Ion channels are pore-forming membrane proteins that create a gated, water-filled pore to help establish and control voltage potential across cell membranes through control of the active flow of ions between the intracellular and the extracellular environments. https://www.creative-biogene.com/Services/Drug-Discovery-Services/Ion-Channel-Screening-Assays.html

2. ion channel
Membranes, or phospholipid bilayers, which are electrical insulators,
build a hydrophobic, low dielectric barrier to hydrophilic and charged
molecules. Ion channels are a sort of membrane protein complexes.
Their function is to facilitate the diffusion of ions across biological
membranes. Ion channels provide a high conducting, hydrophilic
pathway across the hydrophobic interior of the membrane. Ion
channels act as gateways which allow ions to travel through them to
respond to multiple signal events. And they are approved to regulate a
wide variety of processes important to ionic homeostasis.

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