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20. September 2011




MediSapiens Oy
Scientific possibilities of IST database




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Stratify your patients with
  thousands of others
Hundreds of patients




                                                                              High


                                                                              Medium   Resistant for therapy?

                                                                                       Worst prognosis?
                                                                              Low

                                                                                       Best prognosis?

                       Genomic signature for chromosomal instability



   Data from
   your patiens?

   Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
New therapy target for Ewing’s sarcoma?




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Novel breast cancer associated gene




Only three publications in PubMed
(none brca associated)
Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
High ectopic expression
in variety of cancers




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Key EMT regulator and
miRNA target in Brca




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Nearly unknown MMP related gene




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Known cell cycle player – new target
for Burkitt’s lymphoma therapy?




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Significant subsets of patients in multiple cancers
for a known phosphatase downstream of KRAS




Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
Are you sure your model actually
models the cancer you study?
                                                                                     Here we see three
                                                                                     commonly used
                                                                                     melanoma cell lines,
                                                                                     and how their gene
                                                                                     expression matches
                                                                                     actual in vivo samples,
                                                                                     with regards to
                                                                                     melanoma specific
                                                                                     genes.

                                                                                     We have a patent
                                                                                     pending algorithm*
                                                                                     that enables you to
                                                                                     compare your samples
                                                                                     with over 15 000 fully
                                                                                     annotated cancer
* Kilpinen et al. BioData Mining 2011, 4:5 Ojala et. al. Genome Medicine, In Press   samples.



Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
IST Online


Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
MediSapiens Ltd.
                             Biomedicum Helsinki                      +358 50 363 1848
                             Tukholmankatu 8A                         contact@medisapiens.com
                             FIN-00290 Helsinki                       medisapiens.com




Copyright © 2011 MediSapiens Ltd. All rights reserved. • www.medisapiens.com

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Ist scientific possibilities_200911_web

  • 1.
  • 2. 20. September 2011 MediSapiens Oy Scientific possibilities of IST database Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 3. Stratify your patients with thousands of others Hundreds of patients High Medium Resistant for therapy? Worst prognosis? Low Best prognosis? Genomic signature for chromosomal instability Data from your patiens? Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 4. New therapy target for Ewing’s sarcoma? Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 5. Novel breast cancer associated gene Only three publications in PubMed (none brca associated) Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 6. High ectopic expression in variety of cancers Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 7. Key EMT regulator and miRNA target in Brca Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 8. Nearly unknown MMP related gene Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 9. Known cell cycle player – new target for Burkitt’s lymphoma therapy? Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 10. Significant subsets of patients in multiple cancers for a known phosphatase downstream of KRAS Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 11. Are you sure your model actually models the cancer you study? Here we see three commonly used melanoma cell lines, and how their gene expression matches actual in vivo samples, with regards to melanoma specific genes. We have a patent pending algorithm* that enables you to compare your samples with over 15 000 fully annotated cancer * Kilpinen et al. BioData Mining 2011, 4:5 Ojala et. al. Genome Medicine, In Press samples. Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 12. IST Online Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com
  • 13. MediSapiens Ltd. Biomedicum Helsinki +358 50 363 1848 Tukholmankatu 8A contact@medisapiens.com FIN-00290 Helsinki medisapiens.com Copyright © 2011 MediSapiens Ltd. All rights reserved. • www.medisapiens.com