GlaxoSmithkline

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This presentation is an overview of GlaxoSmithkline,with a detailed review of its best-selling product, Advair. This project was presented as part of an assignment for the Introduction to Biotech Industry course at Georgetown University.

GlaxoSmithkline

  1. 1. Improving Health and Quality of Life Do More, Feel Better, Live Longer Zuhal Tompkins Raman Goyal Ramola Chendvankar Ruchi Shah Elias Sobrino
  2. 2. AGENDA: Introduction / Company Overview Zuhal Tompkins, CEO Research and Development Ramola Chendvankar, CSO Raman Goyal, CSO Marketing and Commercialization Ruchi Shah, CCO Financial Outlook Elias Sobrino, CFO Improving Health and Quality of Life Do More, Feel Better, Live Longer
  3. 3. GSK Overview • The world's second largest pharmaceutical company • Headquartered in the UK and with operations based in the US • ZANTAC • 40 plants throughout the world • Presence in almost 100 countries • Listed on London and New York stock exchanges. • Revenue of £22.7 billion • Net Income of £7.8 billion in 2007 Improving Health and Quality of Life Do More, Feel Better, Live Longer
  4. 4. History / Mile Stones of GSK 1830 - John K Smith opens his first drugstore in Philadelphia. 1842 - Thomas Beecham launches the Beecham’ Pills business in England. 1873 - Joseph Nathan establishes Joseph Nathan and Company, the foundation for the Glaxo Company to be formed later. 1881 - Burroughs Wellcome & Company is established in London 1989 - SmithKline and Beecham merge to form SmithKline Beecham. 1995 - Glaxo and Wellcome merge to form Glaxo Wellcome. 2001 - GlaxoSmithKline is formed by the merger of Glaxo Wellcome and SmithKline Beecham. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  5. 5. Our Mission Our global quest is to improve the quality of human life by enabling people to do more, feel better, and live longer. Our Strategy Our strategy is to strive for excellence in the following five key areas of our business: 1. Optimising the performance of key products – achieving worldwide sales force excellence – achieving Pharmaceutical and Consumer Healthcare marketing excellence – maintaining the highest ethical standards (intellectual property ) – improving the cost-effectiveness of operations 2. Delivering the product pipeline for patients 3. Being the best place for the best people to do their best work 4. Improving access to medicines 5. Maximising total shareholder return (TSR) Improving Health and Quality of Life Do More, Feel Better, Live Longer
  6. 6. Andrew Philip Witty - CEO Chief Executive Officer on 21 May 2008 Joined Glaxo in 1985 Held a variety of roles in the UK business from sales representative to Director of Pharmacy and Distribution. 43-year-old WITTY’s GOALS Plans to radically alter GSK’s R&D work Shifting more to a biotech approach Set up a venture arm to invest in promising Base Salary: new therapies $1.7 million Improving Health and Quality of Life Do More, Feel Better, Live Longer
  7. 7. Extensive Pipeline Improving Health and Quality of Life Do More, Feel Better, Live Longer
  8. 8. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  9. 9. Improving Health and Quality of Life Do More, Feel Better, Live Longer Research and Development Raman Goyal Ramola Chendvankar
  10. 10. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  11. 11. What is Asthma??? Chronic inflammatory disorder of the airways. Can be controlled and treated. Not the same as allergies. Not contagious. Increased bronchial hyper responsiveness to a variety of stimuli. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  12. 12. Symptoms and Severity of Asthma  Symptoms of asthma Severity of asthma Coughing Mild intermittent Shortness of breath Mild persistent Wheezing Moderate persistent Tight chest/chest pain Severe persistent In severe cases asthma can be deadly Improving Health and Quality of Life Do More, Feel Better, Live Longer
  13. 13. Causes of Asthma Causes of Asthma: UNKNOWN Asthma triggers: Inhaled allergens(specific). Irritants(non specific). Contaminants. Genetic factors. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  14. 14. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  15. 15. Diagnosis of Asthma Pulmonary Function Tests. (VC,PEFR,FEV1) Allergy Test. Other Tests(Blood count, chest and sinus xrays, CT scans etc). Improving Health and Quality of Life Do More, Feel Better, Live Longer
  16. 16. Asthma Medications RELIEVERS: CONTROLLERS: (Relaxes airways) (Decreases swelling and mucus) examples: examples: Ventolin Pulmicort Bricanyl Prednisone Airomir SEREVENT Salbutamol Accolate COMBINATION MEDICATION: ADVAIR Symbicort Improving Health and Quality of Life Do More, Feel Better, Live Longer
  17. 17. Advair Diskus • ADVAIR DISKUS first dual acting asthma medication Approved for use in the US. • ADVAIR DISKUS is a combination product containing a corticosteroid and a long-acting beta2-adrenergic agonist • ADVAIR DISKUS acts on the 2 main components of asthma • Inflammation • Constriction of the artery. • Advair reduces exacerbation in COPD by 30% Improving Health and Quality of Life Do More, Feel Better, Live Longer
  18. 18. Chronic Obstructive Pulmonary Disease (COPD) Improving Health and Quality of Life Do More, Feel Better, Live Longer
