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IUPHAR Guide to IMMUNOPHARMACOLOGY

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Poster on GtoImmuPdb presented at European Congress of Immunology (Amsterdam, Sep 2018). Overview of the main data types and features included in this extension to the IUPHAR/BPS Guide to PHARMACOLOGY

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IUPHAR Guide to IMMUNOPHARMACOLOGY

  1. 1. GtoImmuPdb Data: Targets and Ligands The GtoP database has been enriched by tagging targets & ligands of immunological relevance and by linking these to immunological processes, cell types and relevant diseases. S. D. Harding1 , E. Faccenda1 , A. J. Pawson1 , J. L. Sharman1 , C. Southan1 , S. P. Alexander2 , S. Anderton3 , C. Bryant4 , A. P. Davenport5 , C. Doerig6 , D. Fabbro7 , F. Levi-Schaffer8 , M. Spedding9 , J. A. Davies1 1Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UNITED KINGDOM, 2Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM,3MRC Centre for Inflammation Research, QMRI, University of Edinburgh, Edinburgh, UNITED KINGDOM, 4 Veterinary Medicine, University of Cambridge, Cambridge, UNITED KINGDOM,5 Clinical Pharmacology Unit, University of Cambridge, Cambridge, UNITED KINGDOM, 6 Department of Microbiology, Monash University, Clayton, AUSTRALIA, 7PIQUR Therapeutics AG, Basel, SWITZERLAND, 8School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 9Spedding Research Solutions SARL, Le Vesinet, FRANCE. Introduction Immune/inflammatory/infection responses and disorders are a major focus of pharmacological R&D. Chronic diseases, aspects of ageing and progress of infection all have, or depend strongly on, an immune, or inflammatory, component. Being able to modulate these more effectively with better drugs would be immensely valuable. Development of these drugs will benefit from improved data exchange between the immunology expert and pharmacology expert communities. What is the Guide to IMMUNOPHARMACOLOGY Our Wellcome Trust-funded project to produce the IUPHAR Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb) addresses this need by providing a new portal to the existing IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb), that is both 'immunologist-friendly' for pharmacological information and 'pharmacologist-friendly' for accessing immunological agents and targets. GtoImmuPdb will be a freely-available, regularly updated and richly annotated resource. Curated by expert NC-IUPHAR* sub-committees, including additional contributors with expertise in immunity, inflammation and kinase biology. The 2018.3 GtoPdb release contain over 16,000 curated interactions across 2,875 human targets and 9,336 ligands. GtoImmuPdb Immunological Data Types www.guidetoimmunopharmacology.org Slideshare: http://ow.ly/AbSe30jVume Twitter: @GuidetoPHARM References * International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification 1. Harding SD, et al. (2018) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY. Nucl. Acids Res. 46(D1):D1091-D1106 PMID: 29149325 GtoImmuPdb presents a set of top-level immunological process and cell type categories against which targets in the database can be annotated and which form the basis of organising, navigating and searching for immunological process and cell type associations. Immuno Processes Antigen presentation Barrier integrity B cell (activation) Cellular signalling Chemotaxis & migration Cytokine production & signalling Immune regulation Immune system development Inflammation T cell (activation) Tissue repair Targets Ligands Cell types Processes Disease IUPHAR Guide to IMMUNOPHARMACOLOGY ● A unique access- point to immunological data in GtoPdb ● An expert-curated database containing immunological information ● Develop new pages and extend search mechanism for immunological data ● Assist in the identification of novel therapeutic targets ● Assist in identifying small-molecules for experimental investigation Detailed view pages display associations between targets and immunological data These include detailed curator comments and links to external references Displaying GtoImmuPdb data in detailed view of BTK As of 9 May 2017 GtoImmuPdb held 525 protein targets and 993 ligands tagged as being of immunological relevance. Ligand lists highlight immuno relevant ligands with new icons.Here showing inhibitors of BTK Disease summary pages highlight target and ligands relevant to immunological disease. Here, a snapshot of some ligands linked to Psoriasis – includes drug approval status, curatorial, clinical use and bio-activity comments GtoImmuPdb uses ontologies (Cell, Gene & Disease) as controlled vocabularies against which to annotate. Browse via immune system cell type for associated drug targets Showing snapshot of Enzyme targets asssociated with cytokine production & signalling. Includes GO annotations and curator comments

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