This presentation is an overview of GlaxoSmithkline,with a detailed review of its best-selling product, Advair. This project was presented as part of an assignment for the Introduction to Biotech Industry course at Georgetown University.

1. Improving Health and Quality of Life
Do More, Feel Better, Live Longer
Zuhal Tompkins
Raman Goyal
Ramola Chendvankar
Ruchi Shah
Elias Sobrino

2. AGENDA:
Introduction / Company Overview
Zuhal Tompkins, CEO
Research and Development
Ramola Chendvankar, CSO
Raman Goyal, CSO
Marketing and Commercialization
Ruchi Shah, CCO
Financial Outlook
Elias Sobrino, CFO
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3. GSK Overview
• The world's second largest pharmaceutical company
• Headquartered in the UK and with operations based in the US
• ZANTAC
• 40 plants throughout the world
• Presence in almost 100 countries
• Listed on London and New York stock exchanges.
• Revenue of £22.7 billion
• Net Income of £7.8 billion in 2007
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4. History / Mile Stones of
GSK
1830 - John K Smith opens his first drugstore in
Philadelphia.
1842 - Thomas Beecham launches the Beecham’
Pills business in England.
1873 - Joseph Nathan establishes Joseph Nathan
and Company, the foundation for the Glaxo
Company to be formed later.
1881 - Burroughs Wellcome & Company is
established in London
1989 - SmithKline and Beecham merge to form
SmithKline Beecham.
1995 - Glaxo and Wellcome merge to form Glaxo
Wellcome.
2001 - GlaxoSmithKline is formed by the merger of
Glaxo Wellcome and SmithKline Beecham.
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5. Our Mission
Our global quest is to improve the quality of human life by enabling
people to do more, feel better, and live longer.
Our Strategy
Our strategy is to strive for excellence in the following five key areas of our
business:
1. Optimising the performance of key products
– achieving worldwide sales force excellence
– achieving Pharmaceutical and Consumer Healthcare marketing
excellence
– maintaining the highest ethical standards (intellectual property )
– improving the cost-effectiveness of operations
2. Delivering the product pipeline for patients
3. Being the best place for the best people to do their best work
4. Improving access to medicines
5. Maximising total shareholder return (TSR)
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6. Andrew Philip Witty - CEO
Chief Executive Officer on 21 May 2008
Joined Glaxo in 1985
Held a variety of roles in the UK business
from sales representative to Director of
Pharmacy and Distribution.
43-year-old
WITTY’s GOALS
Plans to radically alter GSK’s R&D work
Shifting more to a biotech approach
Set up a venture arm to invest in promising
Base Salary: new therapies
$1.7 million
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7. Extensive Pipeline
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8. Improving Health and Quality of Life Do More, Feel Better, Live Longer

9. Improving Health and Quality of Life
Do More, Feel Better, Live Longer
Research and Development
Raman Goyal
Ramola Chendvankar

10. Improving Health and Quality of Life Do More, Feel Better, Live Longer

11. What is Asthma???
Chronic inflammatory disorder
of the airways.
Can be controlled and treated.
Not the same as allergies.
Not contagious.
Increased bronchial hyper
responsiveness to a variety of
stimuli.
Improving Health and Quality of Life Do More, Feel Better, Live Longer

12. Symptoms and Severity of Asthma
 Symptoms of asthma Severity of asthma
Coughing Mild intermittent
Shortness of breath Mild persistent
Wheezing Moderate persistent
Tight chest/chest pain Severe persistent
In severe cases asthma can be
deadly
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13. Causes of Asthma
Causes of Asthma:
UNKNOWN
Asthma triggers:
Inhaled allergens(specific).
Irritants(non specific).
Contaminants.
Genetic factors.
Improving Health and Quality of Life Do More, Feel Better, Live Longer

14. Improving Health and Quality of Life Do More, Feel Better, Live Longer

15. Diagnosis of Asthma
Pulmonary Function Tests.
(VC,PEFR,FEV1)
Allergy Test.
Other Tests(Blood count, chest
and sinus xrays, CT scans etc).
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16. Asthma Medications
RELIEVERS: CONTROLLERS:
(Relaxes airways) (Decreases swelling and mucus)
examples: examples:
Ventolin Pulmicort
Bricanyl Prednisone
Airomir SEREVENT
Salbutamol Accolate
COMBINATION
MEDICATION:
ADVAIR
Symbicort
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17. Advair Diskus
• ADVAIR DISKUS first dual acting
asthma medication Approved for use in
the US.
• ADVAIR DISKUS is a combination
product containing a corticosteroid and
a long-acting beta2-adrenergic agonist
• ADVAIR DISKUS acts on the 2 main
components of asthma
• Inflammation
• Constriction of the artery.
• Advair reduces exacerbation in COPD
by 30%
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18. Chronic Obstructive Pulmonary
Disease (COPD)
Improving Health and Quality of Life Do More, Feel Better, Live Longer