  19. 19. Components of ADVAIR DISKUS Fluctisone propionate Salmetrol • Corticosteroid • B2 adrenogonist • Anti inflammatory activity. • Activates adenyl cyclase • Inhibits the release of mucus • ATP to cyclic AMP • Reduce swelling • Relaxation of bronchial • Breathing Easier muscles • Breathing easier Improving Health and Quality of Life Do More, Feel Better, Live Longer
  20. 20. Advair Diskus Vs Its individual components Improving Health and Quality of Life Do More, Feel Better, Live Longer
  21. 21. Composition of Advair diskus • Disposible purple device 60 blisters Composition • Advair Diskus 100/50 • Advair Diskus 250/50 • Advair Diskus 500/50 Improving Health and Quality of Life Do More, Feel Better, Live Longer
  22. 22. How to use Advair Diskus Improving Health and Quality of Life Do More, Feel Better, Live Longer
  23. 23. Improving Health and Quality of Life Do More, Feel Better, Live Longer Marketing and Commercialization Ruchi Shah, CCO
  24. 24. Strategy • Well-positioned to peers. • Broad-based, geographically-diverse and well-balanced business. • Improved pipeline productivity. • Reduce expenditure, work closely with customers. • Use opportunities in the growing healthcare economies. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  25. 25. Our Products • Prescription medicines: Treatments for asthma, HIV/AIDS, malaria, depression, migraine, diabetes, hea rt failure, digestive conditions and cancer. • Vaccines: Over 25 vaccines to protect against illnesses such as hepatitis A and B, diphtheria, tetanus, whooping cough, typhoid and influenza. • Consumer healthcare: Dental health products, over-the-counter medicines and nutritional drinks. Ex. Panadol, Aquafresh, and Lucozade. Improving Health and Quality of Life Do More, Feel Better, Live Longer
  26. 26. Our top selling products in 2007 Product Turnover Seretide/Advair 3.5 £b Vaccines 2.0 £b Valtrex 934 £m Lucozade 347 £m Requip 346 £m Aquafresh 308 £m Sensodyne 293 £m Panadol 262 £m Horlicks 174 £m Improving Health and Quality of Life Do More, Feel Better, Live Longer
  27. 27. Products of Companies in Phases of Development Improving Health and Quality of Life Do More, Feel Better, Live Longer
  28. 28. Intellectual Property Improving Health and Quality of Life Do More, Feel Better, Live Longer
  29. 29. Trademark & In-licensing Improving Health and Quality of Life Do More, Feel Better, Live Longer
  30. 30. Competitors Diagnose GSK’s Product Competitor and Its Product CNS Disorders Paxil Prozac (Eli Lilly) Zoloft (Pfizer) Celexa(Forest GSK AZN MRK Laboratories) Imigran Maxalt (Merck) Advair Symbicort Singulair Respiratory Advair Singular (Merck) Serevent Symbicort (AstraZeneca) $ 6.9 billion $1.6 Billion (2007 $4.3 billion Flixotide Spriva(Pfizer) launched) Anti-bacterials Augmentin Zithromax (Pfizer) long-acting beta long-acting beta leukotriene Amoxil Cipro (Bayer) antagonist antagonist receptor Levaquin (J&J) antagonist Anti-malarials Malarone 4 years old and up 4 years old and up use in children Anti-viral Retrovir Famvir (Novartis) Relatively slow slightly faster cannot be used to Epivir Aciclovir action then Advair treat acute asthma Combivir Ziagen attacks Agenerase Effective Effective less effective than Trizivir ICSs Valtrex Zovirax Vaccines Angerix-B Comvax(Merck) Havrix Recombivax HB Improving Health and Quality of Life Do More, Feel Better, Live Longer
  31. 31. SWOT Analysis Strengths Weaknesses Strong sales growth forecast from launch portfolio in the An aging portfolio of products heavily exposed to 2006-2012 period generic competition Extensive early to mid stage R&D pipeline driven by High dependence on respiratory and CNS therapy CEDD markets (low growth) Vast sales and marketing force through mergers Failure to diversify and strengthen product portfolio and Strong capability, leadership and experience in lack of novel product launches since 2002 pharmaceutical management strategies Impact of safety issues relating to Avandia Positive Cash Reserves Recently expired patents Opportunities Threats CEDD’s potential to deliver strong sales growth in the Anticipated high exposure to generic competition over future as demonstrated by launch portfolio forecast the 2006-2012 period Product launches such as Tykerb and Cervarix (high Forecast negative sales growth performance over the growth oncology market) 2006-2012 could drive leadership to change business Recent Cost cutting initiatives model Strong forecast sales growth from vaccine products in Strong competition over the next four years the 2006-2012 period could support performance of non- Large scale M&A activity vaccine pharma products Improving Health and Quality of Life Do More, Feel Better, Live Longer
  32. 32. Improving Health and Quality of Life Do More, Feel Better, Live Longer Financials Elilas Sobrino, CFO
  33. 33. Income Statement Improving Health and Quality of Life Do More, Feel Better, Live Longer
  34. 34. Balance Sheet
  35. 35. Cash Flow Improving Health and Quality of Life Do More, Feel Better, Live Longer
  36. 36. Key facts • Every second... we distribute more than 35 doses of vaccine • Every minute... more than 1,100 prescriptions are written for GSK products • Every hour... we spend more than £300,000 (US$562,000) to find new medicines • Every day... more than 200 million people around the world use a GSK brand toothbrush or toothpaste • Every year... our factories produce 9 billion Tums tablets, 6 billion Panadol tablets and 600 million tubes of toothpaste Improving Health and Quality of Life Do More, Feel Better, Live Longer

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