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Immunisation in a digital world:
Futures Workshop
Tuesday 26th June 2018
This event is kindly supported by Sanofi
#ImmuTech
Welcome and plan for the
workshop
David Sinclair
Director
ILC-UK
This event is kindly supported by Sanofi
#ImmuTech
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Welcome
David Sinclair, International Longevity
Centre – UK @ilcuk @sinclairda
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The specialist think tank on
the impact of longevity on
society, and what happens
next.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Our work on vaccination
Working with and speaking at IFA events; Event on Vaccination
and AMR; Immune Response Report; SAATI report; Spoken at
events in London, Brussels, San Francisco, Barcelona etc;
Spoken at Academic (e.g. ECCMID; IAGG) as well as policy (IFA).
Ran vaccine related events at our conference. Worked with UK
and European policy-makers; House of Lords dinners; Worked
with All Party Vaccination Group and ABPI Group in Parliament;
Event in European Parliament; Spoke to DH Vaccine officials in
Australia; Maintained and promoted website; participated in
Florence Geriatric conferences; articles in media (e.g. in the
Guardian). Media stories about our work on vaccination.
Mentioned adult vaccination on BBC Breakfast interview.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Welcome
10:00 Welcome/Plan for the workshop David Sinclair, Director, ILC-UK
Why is adult immunisation important and what do we need to do to increase uptake?
10:10 Speeches and Panel discussion
How might technology help break down the barriers to adult immunisation?
10:50 Speeches and Q&A
Putting ourselves in the shoes of someone who isn’t vaccinated
12:15 Workshop - Why don’t adults get vaccinated
12:35 Lunch
13:05 Plan for the afternoon
How can technology help? Futures Workshop
13:10 Playing Higher or lower, pt. I - Ideas for using
technology
All
13:25 Playing Higher or lower, pt. 2 - Barriers to using
technology
All
13:40 Playing higher or lower, pt. 3 - Policy and practical
solutions to using technology
All
13:55 Feedback “Why don’t adults get vaccinated?” and
“Higher and Lower”
All
Conclusion
14:30 Speeches and reactions
16:00 Close All
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
What do we want from you today
 Stand up; make coffee; swap groups if you want; tell us what
you think.
 An open mind! Have a look at the posters
– Your ideas of how technology can increase uptake of adult
immunisation
– Your views on the barriers to the use of technology to
increase uptake of adult vaccination
– Your views on the policy change needed
We will publish a final report in the autumn.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
David Sinclair
Director
International Longevity Centre - UK
Davidsinclair@ilcuk.org.uk
02073400440
Twitter: @ilcuk and @sinclairda
Why is adult immunisation
important and what do we need to
do to increase uptake?
This event is kindly supported by Sanofi
#ImmuTech
Elena Gentile MEP
Group of the Progressive Alliance of
Socialists and Democrats
Italy
This event is kindly supported by Sanofi
#ImmuTech
Dave Eaton
Policy and Public Affairs Manager
ILC-UK
This event is kindly supported by Sanofi
#ImmuTech
Daphne Holt
Chair
Coalition for Life-Course Immunisation
This event is kindly supported by Sanofi
#ImmuTech
Peggy Maguire
Director General
European Institute of Women’s Health
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
This event is kindly supported by Sanofi
#ImmuTech
Dr Isabel De La Mata Barranco
Principal Adviser for Health and Crisis
Management
DG Sante
This event is kindly supported by Sanofi
#ImmuTech
Q&A
This event is kindly supported by Sanofi
#ImmuTech
How might technology help break
down the barriers to adult
immunisation?
This event is kindly supported by Sanofi
#ImmuTech
How the UK used technology and data
to maximise uptake of vaccination
David Salisbury
Centre on Global Health Security
Chatham House
This event is kindly supported by Sanofi
#ImmuTech
Immunisation in a digital world.
Prof. David Salisbury CB
FRCP FRCPCH FFPH FMedSci
Centre on Global Health Security, Chatham House, London.
