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Joint Programming as a response to
          societal challenges



Joint Programming Initiative on Neurodegenerative
Diseases:
The Next Challenges

                                               Prof. Philippe Amouyel
                                      Chair, JPND Management Board
Alzheimer’s and Neurodegenerative
Diseases in Europe
                        Alzheimer’s    Number of cases   Societal costs (€)

                              2010           6,000,000    72,000,000,000
                              2040          12,000,000   144,000,000,000




                                      A major societal
                                      challenge for the
                                       coming years
The JPND goals
  To tackle the challenge of Alzheimer’s and other neurodegenerative diseases*,
  the goals of the JPND Research Strategy are:

  •   To develop new treatments and preventive strategies

  •   To improve health and social care approaches

  •   To raise awareness and de-stigmatise neurodegenerative disorders

  •   To alleviate the economic and social burden of these diseases

* Alzheimer’s disease and other dementias (AD), Parkinson’s disease (PD) and PD-related
disorders, Prion disease, motor neurone diseases (MND), Huntington’s disease (HD),
spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA)
JPND Mapping 2011




from www.jpnd.eu
JPND - Clearing Steps
•   The Foundations

    •   Agree on a Common Vision
    •   Build Trust
    •   Define Terms of Reference
    •   Structure the Governance
    •   Working Together
•   The Strategic Research Agenda
•   The Implementation
•   Towards Sustainability
Governance
                    27 countries

                    Management
                      Board

                     Executive           Scientific
                      Board              Advisory
                                          Board
                     Jumpahead
                      Steering
                     Committee

             WP1   WP2   WP3       WP4   WP5
JPND Research Strategy (SRA)
•   What is it?
    • A holistic ‘roadmap’ for future EU-wide activity and investment
        •   Not a review of the field, not a list of calls for proposals
    •   Launched Feb 7th, 2012
    •   5 research priorities, 9 enabling activities

•   Delivery has taken into account
    • SAB recommendations
        • Outputs from 4 scientific/strategic workshops
    • National and European portfolios
        • Mapping exercise of National and European programmes
    • Broad consultation with stakeholder groups
        • Both Online and Offline
A European Challenge

“The answers to these challenges will be found in science and research.
This Research Strategy comes not a moment too soon. It provides a
much-needed framework for European-level coordination and investment
in neurodegenerative disease research.”




Mrs Máire Geoghegan-Quinn European
Commissioner for Research, Innovation and Science
Launch of the Research Strategy of JPND
Brussels, 7 February 2012
Next Steps

•   The JPI must have clear and quantifiable scientific objectives to propose
    •   The SRA alone is not sufficient
    •   It is only a holistic roadmap
    •   An implementation plan is compulsory


•   Objectives must be in-line with the scientific strategy of each country
    •   Some countries have their own National Plan
    •   Others need to build one
The Implementation Plan

•   Create list of priorities from JPND Research Strategy proposals
•   Organise thematic working groups
•   Create list of opportunities suited for implementation
•   Organise specific task forces
•   Stimulate and align National Plans
•   Set action groups for specific priorities and encouraging collaborations
•   Support implementation
Some achievements
•   Creation of stable management structure with efficient procedures
•   Mapping exercise and associated public database
•   JPND Joint Transnational Calls:
    •   One in 2011 for €15M ; Two in 2012-2013 for €25M

•   Centres of Excellence in Neurodegeneration program:
    •   2011 for €6M ; in 2012-13 for €8M

•   Opening up to Third Countries:
    •   Canada already, on-going discussions with US
The next Challenges


•   To implement over time

•   To partner with EU

•   To partner with industry

•   To ensure JPND sustainability
To implement over time
•   Developing attractive programs

•   Easier when a National Plan already exists

•   Always « a la carte »

•   Need for synchronisation of funding decisions in each country (yearly basis)

•   Strengthing decisions by signing Memorandum of Understanding

•   Importance of phasing and overlap

•   Diversity of the tools
To partner with EU
•   Establish a programme of co-investment

•   Work towards a sustained increased of the investment amongst JPND partners

•   Leverage the value of investments and resources at both national and European
    Commission level, to the benefit of Europe

    Examples:
    •Synergy between JPND actions and H2020 programme
    •Linking national plans through actions engaging national infrastructures
    •Development and long term sustainability of European cohorts
    •Unlocking national capability on fellowship program
To partner with Industry
•   Participation in the Research Strategy delivery

•   Enlarge the contacts (pharma, device, IT, diagnosis, imaging, welfare
    technologies, AAL, …)

•   Ongoing discussions with IMI

•   Not a single mechanism to interact for companies
    • access to infrastructures and clinical networks
    • associate in JPND calls
    • set up an educational program
To ensure JPND sustainability
•   JPND is supported by the CA Jumpahead

•   Improve / achieve efficiency

•   Provide points of influence of key stakeholders

•   Inclusive of member states interest

•   Permanent full time senior management resources

•   Cash / in-kind contributions from member states

•   Legal structure
Joining forces
to fight neurodegenerative diseases


‘We hope that JPND will be a successful pilot for research into
other challenges, as well as lead to a reduction in the burden of
neurodegenerative diseases.’




www.thelancet.com/neurology Vol 12 February 2013, Editorial p119
Keep up to date
•   Visit the JPND website:
    • http://www.neurodegenerationresearch.eu
    • http://www.jpnd.eu

