Ibuprofen was developed in the 1960s by Boots Group researchers including Stewart Adams. It was licensed for treating rheumatoid arthritis in the UK and US. Boots held the patent until 1985 and marketing rights until 1986, after which generic brands were created. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is legal and available under many brand names. Side effects can include gastrointestinal issues, but overdose can cause seizures, cardiac problems, and even death.

2. HistoryHistory
 Developed by the Boots Group in the 1960’sDeveloped by the Boots Group in the 1960’s
 Made by Stewart Adams, John Nicholson, AndrewMade by Stewart Adams, John Nicholson, Andrew
RM Dunlop, Jeffrey Bruce Wilson, and ColinRM Dunlop, Jeffrey Bruce Wilson, and Colin
BurrowsBurrows
 Treated rheumatoid arthritis in the UK and the USTreated rheumatoid arthritis in the UK and the US
 Won Stewart Adams an OBE and the Boots GroupWon Stewart Adams an OBE and the Boots Group
the Queen’s ATA for Ibuprofen’s developmentthe Queen’s ATA for Ibuprofen’s development
 The Boots Group originally licensed Ibuprofen toThe Boots Group originally licensed Ibuprofen to
Whitehall Laboratories and UpjohnWhitehall Laboratories and Upjohn
 Boots had the patent until 1985, and marketingBoots had the patent until 1985, and marketing
rights until 1986rights until 1986
 New “generic” brands were createdNew “generic” brands were created
 The Sterling Drugs company made Midol 200The Sterling Drugs company made Midol 200

3. Classification and NicknamesClassification and Nicknames
 NSAIDNSAID
 Some Brand namesSome Brand names::
 Addaprin®Addaprin®
 Advil®Advil®
 Dayquil®Dayquil®
 Ibifon 600®Ibifon 600®
 Ibren®Ibren®
 Menadol®Menadol®
 Midol®Midol®
 Motrin®Motrin®
 Nuprin®Nuprin®
 Q-Profen®Q-Profen®
 Tab-Profen®Tab-Profen®
 Uni-Pro®Uni-Pro®
 Wal-Profen®Wal-Profen®

4. Side Effects And LegalitySide Effects And Legality
 LegalLegal
 Side effects:Side effects:
 ConstipationConstipation
 DiarrheaDiarrhea
 DizzinessDizziness
 NervousnessNervousness
 Unexplained weight gainUnexplained weight gain
 FeverFever
 ItchingItching
 HivesHives
 Excessive tirednessExcessive tiredness
 Loss of appetiteLoss of appetite
 Pale skinPale skin
 Back painBack pain
 Vision problemsVision problems
 HeadacheHeadache
 ConfusionConfusion

5. Possible DangersPossible Dangers
 Dangers:Dangers:
 NauseaNausea
 HeartburnHeartburn
 Gastrointestinal problemsGastrointestinal problems
 HeadacheHeadache
 DizzinessDizziness
 SleepinessSleepiness
 Can be minor/severeCan be minor/severe
 Someone with theseSomeone with these
symptoms should stopsymptoms should stop
taking ibuprofen, or talk totaking ibuprofen, or talk to
their doctortheir doctor
 Cut back on your dosage,Cut back on your dosage,
or switch your painor switch your pain
medicationmedication
 Bad enough=SeizuresBad enough=Seizures
Taking ibuprofen for toTaking ibuprofen for to
long may result in:long may result in:
Chest painsChest pains
Heart problemsHeart problems
Gastrointestinal problemsGastrointestinal problems
Liver problemsLiver problems
Kidney problemsKidney problems
Which can lead to:Which can lead to:
WeaknessWeakness
Shortness of breathShortness of breath
Slurred speechSlurred speech
Problems with vision orProblems with vision or
balancebalance
Coughing up blood orCoughing up blood or
vomitvomit
Rapid weight gainRapid weight gain

6. OverdosageOverdosage
 Symptoms of overdosage:Symptoms of overdosage:
 DizzinessDizziness
 Fast eye movementsFast eye movements
 Slow breathingSlow breathing
 Blue color around the lips, mouth,Blue color around the lips, mouth,
and noseand nose
 Overdosage has become commonOverdosage has become common
since it became over-the-countersince it became over-the-counter
 Overdosage symptoms include:Overdosage symptoms include:
 Abdominal painAbdominal pain
 NauseaNausea
 VomitingVomiting
 DrowsinessDrowsiness
 DizzinessDizziness
 HeadacheHeadache
 More severe symptoms:More severe symptoms:
 Gastrointestinal bleedingGastrointestinal bleeding
 SeizuresSeizures
 Metabolic acidosisMetabolic acidosis
 HyperkalaemiaHyperkalaemia
 HypotensionHypotension
 BradycardiaBradycardia
 TachycardiaTachycardia
Atrial fibrillationAtrial fibrillation
ComaComa
Hepatic dysfunctionHepatic dysfunction
Acute renal failureAcute renal failure
CyanosisCyanosis
Respiratory depressionRespiratory depression
Cardiac arrestCardiac arrest
Toxic around 100 mg/kg aboveToxic around 100 mg/kg above
400 mg/kg400 mg/kg
Deadly amount will varyDeadly amount will vary
Ways to help an overdosage:Ways to help an overdosage:
Stomach pumpingStomach pumping
Therapy for low blood pressureTherapy for low blood pressure
Gastrointestinal bleeding treatmentGastrointestinal bleeding treatment
Acidosis treatmentsAcidosis treatments
Therapy for renal toxicityTherapy for renal toxicity
The overdose patient will be closelyThe overdose patient will be closely
monitored in an intensive care unitmonitored in an intensive care unit