School nurses face several challenges when integrating electronic health record (EHR) software, including ensuring seamless integration with other school systems, accurately migrating paper records to digital formats, customizing the EHR to meet each school's unique needs, providing comprehensive training to utilize various EHR features, and maintaining compliance with student health privacy laws. Proper planning that involves stakeholders, selects reputable EHR vendors, allocates resources for training and support, and continuous evaluation can help school nurses to effectively integrate EHR software and improve healthcare delivery and outcomes for students.