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Joint Programming in Neurodegenerative Disease Research (JPND) Coordinating approaches to research across Europe 
Derick Mitchell 
Dublin 
12/12/2014
Joint Programming in Research? 
•Countriesworking together to: 
•Identify core research questions (or the next societal challenge) 
•Define, develop and implement a common research agenda 
•Avoid duplication, synergize on common research themes 
•Implementation through voluntary, a-la-carte activities 
Close to 85% of public research funds in the EU 
are spent independently by Member States
We cannot tackle neurodegenerative diseases by acting as single countries 
Albania 
Austria 
Belgium 
Canada 
Croatia 
Czech Republic 
Denmark 
Finland 
France 
Germany 
Greece 
Hungary 
Ireland 
Israel 
Italy 
Luxembourg 
Netherlands 
Norway 
Poland 
Portugal 
Romania 
Slovakia 
Slovenia 
Spain 
Sweden 
Switzerland 
Turkey 
United Kingdom 
JPND is the largest global ND research initiative 
led by EU countries, with 28 participating 
EU member states 
Associated countries 
Third countries 
Increasing coordination of national research programmes to improve impact and effectiveness
Scope of JPND Research 
Scientific 
Medical 
Social
JPND brings together 
•Researchers (Basic, Clinical, Healthcare/Social) 
•National Funding Bodies 
•National Research Strategies and Investments
Goals 
To tackle the challenge of Alzheimer’s and other neurodegenerative diseases, the goals of the JPND Research Strategy are: 
•To develop new treatments and preventive strategies 
•To improve health and social care approaches 
•To raise awareness and de-stigmatise neurodegenerative disorders 
•To alleviate the economic and social burden of these diseases
Neurodegenerative Diseases? 
•The neurodegenerative diseases that JPND focuses on are: 
•Alzheimer’s disease and other dementias 
•Parkinson’s disease and related disorders 
•Prion disease 
•Motor neurone diseases 
•Huntington’s Disease 
•Spinocerebellarataxia (SCA) 
•Spinal muscular atrophy (SMA)
Defragmentation 
–what JPND is all about… 
STRATEGIC RESEARCH AGENDA 
ALIGNMENT OF EU COUNTRIES 
ON COMMON RESEARCH GOALS
JPND Research Strategy (SRA) 
•Agreed by all JPND Member States + Assoc. Countries 
•Officially Launched Feb 7th2012 
•Thematic priorities for future research: 
•The origins of neurodegenerative disease 
•Disease mechanisms and models 
•Disease definitions and diagnosis 
•Developing therapies, preventive strategies and interventions 
•Healthcare and social care
SRA Implementation (2012-2014) Annual Calls for Proposals 
Centresof Excellence in Neurodegeneration(CoEN) 
Year 
Total fund available 
Research Area 
No. of Projects 
2011 
(pilot) 
€16M 
Optimization of biomarkers 
+harmonization of their use 
4 
2012 
€18M 
Risk and Protective Factors 
5 
2012 
€11M 
Evaluation of Healthcare 
6 
2013 
€12M 
Cross-Disease Analysis 
10 
2013 
€11M 
Pilot Preventive Strategies 
5 
2011 
€6M 
Phase I : 
common resources and methodological approaches 
8 
2012-13 
€8M 
Phase II : “Pathfinder” projects 
5
Annual Call statistics 
Year 
Call area of interest 
No. of proposals submitted 
Budget requested (million €) 
No. of proposals recommended for funding 
No. of proposals supported 
Budget supported (million €) 
Success rate (%) 
2011 
Harmonization of Biomarkers 
14 
€31 
5 
4 
€14 
29% 
2012 
Risk and Protective Factors 
52 
€97 
18 
5 
€17 
10% 
2012 
Healthcare Evaluation 
22 
€29 
9 
6 
€9 
27% 
2013 
Cross-Disease Analysis 
90* 
€112 
23 
10 
€12.5 
11% 
2013 
Pilot Preventive Strategies 
35* 
€36 
5 
5 
€7 
14% 
Total 
213 
€157m 
60 
30 
€59.5m 
18% 
* pre-proposals
JPND-supported projects Risk and Protective Factors 
•APGeM: Pre-clinical genotype-phenotype predictors of Alzheimer’s disease and other dementias 
Coordinator: TormodFladby, AkershusUniversity Hospital, Norway 
•PERADES: Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease using multiple powerful cohorts, focussed Epigenetics and Stem cell metabolomics 
Coordinator: Julie Williams, Cardiff University, United Kingdom 
•RiMod-FTD: Risk and Modifying factors in Fronto-Temporal Dementia 
Coordinator: Peter Heutink, German Centerfor Neurodegenerative Diseases –Tübingen, Germany
JPND-supported projects: Cross Disease Analysis 
•DAMNDPATHS 
Elucidation of common transcriptional targets in vulnerable DopAmine, MotorNeuronand frontotemporalDementia disease PATHwayS. Coordinator: Eva Hedlund, Sweden 
•MissingLink 
Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogeniccascade: Ideal prevention / diagnostic / therapeutic targets in ND. Coordinator: Mariano Carrión-Vázquez, Spain 
•NeuroGeM 
Identification of genes that modulate the severity of all neurodegenerative diseases. Coordinator: JörgGsponer, Canada
JPND-supported projects: Pilot Preventive Strategies 
•EURO-SCD: Subjective cognitive decline in preclinical Alzheimer’s Disease: European initiative on harmonization and on a lifestyle-based prevention strategy Coordinator: Frank Jessen, Germany 
•MIND-AD: Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies Coordinator: Mia Kivipelto, Finland 
•NEUROEXERCISE: The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI). Coordinator: Stefan Schneider, Germany 
•PreFrontAls: Searching for therapeutic interventions in frontotemporaldementia with C9ORF72 repeat expansions in the presymptomaticstage. Coordinator: John C van Swieten, The Netherlands
Irish Researchers in JPND consortia 
Researcher 
Projects 
Fundedby 
Brian Lawlor 
Trinity College Dublin 
•BIOMARKAPD (Biomarkers) 
•NEUROEXEC (Preventive Strategy) 
HRB 
Orla Hardiman 
Trinity College Dublin 
•SOPHIA (Biomarkers) 
•ALS-CARE (HealthcareEvaluation)–Coordinator 
•STRENGTH (Risk Factors) 
HRB 
Kate Irving 
DublinCity University 
•ACTIF-CARE (Healthcare Evaluation) 
HRB 
Damien Thompson 
Universityof Limerick 
•MissingLink(Cross-Disease Analysis) 
SFI 
Jochen Prehn 
RoyalCollege of Surgeons, Ireland 
•CeBioN(Cross-Disease Analysis) 
SFI
JPND Partnering Tool
SRA Implementation (2012-2014) JPND Action Groups
Action Group Recommendations
“Rapid Action” Call for working groups
Coordination and development of best practice 
Ten JPND working groups to address methodological challenges for longitudinal cohort studies such as: 
•Cognition / Functional Assessment 
•Biomarkers 
•Biobanking 
•Imaging 
•Health and Social Outcomes 
•PresymptomaticND
2015 Call for proposals 
•January 2015 -CofundedCall with European Commission 
•Three topics 
•Longitudinal Cohort Approaches 
•Advanced Experimental Models 
•Risk/Protective Factors 
•€30 million from Member States 
•top-up of €10 million from European Commission
Keep up to date 
•Visit the JPND website: 
•http://www.jpnd.eu 
•Sign up to the JPND News Feeds 
•E-mailus: secretariat@jpnd.eu 
•Follow us on Twitter: 
@JPNDEurope

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Derick Mitchell CARDI Event December 2014

  • 1. Joint Programming in Neurodegenerative Disease Research (JPND) Coordinating approaches to research across Europe Derick Mitchell Dublin 12/12/2014
  • 2. Joint Programming in Research? •Countriesworking together to: •Identify core research questions (or the next societal challenge) •Define, develop and implement a common research agenda •Avoid duplication, synergize on common research themes •Implementation through voluntary, a-la-carte activities Close to 85% of public research funds in the EU are spent independently by Member States
  • 3. We cannot tackle neurodegenerative diseases by acting as single countries Albania Austria Belgium Canada Croatia Czech Republic Denmark Finland France Germany Greece Hungary Ireland Israel Italy Luxembourg Netherlands Norway Poland Portugal Romania Slovakia Slovenia Spain Sweden Switzerland Turkey United Kingdom JPND is the largest global ND research initiative led by EU countries, with 28 participating EU member states Associated countries Third countries Increasing coordination of national research programmes to improve impact and effectiveness
  • 4. Scope of JPND Research Scientific Medical Social
  • 5. JPND brings together •Researchers (Basic, Clinical, Healthcare/Social) •National Funding Bodies •National Research Strategies and Investments
  • 6. Goals To tackle the challenge of Alzheimer’s and other neurodegenerative diseases, the goals of the JPND Research Strategy are: •To develop new treatments and preventive strategies •To improve health and social care approaches •To raise awareness and de-stigmatise neurodegenerative disorders •To alleviate the economic and social burden of these diseases
  • 7. Neurodegenerative Diseases? •The neurodegenerative diseases that JPND focuses on are: •Alzheimer’s disease and other dementias •Parkinson’s disease and related disorders •Prion disease •Motor neurone diseases •Huntington’s Disease •Spinocerebellarataxia (SCA) •Spinal muscular atrophy (SMA)
  • 8. Defragmentation –what JPND is all about… STRATEGIC RESEARCH AGENDA ALIGNMENT OF EU COUNTRIES ON COMMON RESEARCH GOALS