19. Components of ADVAIR DISKUS
Fluctisone propionate Salmetrol
• Corticosteroid • B2 adrenogonist
• Anti inflammatory activity. • Activates adenyl cyclase
• Inhibits the release of mucus • ATP to cyclic AMP
• Reduce swelling • Relaxation of bronchial
• Breathing Easier muscles
• Breathing easier
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20. Advair Diskus Vs Its individual
components
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21. Composition of Advair diskus
• Disposible purple device 60 blisters
Composition
• Advair Diskus 100/50
• Advair Diskus 250/50
• Advair Diskus 500/50
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22. How to use Advair Diskus
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23. Improving Health and Quality of Life
Do More, Feel Better, Live Longer
Marketing and Commercialization
Ruchi Shah, CCO

24. Strategy
• Well-positioned to peers.
• Broad-based, geographically-diverse and well-balanced business.
• Improved pipeline productivity.
• Reduce expenditure, work closely with customers.
• Use opportunities in the growing healthcare economies.
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25. Our Products
• Prescription medicines: Treatments for
asthma, HIV/AIDS, malaria, depression, migraine, diabetes, hea
rt failure, digestive conditions and cancer.
• Vaccines: Over 25 vaccines to protect against illnesses such as
hepatitis A and B, diphtheria, tetanus, whooping cough, typhoid
and influenza.
• Consumer healthcare: Dental health products, over-the-counter
medicines and nutritional drinks. Ex. Panadol, Aquafresh, and
Lucozade.
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26. Our top selling products in 2007
Product Turnover
Seretide/Advair 3.5 £b
Vaccines 2.0 £b
Valtrex 934 £m
Lucozade 347 £m
Requip 346 £m
Aquafresh 308 £m
Sensodyne 293 £m
Panadol 262 £m
Horlicks 174 £m
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28. Products of Companies in Phases of
Development
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29. Intellectual Property
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30. Trademark & In-licensing
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31. Competitors
Diagnose GSK’s Product Competitor and Its
Product
CNS Disorders Paxil Prozac (Eli Lilly)
Zoloft (Pfizer)
Celexa(Forest GSK AZN MRK
Laboratories)
Imigran Maxalt (Merck)
Advair Symbicort Singulair
Respiratory Advair Singular (Merck)
Serevent Symbicort (AstraZeneca) $ 6.9 billion $1.6 Billion (2007 $4.3 billion
Flixotide Spriva(Pfizer) launched)
Anti-bacterials Augmentin Zithromax (Pfizer) long-acting beta long-acting beta leukotriene
Amoxil Cipro (Bayer) antagonist antagonist receptor
Levaquin (J&J) antagonist
Anti-malarials Malarone 4 years old and up 4 years old and up use in children
Anti-viral Retrovir Famvir (Novartis) Relatively slow slightly faster cannot be used to
Epivir Aciclovir action then Advair treat acute asthma
Combivir
Ziagen attacks
Agenerase Effective Effective less effective than
Trizivir ICSs
Valtrex
Zovirax
Vaccines Angerix-B Comvax(Merck)
Havrix Recombivax HB
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32. SWOT Analysis
Strengths Weaknesses
Strong sales growth forecast from launch portfolio in the An aging portfolio of products heavily exposed to
2006-2012 period generic competition
Extensive early to mid stage R&D pipeline driven by High dependence on respiratory and CNS therapy
CEDD markets (low growth)
Vast sales and marketing force through mergers Failure to diversify and strengthen product portfolio and
Strong capability, leadership and experience in lack of novel product launches since 2002
pharmaceutical management strategies Impact of safety issues relating to Avandia
Positive Cash Reserves Recently expired patents
Opportunities
Threats
CEDD’s potential to deliver strong sales growth in the
Anticipated high exposure to generic competition over
future as demonstrated by launch portfolio forecast
the 2006-2012 period
Product launches such as Tykerb and Cervarix (high
Forecast negative sales growth performance over the
growth oncology market)
2006-2012 could drive leadership to change business
Recent Cost cutting initiatives model
Strong forecast sales growth from vaccine products in Strong competition over the next four years
the 2006-2012 period could support performance of non-
Large scale M&A activity
vaccine pharma products
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33. Improving Health and Quality of Life
Do More, Feel Better, Live Longer
Financials
Elilas Sobrino, CFO

34. Income Statement
Improving Health and Quality of Life Do More, Feel Better, Live Longer

35. Balance Sheet

36. Cash Flow
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37. Key facts
• Every second...
we distribute more than 35 doses of vaccine
• Every minute...
more than 1,100 prescriptions are written for GSK products
• Every hour...
we spend more than £300,000 (US$562,000) to find new
medicines
• Every day...
more than 200 million people around the world use a GSK brand
toothbrush or toothpaste
• Every year...
our factories produce 9 billion Tums tablets, 6 billion Panadol
tablets and 600 million tubes of toothpaste
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