This document outlines the learning objectives for a series of lectures on inflammation. It covers the definition of inflammation, the vascular and cellular events involved in the pathogenesis of acute inflammation, the different morphological patterns of inflammation, and the regulation, fate and complications of the inflammatory response. Chronic inflammation is also discussed, including the general features and pathogenesis of granulomatous inflammation. The roles of inflammatory mediators and the variation in inflammatory responses between hosts are addressed.

1. ILOs OF INFLAMMATION
1. Lecture 1: definition, causes and vascular phase of pathogenesis of
inflammation
1-. Define inflammation (p.116 H.M.)
2. List causes of inflammation (P116 H.M.)
3. Cite the nomenclature of inflammation (LECTURE)
4. Classify inflammation (P116 H.M.)
5. Describe the clinical picture of acute inflammation (local and systemic) (P116 H.M.)
6. Enumerate cardinal signs of acute inflammation (P116 H.M.)
7-describe the vascular events involved in pathogenesis of inflammation and correlate
with the cardinal signs (116-118 H.M)
2. Lecture 2: cellular events, phagocytosis and inflammatory
mediators
1- Describe the leukocyte cellular events in acute inflammation (119-120 H.M.)
2- Illustrate the steps of leukocyte cellular events (119-120 H.M.)
3- Define chemotaxis (120 H.M.)
4- Identify chemotactic agents(120 H.M.)
5- Define phagocytosis(120-121-122 H.M.)
6- Recognize its steps and causes of its failure(120-121-122 H.M.)
7- Discuss the role of cellular changes in the pathogenesis of acute inflammation
8- List the different classes of mediators(122-127 H.M.)
9- Describe their role in inflammation

2. 3. Lecture 3: regulation and morphologic types of inflammation
1-List the systemic effects of inflammation(133-134 H.M.)
2-Discuss the regulation of inflammation(127-128 H.M.)
3-Discuss factors responsible for the variation in inflammatory response(131-132 H.M.)
4-Identify the different morphologic patterns of non-suppurative inflammation(132 H.M.)
5-Illustrate the fate of the different morphologic patterns of non-suppurative
inflammation (LECTURE)
5-Define suupurative inflammation (LECTURE)
6-Classify suppurative inflammation (LECTURE)
4. Lecture 4: fate and complications of inflammation
1-Classify and list examples of diffuse suppurative inflammation (LECTURE)
2-Explain the fate of an abscess (LECTURE)
3-Predict and explain the fate of acute inflammation (LECTURE)
4-Interpret the possible complications of acute inflammation (LECTURE)
5-Define pyemia(133 H.M.)
6-Classify pyemia (133 H.M)
7-Outline the pathogenesis of pyemia (133 H,M,)
8-Describe the morphology of pyemic abscesses and septic infarcts (133 H.M.)
5. Lecture 5: definition, types and pathogenesis of chronic
inflammation
1-Summarize the beneficial and harmful effects of inflammation(LECTURE)
2-Define chronic inflammation and determine its causes (134 H.M.)
3-Identify the nature and origin of cells in acute and chronic inflammation (128-129-130
H.M.)

3. 4-Determine cells of chronic inflammation (135 H.M)
5-Describe components of chronic inflammation(135 H.M.)
6-Define granuloma( 135 H.M.)
7-Explain pathogenesis of granuloma (135-136 H.M.)
Detailed contents
Lecture 1: definition, causes and pathogenesis of inflammation
1-definition of inflammation
2-aim of inflammation
3-nomenclature of inflammation
4-Causes of inflammation
5-local signs of inflammation
6-types of inflammation:
a- acute inflammation
b- chronic inflammation
7-cells of inflammation

4. 8-pathogenesis of inflammation
a- vascular events
b- cellular events
9-hemodynamic changes
10-altered vascular permeability
a-endothelial contraction
b-mild endothelial injury
c-direct endothelial injury
11-compare exudate and transudate
12-correlate vascular events with cardinal signs
lecture 2: pathogenesis and mediators of inflammation
1-cellular events of inflammation
2-extravasation:
a-margination
b-rolling
c-adhesion
d-transmigration
3-chemotaxis
4-phagocytosis
a-recognition and attachment
b-engulfment
c-killing and degradation
d-leucocyte activation
5-mediators of inflammation
a-cell derived
b-plasma derived
Lecture 3 :factors affecting inflammatory response, morphology of inflammation
1-systemic effects of inflammation
2-regulation of inflammation

5. 3-factors determining variation in inflammatory response
a-factors related to the host
b-factors related to the organism
4-morphology of acute inflammation
a-suppurative inflammation
b-non suppurative inflammation
5-catarrhal inflammation
6-serous inflammation
7-serofibrinous inflammation
8-pseudomembranous inflammation
9-allergic inflammation
10-hemorrhagic inflammation
11-suppurative inflammation
a-pus
b-abscess
c-boil, stye
d-carbuncle
Lecture 4: fate and complications of inflammation
1-diffuse suppurative inflammation
a-phlegmonous inflammation
b-suppuration in a body cavity
c-empyema of the gall bladder
d-cellulitis
2-fate and complication of acute inflammation
3-resolution
4-scarring
5-complications of acute inflammation
a-turn to chronic

6. b-complications related to healing (adhesions, keloid, sinus, fistula, ulcer)
c-superadded suppuration
d-spread (direct-natural passage-lymphatics-blood)
6-blood spread
a-bactraemia
b-viremia
c-toxemia
d-septicemia
e-pyeamia
f-septic infarcts
lecture 5: chronic inflammation
1-beneficial and harmful effects of inflammation
2-definition and types of chronic inflammation
3-general features of chronic inflammation
4-granulomatous inflammation
5-contrast acute and chronic inflammation