Othello is a tragedy by William Shakespeare set in 16th century Venice and Cyprus, focusing on themes of jealousy, betrayal, and love. The play's protagonist, Othello, is a noble Moor whose tragic flaw of jealousy leads to his downfall, manipulated by the antagonist, Iago. The characters include Othello, Desdemona, Iago, Cassio, and others who highlight the complexities of love, honor, and loyalty.