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“IRON
DEFICIENCY
ANEMIA”
Pharmcotherapeutics-1
Presented by
M.Ashritha
20Z51T0010
pharm.d 2nd yr
.
INTRODUCTION
•Anemia is the condition in which there is
deficiency of Red blood cells or the Hemoglobin
in the blood resulting in pallor & weariness.
•Anemia is not a disease it is a clinical
Manifestation of diseases.
•Anemia can be temporary or long term
(chronic).
•WHO defined Anemia as Hb <13.0g/dl for
men&<12.0g/dl for women.For pregnant
women <11.0g/dl.
Iron deficiency Anemia
•IDA is the most common nutrition deficiency
in the world.This is the most common type of
Anemia cuased by shortage of iron in the
body.
•It is the condition in which blood lacks
adequate healthy red blood cells.
•Iron is a key part of RBC which helps in
producing enough Hb to carry oxygen.low
levels of iron may leave the person
tired&shortness of breath.
Gradings of Anemia
Clinical Manifestations
• Pallor
• Fatigue& weakness
• Palpitations
• Smooth tongue
• Tachycardia
• Dyspnea on exertion
• Brittlenails
• Spooning of nails or
kolionychia
• Chilosis
• Tingling & Numbness
• Missed Menstrual cycle
• Glossitis
Etiology
•Decrease in RBC production
•Low iron diet
•GI problems
•Blood loss
•Poor absorption of iron by the body
•Pregnancy
•Lactation
•Aspirin &NSAIDS use
•Peptic ulcer disease.
Pathophysiology
Diagnosis
•Complete Blood Count
•Hemoglobin measurement
•Peripheral blood smear
•Iron studies.
Patient
Profile
Form
PATIENT DEMOGRAPHICS:
PATIENT NAME: Mrs. ABC IP NO. : 21054035 UNIT:
General ward
AGE: 45 yrs GENDER: Female DOA: 05/10/21
DOD: 08/10/21
REASON FOR ADMISSION: C/O pedal edema since 1 week,
easy fatigability since 1 month
PRESENT H/O: Patient was apparently asymptomatic 1 week
ago then she developed pedal edema since 1 week.
PAST H/O: No H/O HTN/DM, melenal hemoptysis
SOCIAL HISTORY: No social history
OCCUPATION: Homemaker
PHYSICAL EXAMINATION:
Pallor: Positive
Malnutrition: No
Edema of feet: Yes
Icterus: No
Clubbing: No
VITALS:
BP: 130/80 mmHg
PR: 90bpm
TEMP: Normal
CVS: S1S2+
RS: Normal breath sounds
LAB INVESTIGATIONS:
Biochemistry report:
PARAMETERS 05/10/21
Blood urea 25
Serum creatinine (0.6-1.2 mg/dL) 0.7
Random plasma glucose (79-140
mg/dL)
133
AST (0-35 U/L) 34
ALT (4-36 U/L) 38
ALP (44-147 IU/L) 94
Total bilirubin (0.3-1.0mg/dL) 0.7
Direct bilirubin (0.1-0.3mg/dL) 0.1
Indirect bilirubin (0.2-0.8mg/dL) 0.6
Total protein (6.4-8.3) 6.8
Albumin (3.5-5.0 gm/dL) 3.9
Globulin (2.3-3.4 gm/dL) 2.9
A/G 1.3
COMPLETE BLOOD PICTURE:
Date 05/10/21 06/10/21
Hb : 11-16/5 g/dL - F
14.3-18 g/dL -M
6.3 7.8
RBC count: 3.8-4.8ml/ m3- F
4.5-6.5ml/m3 -M
4.04 4.4
PCV : 35-50 g% - -
WBC count: 4000-11000 cells/ m3
5700 6800
Platelet: 1.5-4.0 Lac/ m3
4.0 3.20
Neutrophils: 40-75% 60 58
Lymphocytes: 20-40% 30 36
Monocytes: 2-10% 02 02
Eosinophils: 1-6% 08 04
Basophils: 0-1% 0 0
ESR: <20mm 1st hr - -
Ferritin: 10 to 120 ng/mL - 573
TIBC: 240 to 450 mcg/dL - 7
Date 05/10/21
Colour Pale yellow
Appearance Clear
Reaction Acidic
Spf.Gravity 1.015
Sugar Nil
Epithelial cells 2-4
Pus cells 2-3
COMPLETE URINE EXAMINATION:
RADIOLOGY INVESTIGATIONS:
ECG: 05/10/21
PR: 142bpm
Normal sinus rhythm
Mild left axis deviation
Borderline normal ECG
PERIPHERAL SMEAR :
•Microcytic severe hypochromic with auropolar cytosis with few tear drop
cells
•Mild eosinophilia
•Platelet adequate
FINAL DIAGNOSIS
“IRON DEFICIENCY ANEMIA”
Day wise Assessment
Physician medication chart
DISCHARGE MEDICATIONS:
Soap Analysis
•Subjective :
•A 45yrs female patient was admitted in the female
ward on 05/02/22.with chief complaints of pedel
edema since 1week,easy fatigability since 1month.
