Dr Ricky Fraser, Acute Oncology Fellow, South West Wales Cancer Centre Joanne Upton, Skin Cancer Advanced Nurse Practitioner, The Clatterbridge Cancer Centre

1. Immunotherapy
Workshop
Ricky Frazer, Claire Higham and
Joanne Upton

2. Learning Outcomes
• Understand the main toxicities associated
with Immunotherapy
• Improve knowledge of tools and guidelines
available for assessment of toxicities
• Awareness of the treatment options available
for managing toxicities

3. Overview of Immunotherapy

4. Immunotherapy Classes
Active Immunotherapies:
Cancer Vaccines
Cytokines
Mediators of T-cell
activation
Passive Immunotherapies:
Tumour-directed
monoclonal antibodies
Cell therapies

5. Checkpoint Inhibitors

6. Adverse Events

7. AE Incidence

8. AE Management
Mild
Monitor
Plan
Moderate
Review
Oral steroids
Investigate
Omit I-O
Severe
Admit
IV steroids
Investigate
Specialist input
Stop I-O

9. Your Turn
• 4 Scenarios with different toxicities (2 tables
working on each scenario)
• 4 questions to answer 1) Symptoms may
present with 2) How to grade toxicity (tools
provided) 3) Investigations 4) Management
• We will then ask tables to feedback
• Flip chart and pens provided for feedback

10. Summary
• Increasing use of immunotherapy in oncology
• Autoimmune toxicity profile
• Protocols very important for management of
toxicities
• Initial treatment steroids
• Role for other immunosuppressive agents
• Multidisciplinary working essential

11. Questions