Immunisation
data
Process Coverage
Outcome
Sero-
surveillance
Disease
surveillance
Adverse
reactions
Immunisation Performance Indicators
Birth
registration
• Prompt
• Ubiquitous
Physician
registration
• Call / recall
• Rapid upload
Local/Regional
/
National
• Data analysis
• Performance
management
Immunisation coverage data
Influenza vaccination: data for
management
Influenza vaccine uptake for those aged 65 and over and 65 at risk from 2000 to
2001
through to 2017 to 2018 for England. WHO 2010 target is 75%.
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/710416/Seasonal_influenza_vaccine_uptake_in_GP_patients_winter_season_2017
_to_2018..pdf
Vaccine uptake in under 65s, by indication for vaccination and age, in 2010-2011
Begum, F. and R. Pebody, Seasonal influenza vaccine uptake amongst GP patient groups in England, Winter season 2010-11, 2011,
Department of Health.
Flu mortality by risk group
Source – HPA: Surveillance of influenza and other respiratory viruses in the UK 2010-2011
Universal
childhood
influenza
vaccination
Impact of vaccination in 2014–2015: summary
• Number needed to prevent by vaccinating children for the whole population impact
– 16 children vaccination will prevent 1 GP ILI consultation
– 317 children vaccination will prevent 1 influenza hospitalisation
– 2205 children vaccination will prevent 1 confirmed influenza ICU/HDU admission.
Primary school pilot areas versus non-pilot areas
39
Age group GP ILI consultations ED respiratory
attendance
Hospital admission ICU/HDU admission
5–10 years -94%
OR 0.06 (0.01 – 0.62)
ARD -247/100,000 popn
-74%
OR 0.26 (0.08 – 0.91)
ARD - 9%
-93%
OR 0.07 (0.01 – 0.55)
ARD -16/100,000 popn
-76%*
OR 0.24 (0.02 to 3.01)
ARD -2/100,000 popn
<5 years -92%*
OR 0.08 (0.01 – 1.02)
ARD -227/100,000 popn
-65%*
OR 0.35 (0.04 – 2.94)
ARD - 16%
-62%*
OR 0.38 (0.11 – 1.32)
ARD -31/100,000 popn
-61%*
OR 0.39 (0.06 to 2.55)
ARD -3/100,000 popn
>17 years -59%
OR 0.41 (0.19 – 0.86)
ARD -289/100,000 popn
-21%*
OR 0.79 (0.37 – 11.66)
ARD - 1%
-34%*
OR 0.66 (0.22 – 11.93)
ARD -14/100,000 popn
-46%*
OR 0.54 (0.25 to 1.16)
ARD -2/100,000 popn
‘bold %’ p<0.05; * Statistically non significant; (%), confidence interval; ARD, absolute risk difference; popn,
population
ED, emergency department, GP, general practitioner, ILI, influenza-like illness, ICU, intensive care unit, HDU, high dependency unit
ADAPTED from Pebody RG et al. Euro Surveill. 2015;20(39):pii=30029.
Immunisation – the intersection.
StrategyPolicy
Informatio
n Systems
Performance
Management
How Big Data can address hurdles
related to vaccination access &
coverage
Michael Greenberg, M.D., MPH
Vice President and Head, Global Medical Strategy
Sanofi Pasteur
This event is kindly supported by Sanofi
#ImmuTech
Addressing vaccination access &
coverage through Big Data
Sources: 1National Diabetes Statistics Report, 2014 (released June 10, 2014) http://www.diabetes.org/diabetes-basics/statistics/?loc=db-slabnav#sthash.GuDGFjln.dpuf. Accessed April 9, 2015 | 2Gregg EW et al. N Engl J Med 2014;370:1514-1523 | 3ational Institute of Diabetes and Kidney Diseases 2009 |
MICRO-VASCULAR
COMPLICATIONS
FOR ENDORSEMENT
Global Medical Strategy, Sanofi Pasteur
Michael Greenberg, MD, MPH
6 Million
48 Million
2 Billion
48
28
Volume
SCALE OF DATA
Variety
DIFFERENT
FORMS OF DATA
Veracity
UNCERTAINTY
OF DATA
Velocity
ANALYSIS OF
STREAMING DATA
Thousands of publications
Flu – 50 million
flu queries weekly
Daily behavior of >57 000
diabetic patients
VAXITREND –
Internal Market Researches
20 countries; 17 000 patients, 3000 HCPs
The
FOUR Vs
Daily Behavior information
Activity trackers
Daily searches
Graphs / Tables
Internet queries & posts
Publications
Lifestyle Trackers
Internal data controls
Data cleaning
GRADE Evaluation:
Evaluate the quality
of medical evidence
Methodological rigor
Why Big Data?