•Patient was apparently asymptomatic 1week ago
then she developed pedal edema since 1 week.
•Patient has no history of HTN,DM,Melenal
hemoptysis &No social history.
Objective :
•Based on the Lab Investigations
deficiencies are seen in
•ALT (4 – 36U/L). 38
•Hb: 11 – 16/5 g/dL – F. 6.3
14.3 – 18 g/dL – M.
•Ferritin: 10 – 120ng/mL. 573
•TIBC : 240 – 450 mcg/dL. 7
Assessment :
•Based on subjective data it is confirmed
that patient was suffering from pedel
edema since 1week ,easy fatigability
since 1month.
•Based on objective data the changes in
ALT levels, decreased Hb levels ,
Increased Ferritin levels & deceased
TIBC levels conclude that patient was
suffering from Iron deficiency Anemia.
Diagnosed as
Iron deficiency
Anemia
Plan
Drug interactions
•Pantoprazole +Cyanocobalamine
•Pantoprazole decreases levels of Cyanocobalamin
by inhibition of GI absorption.
•Drug- Food Interactions
•Milk,other diary products& grapes ,corn, sorghum
which contain tannins should not be taken with
iron supplements.
Patient counseling
• Intake of lean red
meat,chicken,turkey,Eggs&cereals
which are best source of iron.
• Intake of more vit-C drinks&foods like
orange juice,Melon, Strawberry,Kiwi,
Broccoli,Tomatoes.
• Cooking in cast iron utensils.
• Intake of more vit B12,B9,C products
which are abundantly available from
spinach,lentils,wholegrains,dark leafy
vegetables, berries, pepper.
• Take more beetroot which is great
blood builder.
• Iron supplement may turn your stool
black so don’t panic.
• Take medications on time.
Reference
• MEDSCAPE
• 1mg.com
• Drug today
• https://www.mayoclinic.org/diseases-conditions/iron-
deficiency-anemia/symptoms-causes/syc-20355034
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48365
95/
'iron anemia.ppt exam case.pptx

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'iron anemia.ppt exam case.pptx

  • 2. INTRODUCTION •Anemia is the condition in which there is deficiency of Red blood cells or the Hemoglobin in the blood resulting in pallor & weariness. •Anemia is not a disease it is a clinical Manifestation of diseases. •Anemia can be temporary or long term (chronic). •WHO defined Anemia as Hb <13.0g/dl for men&<12.0g/dl for women.For pregnant women <11.0g/dl.
  • 3. Iron deficiency Anemia •IDA is the most common nutrition deficiency in the world.This is the most common type of Anemia cuased by shortage of iron in the body. •It is the condition in which blood lacks adequate healthy red blood cells. •Iron is a key part of RBC which helps in producing enough Hb to carry oxygen.low levels of iron may leave the person tired&shortness of breath.
  • 5. Clinical Manifestations • Pallor • Fatigue& weakness • Palpitations • Smooth tongue • Tachycardia • Dyspnea on exertion • Brittlenails • Spooning of nails or kolionychia • Chilosis • Tingling & Numbness • Missed Menstrual cycle • Glossitis
  • 6.
  • 7. Etiology •Decrease in RBC production •Low iron diet •GI problems •Blood loss •Poor absorption of iron by the body •Pregnancy •Lactation •Aspirin &NSAIDS use •Peptic ulcer disease.
  • 9.
  • 10.
  • 11. Diagnosis •Complete Blood Count •Hemoglobin measurement •Peripheral blood smear •Iron studies.