  • 9. JPND Research Strategy (SRA) •Agreed by all JPND Member States + Assoc. Countries •Officially Launched Feb 7th2012 •Thematic priorities for future research: •The origins of neurodegenerative disease •Disease mechanisms and models •Disease definitions and diagnosis •Developing therapies, preventive strategies and interventions •Healthcare and social care
  • 10. SRA Implementation (2012-2014) Annual Calls for Proposals Centresof Excellence in Neurodegeneration(CoEN) Year Total fund available Research Area No. of Projects 2011 (pilot) €16M Optimization of biomarkers +harmonization of their use 4 2012 €18M Risk and Protective Factors 5 2012 €11M Evaluation of Healthcare 6 2013 €12M Cross-Disease Analysis 10 2013 €11M Pilot Preventive Strategies 5 2011 €6M Phase I : common resources and methodological approaches 8 2012-13 €8M Phase II : “Pathfinder” projects 5
  • 11. Annual Call statistics Year Call area of interest No. of proposals submitted Budget requested (million €) No. of proposals recommended for funding No. of proposals supported Budget supported (million €) Success rate (%) 2011 Harmonization of Biomarkers 14 €31 5 4 €14 29% 2012 Risk and Protective Factors 52 €97 18 5 €17 10% 2012 Healthcare Evaluation 22 €29 9 6 €9 27% 2013 Cross-Disease Analysis 90* €112 23 10 €12.5 11% 2013 Pilot Preventive Strategies 35* €36 5 5 €7 14% Total 213 €157m 60 30 €59.5m 18% * pre-proposals
  • 12. JPND-supported projects Risk and Protective Factors •APGeM: Pre-clinical genotype-phenotype predictors of Alzheimer’s disease and other dementias Coordinator: TormodFladby, AkershusUniversity Hospital, Norway •PERADES: Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease using multiple powerful cohorts, focussed Epigenetics and Stem cell metabolomics Coordinator: Julie Williams, Cardiff University, United Kingdom •RiMod-FTD: Risk and Modifying factors in Fronto-Temporal Dementia Coordinator: Peter Heutink, German Centerfor Neurodegenerative Diseases –Tübingen, Germany
  • 13. JPND-supported projects: Cross Disease Analysis •DAMNDPATHS Elucidation of common transcriptional targets in vulnerable DopAmine, MotorNeuronand frontotemporalDementia disease PATHwayS. Coordinator: Eva Hedlund, Sweden •MissingLink Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogeniccascade: Ideal prevention / diagnostic / therapeutic targets in ND. Coordinator: Mariano Carrión-Vázquez, Spain •NeuroGeM Identification of genes that modulate the severity of all neurodegenerative diseases. Coordinator: JörgGsponer, Canada
  • 14. JPND-supported projects: Pilot Preventive Strategies •EURO-SCD: Subjective cognitive decline in preclinical Alzheimer’s Disease: European initiative on harmonization and on a lifestyle-based prevention strategy Coordinator: Frank Jessen, Germany •MIND-AD: Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies Coordinator: Mia Kivipelto, Finland •NEUROEXERCISE: The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI). Coordinator: Stefan Schneider, Germany •PreFrontAls: Searching for therapeutic interventions in frontotemporaldementia with C9ORF72 repeat expansions in the presymptomaticstage. Coordinator: John C van Swieten, The Netherlands
  • 15. Irish Researchers in JPND consortia Researcher Projects Fundedby Brian Lawlor Trinity College Dublin •BIOMARKAPD (Biomarkers) •NEUROEXEC (Preventive Strategy) HRB Orla Hardiman Trinity College Dublin •SOPHIA (Biomarkers) •ALS-CARE (HealthcareEvaluation)–Coordinator •STRENGTH (Risk Factors) HRB Kate Irving DublinCity University •ACTIF-CARE (Healthcare Evaluation) HRB Damien Thompson Universityof Limerick •MissingLink(Cross-Disease Analysis) SFI Jochen Prehn RoyalCollege of Surgeons, Ireland •CeBioN(Cross-Disease Analysis) SFI
  • 17. SRA Implementation (2012-2014) JPND Action Groups
  • 19. “Rapid Action” Call for working groups
  • 20. Coordination and development of best practice Ten JPND working groups to address methodological challenges for longitudinal cohort studies such as: •Cognition / Functional Assessment •Biomarkers •Biobanking •Imaging •Health and Social Outcomes •PresymptomaticND
  • 21. 2015 Call for proposals •January 2015 -CofundedCall with European Commission •Three topics •Longitudinal Cohort Approaches •Advanced Experimental Models •Risk/Protective Factors •€30 million from Member States •top-up of €10 million from European Commission
  • 22. Keep up to date •Visit the JPND website: •http://www.jpnd.eu •Sign up to the JPND News Feeds •E-mailus: secretariat@jpnd.eu •Follow us on Twitter: @JPNDEurope