This document discusses telomeres, which are caps on chromosomes that shorten as cells divide, contributing to aging. It describes research showing that telomerase activators from plant extracts can lengthen telomeres, reversing cell damage and aging signs. Examples are given of studies on humans finding improved health and youthful biological age from telomerase-activating supplements. The document promotes several supplement products claimed to contain telomerase activators and other botanicals for anti-aging effects.
B1 Topic 1 - classification (part 1 of 2):
Edexcell GCSE Science -> Higher -> Core Science -> B1 -> Topic 1 -> Classification
1st in the B1 Topic 1 series
- Contains everything you need to know from the specification*
- Specially designed for triple and dual science GCSE
- A good teaching tool
- A good revision tool
- Compliments the CGP revision books
*From Edexcell GCSE Science from 2011 specification, suitable for 2014 & 2015 exams
Contains detailed notes and questions that may come up in the exams.
Please comment with your views or any questions that you may have.
B1 Topic 1 - classification (part 1 of 2):
Edexcell GCSE Science -> Higher -> Core Science -> B1 -> Topic 1 -> Classification
1st in the B1 Topic 1 series
- Contains everything you need to know from the specification*
- Specially designed for triple and dual science GCSE
- A good teaching tool
- A good revision tool
- Compliments the CGP revision books
*From Edexcell GCSE Science from 2011 specification, suitable for 2014 & 2015 exams
Contains detailed notes and questions that may come up in the exams.
Please comment with your views or any questions that you may have.
FINITI™ naturally enhances the enzyme (telomerase) needed to lengthen our short telomeres. This adds healthy life to our cells.
Thousands of studies show the connection between short telomere and the natural process of cellular aging.
Double Stem Cell a miracle Natural product is discovered by Mibelle Biochemistry Switzerland.
Its efficacy is proven by clinical trial. It generate & repair the stem cell of the body.Our body comprises of 220 stem cell & 100 trillion functional cell. Each & every cell of
the body live & keep healthy by taking 6 Phytochemicals.
Disease is deficiencyof any or all Plant chemicals.
Calcium needs everyday male 800 mg & female 1200 mg . Bone & teeth's main component is Calcium. Human nervous system & muscle movement are conducted by Calcium. So deficiency of calcium may causes the severe health problem.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
FINITI™ naturally enhances the enzyme (telomerase) needed to lengthen our short telomeres. This adds healthy life to our cells.
Thousands of studies show the connection between short telomere and the natural process of cellular aging.
Double Stem Cell a miracle Natural product is discovered by Mibelle Biochemistry Switzerland.
Its efficacy is proven by clinical trial. It generate & repair the stem cell of the body.Our body comprises of 220 stem cell & 100 trillion functional cell. Each & every cell of
the body live & keep healthy by taking 6 Phytochemicals.
Disease is deficiencyof any or all Plant chemicals.
Calcium needs everyday male 800 mg & female 1200 mg . Bone & teeth's main component is Calcium. Human nervous system & muscle movement are conducted by Calcium. So deficiency of calcium may causes the severe health problem.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. What are Telomeres?
Telomeres are found within the body’s cells,
they are caps of repetitive DNA at the end of
our Chromosones.
They are known as our ‘Body Clock’
Each time our cells
divide they lose some
of this cap. This is how
our cells degenerate/age
over time.
3. Telomerase Research
This Nobel Prize winning research (2009),
is readily available to us today, it clearly
indicates that taking a 100% natural, plant
based food supplement containing
Telomerase Activators will help people to
Have an Increased Lifespan.
Have an increased Health span.
There will be a Greater Quality of Life as the
body will not degenerate as a result of
damage to the cells (loss of Telomeres) over
time.
4. Telomerase Production
Telomerase is a naturally occurring enzyme that
causes Telomeres to lengthen.
A gene able to produce Telomerase is already
present in every cell in our bodies. This gene
can be switched on by substances known as
Telomerase Activators.
Turning on Telomerase and lengthening
Telomeres has been documented to cause ‘A
dramatic reversal in the signs and symptoms of
ageing’ Dr Ron DePinoh, Dana Faber Cancer Institute, Harvard.
5. Telomerase Activators
The discovery of Telomerase Activators is in
some ways similar to the discovery of
Penicillin.
The first antibiotics were in a category all of
their own and were able to help people health-
wise in a way that, up until then, had never
been possible.
Telomerase Activators are totally unique, and
operate in a manner that has never been
seen before, to help people in a way that has
not been possible previously.
6. Telomerase Activation
Recent discoveries with respect to Telomerase
Activation contradict some of our long held ‘core
beliefs’.
“All animals including humans, are born, grow up,
become adults, plateau for a while (usually during
the mid 20’s). Then go down hill with lots of body
parts and organs degenerating as they age, and
nothing much can change that progression.”
Recent discoveries have now proven that belief to
be incorrect.
