Interprofessional working is recognized as valuable in Nepalese hospitals but faces barriers. A study of 38 healthcare professionals from 3 hospitals found that while collaboration is understood, medical professionals dominate due to differences in roles, status, and education. Barriers to interprofessional working include a lack of training and protocols, professional silos, and poor communication. Improving interprofessional collaboration in Nepal requires strategies like additional education, supportive policies, strong clinical leadership, and fostering respect between professions.