamine-boosting medications can reduce symptoms and improve functioning.
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Un matrimonio anomalo a Pavia al quale ho dovuto partecipare, ma non vi preoccupate mi ero vaccinato prima, non sono stato infettato dal MalPadano...anzi. Aflo
Social Media is a moving target for companies. More and more platforms and options arise every day. Engagement Media helps you to find your way through the social media galaxy (or jungle) by analyzing digital trends on a day to day basis. This presentation shows you 8 of over 20 trends in Social Media. Want an update on State-of-the-Art social media trends? contact us.
Daylight Savings Time 2012 - At 2 a.m. on the morning of Sunday, March 11, we'll be springing our clocks forward—and losing an hour of the day, for Daylight Saving Time. The good news: sunset will be an hour later
Daylight Savings Time - You may have noticed the annual tradition of Daylight Saving Time has crept forward a bit. We used to spring forward on the first Sunday in April and fall back on last Sunday in October. But a couple years ago, Congress changed the date—adding more Daylight Saving Time to the calendar. This year, it will run from March 11 until Nov. 4.
Big East Basketball - Pittsburgh and Seton Hall also advanced to the second round. Pitt won 73-59 against St. John’s as Ashton Gibbs scored 20 points for the Panthers, and Seton Hall got 16
Clonazepam vs xanax information . elow is some information on Clonazepam, though not a complete summary on this medication. This information is provided to assist you with facts before you start taking this medication.
Zoloft weight gain information - If you are overweight and have been prescribed an antidepressant to provide you with the lift that you need to get your body and life back in order then you may be doing yourself more harm than good. The irony is that almost all antidepressants and anti-psychotic medications have weight gain as a side effect.
Social Media is a moving target for companies. More and more platforms and options arise every day. Engagement Media helps you to find your way through the social media galaxy (or jungle) by analyzing digital trends on a day to day basis. This presentation shows you 8 of over 20 trends in Social Media. Want an update on State-of-the-Art social media trends? contact us.
Daylight Savings Time 2012 - At 2 a.m. on the morning of Sunday, March 11, we'll be springing our clocks forward—and losing an hour of the day, for Daylight Saving Time. The good news: sunset will be an hour later
Daylight Savings Time - You may have noticed the annual tradition of Daylight Saving Time has crept forward a bit. We used to spring forward on the first Sunday in April and fall back on last Sunday in October. But a couple years ago, Congress changed the date—adding more Daylight Saving Time to the calendar. This year, it will run from March 11 until Nov. 4.
Big East Basketball - Pittsburgh and Seton Hall also advanced to the second round. Pitt won 73-59 against St. John’s as Ashton Gibbs scored 20 points for the Panthers, and Seton Hall got 16
Clonazepam vs xanax information . elow is some information on Clonazepam, though not a complete summary on this medication. This information is provided to assist you with facts before you start taking this medication.
Zoloft weight gain information - If you are overweight and have been prescribed an antidepressant to provide you with the lift that you need to get your body and life back in order then you may be doing yourself more harm than good. The irony is that almost all antidepressants and anti-psychotic medications have weight gain as a side effect.
Klonopin xr data - One of the most severe psychiatric disorders is the bipolar disorder. This is a condition of alternating periods of high creativity and energy, mania and depression with varying degrees of severity.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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While I was still in training to become a neurologist, I got excited when I made a diagnosis of Ekbom's
syndrome, as RLS was then known. In those days, the condition seemed rare and exotic, something a doctor
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2. syndrome, as RLS was then known. In those days, the condition seemed rare and exotic, something a doctor
almost never encountered.
Nowadays, in my community practice of neurology, I see cases of RLS almost every day. So where were all
these people 25 years ago? Unless the disease has suddenly started propagating like mad, one has to
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conclude that previously the patients weren't talking, the doctors weren't listening- - or both.
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Estimates of the prevalence of this condition vary widely, but in a large study conducted in five European
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countries, 5.5% of the population over the age of 14 had this condition. RLS occurs in both genders, but is
slightly more frequent in women. RLS occurs at any age- - including in childhood- - but becomes more Games
common with advancing years.
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Although there is now much more awareness of restless legs syndrome among doctors and patients alike, it Cars
is still often underdiagnosed or misdiagnosed. For example, a child's symptoms might get misdiagnosed as
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What are the usual symptoms? In 1995 an international conference of experts agreed upon the following
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#1. There is a desire to move the legs in association with unusual or uncomfortable sensations deep within
the legs;
#2. There are overt restless movements in a response to or in an effort to relieve the unusual sensations or
discomfort;
#3. Symptoms are worse or exclusively present at rest (inactivity or relaxation) and might be temporarily
improved by voluntary movements of the affected limbs; and
#4. Symptoms occur most frequently during the evening or early part of the night.
In addition, most people who have restless legs syndrome also have " periodic leg movements of sleep" or
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3. PLMS, previously abbreviated as PMS, but this was, uh, confusing. PLMS refers to abrupt, brief leg
movements, generally affecting both legs, and which occur repeatedly during the first several hours of
sleep.
The person with PLMS might know only that their bedclothes are a mess the next morning. However, the
spouse or other sleeping partner might experience disruption of their own sleep by the movements.
Sometimes they relocate to another bed because of them.
The usual course of RLS is that the condition is present for life, and can worsen over time. RLS and PLMS
are among those conditions described as due to a " chemical imbalance" in the brain. The abnormality does
not show up on MRI scans, CT scans, electroencephalograms (EEGs), spinal taps or blood tests.
Although no cure yet exists, treatment can reduce symptoms and improve function. While medications are
the mainstay of treatment, many patients find that physical maneuvers improve their symptoms, like rubbing
their legs or periodically getting up and walking around.
Choice of medication depends on what else is going on with the patient. In some cases the RLS is due to
another condition in need of its own treatment, like iron deficiency, anemia, diabetes, nerve damage or
advanced kidney disease. Pregnancy can also induce RLS, though in this situation the symptoms usually
resolve after the woman delivers.
The most common form of RLS occurs without evidence of a second, underlying condition, except for a
possible genetic link to relatives with RLS. In these patients drugs that boost dopamine- - one of the brain's
chemical transmitters- - are the first choice. These are the same drugs used in Parkinson's disease, another
condition in which dopamine is in short supply. However, for the most part, the two diseases are otherwise
unrelated.
Dopamine- blocking drugs- - comprising most of the anti- nausea and anti- psychotic medications- - can have
the unintended consequence of worsening symptoms. For example, in the author's practice, a young
woman with RLS went to an emergency room because of a migraine attack. She received an intravenous
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4. dose of the dopamine- blocker promethaz ine (brand name Phenergan) and this made her legs acutely
restless and uncomfortable. In another case, an elderly woman with memory loss and agitation received
risperidone (Risperdal) and this caused RLS symptoms that had not been present previously.
Certain drugs that also serve as anticonvulsants, like gabapentin (Neurontin) and clonaz epam (Klonopin),
can help. Painkillers also work, and probably do so by interacting with a specific set of painkiller receptors
in the brain, rather than just dulling symptoms. However, because treatment is generally needed over a
long period of time, painkillers are not the usual treatments of first choice.
This essay only brushes the surface of this fascinating condition. To learn more, visit the website of the aptly
named We Move organiz ation.
(C) 2005 by Gary Cordingley
Gary Cordingley, MD, PhD, is a clinical neurologist, teacher and researcher. For more health- related articles
see his website at: http://www.cordingleyneurology.com
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5. RLS and PLMS might look like alphabet soup, but to millions of people with
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