Why Flu & Diabetes?
45
We need deeper understanding to increase flu vaccine coverage
HOSPITALIZATIONMetabolic complication:
Decompensation,
ketoacidosis , deaths
Infection complication
Secondary infection
Influenza vaccination is
recommended (and
funded)
DEATHS
3-6x
6x
Why do people living with
Diabetes do not get vaccinated
(more)?
3-Step pilot experimentation approach
46
• Scientific data review - make sure we don’t
find what is already known
• Using natural language processing, machine
learning, deep learning
• Design methodology for understanding
patient behavioral phenotypes
• Run small scale real-world pilots
• Experience building a datamart that unites
google, sanofi and publicly available data
• Emphasis on country level implementation
1
2
3
28/06/2018 47
EVIDATION: THE METHODOLOGY
We conducted a retrospective study of
influenza-related outcomes (IRO) among
fully insured Type 2 diabetics from a
large US payer over a 1 year period
covering the 2016-17 influenza season.
We used bivariate analyses (54,656
diabetics, mean age 54.8 yr, s.d. = 10.2)
to compare IRO’s inferred from claims
data against IRO’s for 113,016 age and
gender matched non-diabetics.
Samson S, Lee W et al. D Using Claims and Consumer Wearable Devices Data to Quantify Influenza-Related
Outcomes among Type 2 Diabetes Patients—A Large Population Study [abstract]. ADA, Orlando, June 22, 2018.
28/06/2018 48
EVIDATION: THE RESULTS
28/06/2018 49
EVIDATION: THE RESULTS (2/2)
Within 2-weeks before and 4-
weeks after a medical claim for
influenza, diabetics with influenza
had more observed hyperglycemic
events than in a comparable non-
influenza period in the same year
(p<0.001),
28/06/2018 50
GOOGLE: METHODOLOGY
We used VaxiTrends, a proprietary dataset, to identify variables influencing vaccine uptake among adults in
the U.S., China, France, Mexico, and U.K. We combined the data with National Health Interview Survey
results from the CDC, which offer insights into health behaviors of Americans with diabetes.
This information was aggregated with
data from Google FluTrend, which
signals flu incidence, & Google Trends
Application Programming Interface,
which tracks search keyword popularity
by location & date in a de-identified
fashion.
Cluster analyses indicated factors most
positively & negatively associated with
acceptance & adherence
Liska, J, Gupta A et al. D Using Claims and Consumer Wearable Devices Data to Quantify Influenza-Related Outcomes among Type 2
Diabetes Patients—A Large Population Study [abstract]. ADA, Orlando, June 22, 2018.
GOOGLE: RESULTS
51
factors impacting flu vaccination vary by country for people living with diabetes
Orderedintermsofimportance
fromHighestinfluencertoLowest
Negative Factors
Positive Factors
28/06/2018 52
GOOGLE: RESULTS
Adherence Impact Calculator
Google created a country specific
dashboard for local users to identify
behavioral drivers of flu vaccination &
the most receptive subgroups to
design tailored interventions to
increase uptake
Access to the right data remains a barrier
53
Improved vaccine
coverage estimates at
finer level
Individual, physician, pharmacy,
workplace
…not about personal data but better
understanding
THANK YOU
WHAT do we aim at delivering and HOW?
