2. What is ithetis™
• ithetis™ is the world’s smallest
and most advanced implantable
drug delivery device (micro
IDDD)
• Characteristics
• Implantable from small rodents
(mice/rats) to larger animals
• Reduce labor work in laboratory
and improve performance
• Precise and versatile drug
dosing
• Wirelessly controlled
reprogrammable on the fly
(during animal experiments)
5. ithetis™ specs
• Reservoir: 1 ml
• Fully biocompatible, long-term
implantable encapsulation
• Telemetry module compliant
with EU & US radio regulations
• Programmable drug infusion
profile
• Bolus, periodic or continuous
flow drug administration
• Dimension L x W x H
42x16x7/11mm
6. ithetis™ application
• ithetis™ is intended to serve the basic preclinical research
market and to be used as drug delivery vehicle for studies in
small animals (mice, rats, rabbits) or other lab animals
• ithetis™ is wirelessly-controlled allowing full control of pump
drug delivery profile and pump performance during the entire
animal experiment
• ithetis™ is ideal for animal experiments were human
intervention (i.e., injection) must be minimized (behavioral
studies, etc.)
7. ithetis™ wireless technology
• ithetis™ wireless technology allows
bidirectional communication with a
large number of implanted devices
• Implants can be programmed and
checked wirelessly even during the
animal experiment
n: unlimited
8. ithetis™ application
• ithetis™ versatile programming
allows for continuous drug
administration at different
dosage levels
• ithetis™ can be programmed for
periodic drug release or
administration of boluses at
specified times
• ithetis™ allows combined
continuous and bolus
administration to match any
desired drug dosing profile
10. ithetis™ - Features
• Implantable in very small animals. The only programmable pump
implantable in small mice
• High precision volumetric pump technology
• Most versatile drug dosing profile. The only pump in the world that can
deliver
• Continuous steady flow
• Periodic drug infusion
• Boluses at prescribed times
• Combination of the above
• Two way communication. Allows programming on the fly and checking
pump performance during experiments
11. Why using ithetis™ - Benefits
• Round the clock programmed delivery of test material
• Ultra precise versatile administration of test material/drug
• Refined preclinical study protocols
• Convenient method for chronic dosing to laboratory animals
• Ensure reproducible precise results
• Eliminate nighttime and week-end dosing
• Eliminate stress and reduce to minimum handling of laboratory
animals
• Small size to use even in small mice
• Catheter allows targeted placement even in sensitive areas
(brain)
• Reduce drastically research costs