Don’t forget that for a long time people believed the
world to be flat!
7. Telomerase Activation
Your cells cannot build all the way to the tips
when they are
replicating
They need a
Guardian Angel
to come in and
add the missing
brick. That’s what
the Telomerase
Activators in
Product B do for
you.
8. Product B Nutrients
Milk Thistle Extract
Horny Goat Weed
Grape Seed Extract
Tumeric Root Extract
Ashwagandha Root Extract
Bacopa Extract
N-acetas yl-L-cystiene
Pomegranate fruit extract
DL-alpha lipoic acid extract
Asian Ginseng root extract
Berteine rhizome extract
Bilberry fruit extract
Blueberry Fruit Extract
Red Raspberry Fruit Extract
Green, White and Black Tea Extracts
Acacia Bark Extract
Plantain Leaf Extract
L-glutathione
Velvet Bean Extract
Hawthorn Root and Fruit Extracts
Quercetin
Boswellia Fruit Extract
Maca Root Extract
Resveratrol
Harada Fruit Extract
Shilajit Extract
Chia Seed Extract
9. Proof of the Concept 1
A Scientific paper written by Dr Bill Andrews
referencing 55 different scientific articles on
Telomeres can be found at www.sierrasci.com
website.
In 1961 Dr Leonard Hayflick discovered that
there is a limit to the number of times a cell can
divide, division has been established as between
40 and 60 times. The Hayflick Limit can not be
changed by adding nutrients, or the absence of
toxins or the absence of stress.
In 1998 The use of Telomerase Activators within
the cells was found to be the only way that cells
were able to successfully divide past the Hayflick
Limit.
10. Proof of the Concept 2
Experiments carried out and published by Dr Ron
DePinho (of the Dana Faber Cancer Institute) while
working with a team of scientists from Harvard
University. On 28 November 2010 they published
in the peer-reviewed journal ‘Nature’ that there
was a “dramatic reversal in the signs and
symptoms of ageing” once the Telomeres in the
cells were activated.
Once cells were Telomerased, the cell damage
was repaired and the body began to regenerate,
‘aged tissues do have a point of return’.
11. Proof of the Concept 3
Dr Ed Park has been consuming a Nutraceutical
Telomerase Activator for 4 years.
At age 44years his cellular biological age, recorded
from blood tests, measuring the Telomeres was
documented as 9,000 units which was equivalent to the
level of a 3 year old. His cells had regenerated.
Within 28 days changes have been noted such as
puffy dull skin became softer, smoother, and more
elastic, eye pouches and facial wrinkles reduced.
Improved memory and mental accuity
Stronger immunity to illness
A general flood of energy, including greater sexual
potency.
Check YouTube search : drpark65 for further information
12. Product B
Contains 30 botanicals which work
synergistically to reduce oxidative
stress.
Harness the body’s natural capacity
to fight premature ageing.
Contains Nrf2 activators which bind
to a segment of our DNA called the
Antioxidant Response Element, this
triggers a gene which produces over
20 natural antioxidants within our
cells.
13. 30-Day Nutritional Cleansing
Program
• Replaces up to 56 meals over the 30
days
• Removes toxins from your body
• Supplies your body with essential
vitamins and minerals to maintain
optimal health
14. Pillars of Health Program
• Replaces up to 28 meals over the 30
days
• Removes toxins from your body
• Supplies your body with essential
vitamins and minerals to rejuvenate
your body from the inside
16. Body Balance Program
• Replaces up to 28 meals over the 30
days
• Removes toxins from your body
• Supplies your body with essential
vitamins and minerals
• Provides a healthy energy boost for
those days when you need it
17. Shake and Cleanse Pack
• Replaces up to 28 meals over the 30
days
• Gently removes toxins from your body
18. 9-Day Nutritional Cleanse
• Replaces up to 14 meals over 9 days
• Quickly removes toxins from your body
• Provides low calorie, healthy, appetite
suppressing snacks to assist you through
the program
19. Isa Lean Bars
• Replaces up to 10 meals
• Makes a great addition to your child’s
lunch box
20. Want More Energy
• Pack of 18
• Healthy, delicious orange flavoured
alternative to boost your energy levels.
Contains no artificial colours, no sugar, no
caffeine and no man-made chemicals
• Safe for competitive athletes, children and
the elderly
These caps are 15,000 units long when we are conceived, they are only 10,000 units long when we are born, they continue to shorten as our cells divide throughout our life. When they are down to 5,000 units long our cells can no longer divide and we die.
Dr Elizabeth Blackburn from Tasmania Her work has opened a new field of science, raising the prospects of such medical breakthroughs as interfering with cancerous cells. Professor Blackburn won with her long-time US collaborators Jack Szostak, who worked on the telomeres unique DNA sequence, and Carol Greider, who co-identified the telomeres.