  • 13. PATIENT DEMOGRAPHICS: PATIENT NAME: Mrs. ABC IP NO. : 21054035 UNIT: General ward AGE: 45 yrs GENDER: Female DOA: 05/10/21 DOD: 08/10/21 REASON FOR ADMISSION: C/O pedal edema since 1 week, easy fatigability since 1 month PRESENT H/O: Patient was apparently asymptomatic 1 week ago then she developed pedal edema since 1 week. PAST H/O: No H/O HTN/DM, melenal hemoptysis SOCIAL HISTORY: No social history OCCUPATION: Homemaker
  • 14. PHYSICAL EXAMINATION: Pallor: Positive Malnutrition: No Edema of feet: Yes Icterus: No Clubbing: No VITALS: BP: 130/80 mmHg PR: 90bpm TEMP: Normal CVS: S1S2+ RS: Normal breath sounds
  • 15. LAB INVESTIGATIONS: Biochemistry report: PARAMETERS 05/10/21 Blood urea 25 Serum creatinine (0.6-1.2 mg/dL) 0.7 Random plasma glucose (79-140 mg/dL) 133 AST (0-35 U/L) 34 ALT (4-36 U/L) 38 ALP (44-147 IU/L) 94 Total bilirubin (0.3-1.0mg/dL) 0.7 Direct bilirubin (0.1-0.3mg/dL) 0.1 Indirect bilirubin (0.2-0.8mg/dL) 0.6 Total protein (6.4-8.3) 6.8 Albumin (3.5-5.0 gm/dL) 3.9 Globulin (2.3-3.4 gm/dL) 2.9 A/G 1.3
  • 16. COMPLETE BLOOD PICTURE: Date 05/10/21 06/10/21 Hb : 11-16/5 g/dL - F 14.3-18 g/dL -M 6.3 7.8 RBC count: 3.8-4.8ml/ m3- F 4.5-6.5ml/m3 -M 4.04 4.4 PCV : 35-50 g% - - WBC count: 4000-11000 cells/ m3 5700 6800 Platelet: 1.5-4.0 Lac/ m3 4.0 3.20 Neutrophils: 40-75% 60 58 Lymphocytes: 20-40% 30 36 Monocytes: 2-10% 02 02 Eosinophils: 1-6% 08 04 Basophils: 0-1% 0 0 ESR: <20mm 1st hr - - Ferritin: 10 to 120 ng/mL - 573 TIBC: 240 to 450 mcg/dL - 7
  • 17. Date 05/10/21 Colour Pale yellow Appearance Clear Reaction Acidic Spf.Gravity 1.015 Sugar Nil Epithelial cells 2-4 Pus cells 2-3 COMPLETE URINE EXAMINATION: RADIOLOGY INVESTIGATIONS: ECG: 05/10/21 PR: 142bpm Normal sinus rhythm Mild left axis deviation Borderline normal ECG PERIPHERAL SMEAR : •Microcytic severe hypochromic with auropolar cytosis with few tear drop cells •Mild eosinophilia •Platelet adequate
  • 20.
  • 23. Soap Analysis •Subjective : •A 45yrs female patient was admitted in the female ward on 05/02/22.with chief complaints of pedel edema since 1week,easy fatigability since 1month. •Patient was apparently asymptomatic 1week ago then she developed pedal edema since 1 week. •Patient has no history of HTN,DM,Melenal hemoptysis &No social history.
  • 24. Objective : •Based on the Lab Investigations deficiencies are seen in •ALT (4 – 36U/L). 38 •Hb: 11 – 16/5 g/dL – F. 6.3 14.3 – 18 g/dL – M. •Ferritin: 10 – 120ng/mL. 573 •TIBC : 240 – 450 mcg/dL. 7
  • 25. Assessment : •Based on subjective data it is confirmed that patient was suffering from pedel edema since 1week ,easy fatigability since 1month. •Based on objective data the changes in ALT levels, decreased Hb levels , Increased Ferritin levels & deceased TIBC levels conclude that patient was suffering from Iron deficiency Anemia.
  • 27. Plan
  • 28. Drug interactions •Pantoprazole +Cyanocobalamine •Pantoprazole decreases levels of Cyanocobalamin by inhibition of GI absorption. •Drug- Food Interactions •Milk,other diary products& grapes ,corn, sorghum which contain tannins should not be taken with iron supplements.
  • 29. Patient counseling • Intake of lean red meat,chicken,turkey,Eggs&cereals which are best source of iron. • Intake of more vit-C drinks&foods like orange juice,Melon, Strawberry,Kiwi, Broccoli,Tomatoes. • Cooking in cast iron utensils. • Intake of more vit B12,B9,C products which are abundantly available from spinach,lentils,wholegrains,dark leafy vegetables, berries, pepper. • Take more beetroot which is great blood builder. • Iron supplement may turn your stool black so don’t panic. • Take medications on time.
  • 30.
  • 31. Reference • MEDSCAPE • 1mg.com • Drug today • https://www.mayoclinic.org/diseases-conditions/iron- deficiency-anemia/symptoms-causes/syc-20355034 • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48365 95/