A lecture by Dr/ Ahmad Nofal deسcribing the clinical features of Kindler syndrome.

1. Kindler syndrome:
Report of 12 cases and proposed
diagnostic criteria
Nofal A., Nofal E. Yosef A., Amer H., Alakad R.,
Albalat W., Gharib K., Eldesouky F.
Faculty of Medicine, Zagazig University,
Dermatology Department, Egypt

2. Kindler Syndrome (KS) is a rare AR
genodermatosis characterized by 4 major &
many minor features.
The clinical features remain the
mainstay in the diagnosis of KS.
Introduction

3. present 12 cases of KS, discuss its
different clinical presentations
and propose new diagnostic
criteria for this rare syndrome.
Objectives

4. Twelve patients with clinical features
consistent with KS were included in this
study.
 Complete clinical examination
 Histopathological and EM examinations
 Genetic studies were unavailable
Patients and methods

5. • Parental consanguinity was positive in 9
cases.
• The age ranged from 9 months-23 years.
• Two patients were sisters, two were
brothers and the other eight were
sporadic cases.
Results

6. 0
1
2
3
4
5
6
7
8
PPK Finger
webbing
nail
dystrophy
dental gingival stenosis deafness skeletal ectropion physical
and
mental
hair and
sweat
Results

7. Cutaneous
atrophy
Acral
blisters
PhotosensitivityPoikiloderma
Constant Features

19. Constant features

20. Variable Features

30. Variable features

31. Clinical features still have the central
place in the diagnosis of KS.
Diagnostic clinical criteria to simplify
the diagnosis, to make the syndrome more
strictly defined and to avoid missing cases.
Conclusion

32. Conclusion
Constant
Features
Variable
Features

33. Conclusions
MMR and BCG vaccines seem to be
promising effective and safe treatment
modalities for common warts, including
single, multiple and recalcitrant variants.
 They are inexpensive
 The advantages of widespread and
sustained effects against HPV.
Thank you