•   Search our Mapping Database

•   Sign up to the JPND News Feeds

•   E-mail us: secretariat@jpnd.eu


•   Follow us on Twitter: @JPNDEurope

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JPI Conference Dublin Plenary Session Philippe Amouyel

  • 1. Joint Programming as a response to societal challenges Joint Programming Initiative on Neurodegenerative Diseases: The Next Challenges Prof. Philippe Amouyel Chair, JPND Management Board
  • 2. Alzheimer’s and Neurodegenerative Diseases in Europe Alzheimer’s Number of cases Societal costs (€) 2010 6,000,000 72,000,000,000 2040 12,000,000 144,000,000,000 A major societal challenge for the coming years
  • 3. The JPND goals To tackle the challenge of Alzheimer’s and other neurodegenerative diseases*, the goals of the JPND Research Strategy are: • To develop new treatments and preventive strategies • To improve health and social care approaches • To raise awareness and de-stigmatise neurodegenerative disorders • To alleviate the economic and social burden of these diseases * Alzheimer’s disease and other dementias (AD), Parkinson’s disease (PD) and PD-related disorders, Prion disease, motor neurone diseases (MND), Huntington’s disease (HD), spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA)
  • 5. JPND - Clearing Steps • The Foundations • Agree on a Common Vision • Build Trust • Define Terms of Reference • Structure the Governance • Working Together • The Strategic Research Agenda • The Implementation • Towards Sustainability
  • 6. Governance 27 countries Management Board Executive Scientific Board Advisory Board Jumpahead Steering Committee WP1 WP2 WP3 WP4 WP5
  • 7. JPND Research Strategy (SRA) • What is it? • A holistic ‘roadmap’ for future EU-wide activity and investment • Not a review of the field, not a list of calls for proposals • Launched Feb 7th, 2012 • 5 research priorities, 9 enabling activities • Delivery has taken into account • SAB recommendations • Outputs from 4 scientific/strategic workshops • National and European portfolios • Mapping exercise of National and European programmes • Broad consultation with stakeholder groups • Both Online and Offline
  • 8. A European Challenge “The answers to these challenges will be found in science and research. This Research Strategy comes not a moment too soon. It provides a much-needed framework for European-level coordination and investment in neurodegenerative disease research.” Mrs Máire Geoghegan-Quinn European Commissioner for Research, Innovation and Science Launch of the Research Strategy of JPND Brussels, 7 February 2012
  • 9. Next Steps • The JPI must have clear and quantifiable scientific objectives to propose • The SRA alone is not sufficient • It is only a holistic roadmap • An implementation plan is compulsory • Objectives must be in-line with the scientific strategy of each country • Some countries have their own National Plan • Others need to build one
  • 10. The Implementation Plan • Create list of priorities from JPND Research Strategy proposals • Organise thematic working groups • Create list of opportunities suited for implementation • Organise specific task forces • Stimulate and align National Plans • Set action groups for specific priorities and encouraging collaborations • Support implementation
  • 11. Some achievements • Creation of stable management structure with efficient procedures • Mapping exercise and associated public database • JPND Joint Transnational Calls: • One in 2011 for €15M ; Two in 2012-2013 for €25M • Centres of Excellence in Neurodegeneration program: • 2011 for €6M ; in 2012-13 for €8M • Opening up to Third Countries: • Canada already, on-going discussions with US
  • 12. The next Challenges • To implement over time • To partner with EU • To partner with industry • To ensure JPND sustainability
  • 13. To implement over time • Developing attractive programs • Easier when a National Plan already exists • Always « a la carte » • Need for synchronisation of funding decisions in each country (yearly basis) • Strengthing decisions by signing Memorandum of Understanding • Importance of phasing and overlap • Diversity of the tools
  • 14. To partner with EU • Establish a programme of co-investment • Work towards a sustained increased of the investment amongst JPND partners • Leverage the value of investments and resources at both national and European Commission level, to the benefit of Europe Examples: •Synergy between JPND actions and H2020 programme •Linking national plans through actions engaging national infrastructures •Development and long term sustainability of European cohorts •Unlocking national capability on fellowship program
  • 15. To partner with Industry • Participation in the Research Strategy delivery • Enlarge the contacts (pharma, device, IT, diagnosis, imaging, welfare technologies, AAL, …) • Ongoing discussions with IMI • Not a single mechanism to interact for companies • access to infrastructures and clinical networks • associate in JPND calls • set up an educational program
  • 16. To ensure JPND sustainability • JPND is supported by the CA Jumpahead • Improve / achieve efficiency • Provide points of influence of key stakeholders • Inclusive of member states interest • Permanent full time senior management resources • Cash / in-kind contributions from member states • Legal structure
  • 17. Joining forces to fight neurodegenerative diseases ‘We hope that JPND will be a successful pilot for research into other challenges, as well as lead to a reduction in the burden of neurodegenerative diseases.’ www.thelancet.com/neurology Vol 12 February 2013, Editorial p119
  • 18. Keep up to date • Visit the JPND website: • http://www.neurodegenerationresearch.eu • http://www.jpnd.eu • Search our Mapping Database • Sign up to the JPND News Feeds • E-mail us: secretariat@jpnd.eu • Follow us on Twitter: @JPNDEurope