Topic: Infarction Faculty: Pathology Course: BSc RDT - 2nd year - Infarcts - Types of infarcts - Pathogenesis - Morphology

1. Infarction
Dr. Salman Ansari
Dept. of Pathology
Kanachur Institute of Medical Sciences

2. Contents
● Infarction

3. INFARCTION

4. Infarction
-Definition: Necrosis(death) of tissue, due to ischemia
- Area affected is called an infarct
- Causes of infarction: same as causes of ischemia

6. Red infarct

7. Pale infarct

8. Pathogenesis
- Increased blood flow initially
- affected part becomes swollen
- Cloudy swelling, cell degeneration, and cell death later
- Necrotic tissue breaks down
- WBCs come to site
- RBCs break down, so infarct becomes pale
- Granulation tissue grows, and infarct is replaced by scar

10. Morphology
Gross:
- Infarcts of solid organs are wedge-shaped
- Infarcts due to block in arteries are pale
- Infarcts due to block in veins are red
- Both become pale later on

14. Microscopic features:
- Ischemic necrosis
- Hemorrhage, neutrophils present
- Infarct replaced by scar later on

15. References:
● Ramadas Nayak - Textbook of Pathology for Allied Health Sciences
● Harsh Mohan - Textbook of Pathology
Questions:
salman.s.ansari92@gmail.com