LAM PCR (Linear - amplification mediated PCR) is a technology which is used for identifying and characterizing unknown flanking DNA adjacent to known DNA of any origin. More specifically, LAM-PCR has been developed to localize viral vector integration sites (IS) within the host genome.

2. LAM PCR Service
The application of viral vectors in gene therapy is rapidly developing and
the therapeutic results are highly promising. However, actively and
passively integrating (viral) vectors may fail to deliver, or trigger severe
side effects by undirected or unintended integration into the genome of
the target cell. Thus, the analysis of vector integration sites in target
cells is extremely important to address both biological and safety issues.
Creative Biogene, as a leading biotechnology company in the world, has
extensive expertise and experience which are available to provide you
with customer LAM PCR service to analyze the viral vector
insertion/integration site.

3. Brief Introduction
LAM PCR (Linear - amplification mediated PCR) is a technology which is used
for identifying and characterizing unknown flanking DNA adjacent to known
DNA of any origin. More specifically, LAM-PCR has been developed to localize
viral vector integration sites (IS) within the host genome [1, 2]. Genetic
elements like retroviruses or transposons integrate their genome into the host
genome in a (semi-) random manner [3-6]. In many cases, it is decisive to know
exactly the position where these vectors integrated. With years of
development, Creative Biogene has set up mature assays for several vectors,
including lentiviral and most oncoviral vectors, sleeping beauty transposons,
and some AAV-related vectors, etc.. Creative Biogene’s goal is to provide you
with the most affordable, high-quality LAM PCR services to ensure your
satisfaction in a timely and professional manner.

5. Application
. Analysis of the viral vector integration sites in host genomes
. Localization of genetic elements and characterization of unknown
flanking DNA
. Elucidating biological and clinical issues

6. Features
. Multiarm LAM-PCR service – can detect of low copy number, multiple
unknown DNA insertion site
. High accuracy and sensitivity
. Competitive prices
. Fast turnaround time

7. Contact informationContact information
Provider: Creative BiogeneCreative Biogene
URL: https://www.creative-biogene.com/Services/LAM-PCR-https://www.creative-biogene.com/Services/LAM-PCR-
service.htmlservice.html
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA
Phone No. 1-631-619-7922