IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updates
1. www.guidetopharmacology.org
The IUPHAR/BPS Guide to PHARMACOLOGY in 2017:
new features and updates
Dr. Joanna Sharman
Wednesday 13th December 2017
Pharmacology 2017, London
http://www.guidetopharmacology.org
3. Data on human
drug targets and
potential targets
Recommended
experimental
ligands
Information on
approved drugs
Entry point into
pharmacological
literature
Sources of
further reading
Detailed
annotation for
important targets
Overviews of the
key properties of
target families
Target and
ligand
nomenclature
• GtoPdb is an open, expert curated pharmacology database
• Data are reviewed by an international network of >500 scientists in 96
subcommittees of the IUPHAR Nomenclature Committee (NC-IUPHAR)
4. A new portal linking GtoPdb targets and ligands to
immunological cell types, processes and diseases.
(Flash poster FP35 at 13:15 & poster PB128
Integrated Systems Pharmacology session at 14:45)
• Publication snapshot created from
the target family summary pages
• At-a-glance view of target properties
• Quick desktop reference guide
• Key ligands and further reading
• Links to GtoPdb
• Alexander SPH et al. (2017). Br J
Pharmacol. 174 (Suppl 1): S1-S446.
http://www.guidetopharmacology.org/concisehttp://www.guidetoimmunopharmacology.org
http://synpharm.guidetopharmacology.org
A tool for finding ligand binding sequences
which can be engineered into synthetic
proteins to confer drugability. Combines
pharmacological parameters from GtoPdb
with ligand binding data from the PDB.
A free learning resource to support education
and training in the pharmacological sciences
https://www.pharmacologyeducation.org
@PharmacologyEd
6. GtoPdb content - targets
~1,700 established/potential data-supported human drug targets
564 targets of marketed drugs (313 primary targets)
~1,100 additional related proteins
• G protein-coupled receptors (Class A, B, C, frizzled, adhesion and
orphan GPCRs)
• Ligand-gated, voltage-gated
and other ion channels
• Nuclear hormone receptors
• Catalytic receptors
• Enzymes including
kinases and proteases
• Transporters
• Other protein targets
6
Target numbers as of the 2017.6 release
7. ~9,000 ligands and drugs:
• Approved drugs
• Synthetic organic compounds
• Metabolites, hormones, neurotransmitters
• Natural products
• Endogenous and
other peptides
• Antibodies
• Inorganics
• Labelled ligands
GtoPdb content - ligands
Ligand numbers as of the 2017.6 release
11. GtoPdb home page
Home page
organisation
Quick links to target
and ligand classes
Updates about the
database
Latest news from our
blog, including hot
topics in pharmacology
Recent NC-IUPHAR
reviews
Links to other key
resources
14. Click for species-specific selectivity table
Ligand is endogenous in this species
Ligand is labelled
Ligand is radioactive
Approved drug
Primary target of this compound
Interaction tables
Immuno-relevant ligand
18. Ligand activity chart for palosuran showing species differences between human and rat
19. Organisation of ligand families
• New ligand family and group listing gives easy access to groups of ligands with
shared homology, functions or mechanism of action
20. Quick search box at the top of every page
with autocomplete for target, family and
ligand names
Advanced search for
targets/ligands
Download results as a CSV file
Sequence-based BLAST search for targets
Searching the database
22. Downloading data and files
• Generic slide set and poster for teaching (http://www.guidetopharmacology.org/slides.jsp)
• Target, ligand and interactions lists in CSV format, database dumps
(http://www.guidetopharmacology.org/download.jsp)
• RDF flat files of target-ligand interaction data for linked data browsing
(http://www.guidetopharmacology.org/download.jsp#rdf)
• REST web services for computational access to data
in JSON form (http://www.guidetopharmacology.org/webServices.jsp)
• Future: add customisable downloads, batch queries,
provide a linked-data browser and SPARQL query platform
TargetsLigands Interactions
23. • Nucleic Acids Research (Database Issue) article describing current status
Harding SD et al. (2018) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates
and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucl. Acids
Res. 46 (Database Issue): doi: 10.1093/nar/gkx1121.
• Current Protocols in Bioinformatics step-by-step protocols (in press)
Sharman JL et al. (2018) Accessing expert-curated pharmacological data in the
IUPHAR/BPS Guide to PHARMACOLOGY. Curr Protoc Bioinformatics.
• Help page (http://www.guidetopharmacology.org/helpPage.jsp)
• Tutorial (http://www.guidetopharmacology.org/GuidetoPHARMACOLOGY_Tutorial.pdf)
• Technical blog posts (http://blog.guidetopharmacology.org/)
• Follow us on
• Download slides and posters
• Email (enquiries@guidetopharmacology.org)
Find out more about GtoPdb
@GuidetoPHARM
24. Acknowledgements
• Database team:
• Jamie Davies (Principal Investigator)
• Joanna Sharman, Simon Harding (Developers)
• Adam Pawson, Elena Faccenda, Christopher Southan, Jane Armstrong (Curators)
• Toni Wigglesworth (Project Administrator)
• NC-IUPHAR members and subcommittees and Concise Guide to PHARMACOLOGY editors and contributors
• IUPHAR/BPS Guide to PHARMACOLOGY funders:
• All current and past NC-IUPHAR and website sponsors, especially:
Poster Session: Integrated Systems Pharmacology, Wed December 13th, 2:45 PM
PB128 - IUPHAR Guide to Immunopharmacology
PB135 - A systems pharmacology study of the cholesterol biosynthesis pathway
Poster Session: Education and Skills, Wed December 13th, 2:45 PM
PE004 - The International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification
(NC-IUPHAR): Relevance to pharmacology today and challenges for the future
PE005 - Navigating links between structures and papers: PubMed-to-PubChem connectivity from the Guide to PHARMACOLOGY
and the British Journal of Pharmacology
PE011 - The IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updates
Editor's Notes
The database is compiled by a team of curators and developers based in Edinburgh, and supported by the International Union of Basic and Clinical Pharmacology Nomenclature Committee with its 96 subcommittees comprising a network of over 500 scientists, who review the data and make recommendations.
We periodically review the set of databases we link to, and the current set is intentionally not comprehensive but it represents the resources that we believe have greatest utility for users. Many other resources are available via these links, in particular via UniProt.
These are some of the new tables added with immunopharmacology data. The disease information is currently being expanded, and new features will be available next year to browse a list of diseases with individual disease pages combining data on the targets and drugs relevant to that disease.
IMGT = the international ImMunoGeneTics information system