This document discusses Zika virus and its impact on immunocompromised patients and organ/tissue donors and recipients. It notes that while Zika seems to have no increased severity in immunocompromised patients yet, similar flaviviruses like dengue and chikungunya generally do not either. However, West Nile virus, which has a different vector, can cause increased neuroinvasive disease in immunocompromised individuals. Guidelines have been issued to screen organ and tissue donors for Zika risk factors like recent travel or residence in endemic areas. While donor screening for Zika may result in fewer tissue donations, it is not expected to significantly impact organ donations at this time. The need for organ transplants continues to out