55
… to generate end 2017 value from Medical to Business Operations
1) Augmented data value
2) Accelerated evidence generation
3) Simplicity and scale of insights
4) Actionable learnings for the business
5) Continuous insight and performance
observation
1) Vaxitrend survey data for 2015
comprising of 5 countries (France,
USA, UK, Mexico and China)
2) Combined with Google’s Trends and
Flu Trends
3) … and NHIS* datasets
3 DATA SOURCES 5 DELIVERABLES
*The National Health Interview Survey (NHIS) has monitored the health of the US nation since 1957. NHIS data on a broad range of
health topics are collected through personal household interviews.
November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
China7 Quick win segment over clinical inertia
56
Insight: This group can be easily activated by a targeted campaign
• High intent to vaccinate
despite having zero adherence
• Scared of catching flu
• Takes action to protect
themselves against flu
• Seeks information about
health issues
China7
FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS
November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
China7 àQuick win segment over clinical inertia
8
Insight: This group can be easily activated by a targeted campaign
• High intent to vaccinate
despite having zero adherence
• Scared of catching flu
• Takes action to protect
themselves against flu
• Seeks information about
health issues
China7
FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS
November 8
th
2017Flu & Diabetes – Google Pilot Advancement Status
US3 Effort intensive segment for Higher Adherence
57
Insight: This group living with Diabetes should not be prioritized
• No intent to Vaccinate
• Issue with Accessibility
• Not in favor of Vaccination
• Don’t take flu job in spite of
reminders
• Think that they will not be
vulnerable to flu.
US3
FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS
November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
Google Influenza Trends Offers Regional Granularity
58
In a single view adherence with respect to Geographical level.
Search trends for both positive and
negative terms are observed .
November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
KEY FACTORS IMPACTING FLU VACCINATION ADHERENCE…
59
… vary by country for people living with Diabetes
Orderedintermsofimportance
fromHighestinfluencertoLowest
Negative Factors
Positive Factors
Social Media and Immunisation
Philip Weiss
Chairman
ZN Consulting
This event is kindly supported by Sanofi
#ImmuTech
https://prezi.com/r2rpwzixz7uk/fakenews-tweets-and-healthcare-
brussels/
This event is kindly supported by Sanofi
#ImmuTech
Local views and information on the current
Italian communication & digital context
Prof Pier Luigi Lopalco
Department of Translational Research and New
Technologies in Medicine and Surgery,
University of Pisa
This event is kindly supported by Sanofi
#ImmuTech
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
LOCAL VIEWS AND INFORMATION ON THE
CURRENT ITALIAN COMMUNICATION &
DIGITAL CONTEXT
Pier Luigi Lopalco
26 June 2018, Brussels
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
2009, flu pandemic
64
5 rules to better fight flu
Pandemic flu is
a normal flu
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
65
November 2014
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
66
Lethal
injection
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Immunization coverage >64 yrs
67Data source: Ministry of Health
%
Pandemic vaccination campaign
“Fluad case”
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
68
Rimini’s Court: “Measles vaccine causes autism”
According to judges in Milan Court there is a link
between hexavalent vaccine and autism
March 2012
September 2014
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Italy, 2014
69
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Google’s thermometer
70
0
10
20
30
40
50
60
70
80
90
100
jan
10
mar
10
may
10
july
10
sept
10
nov
10
jan
11
mar
11
may
11
july
11
sept
11
nov
11
jan
12
mar
12
may
12
july
12
sept
12
nov
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jan
13
mar
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may
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july
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sept
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nov
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jan
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mar
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may
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july
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sept
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nov
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jan
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mar
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may
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july
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sept
15
nov
15
RelativeSearchVolume(RSV)
vaccine measles autism vaccines autism vaccine autism MMR autism vaccine measles mumps rubella autism
Aquino, F., et al. The web and public confidence in MMR vaccination in Italy. Vaccine, 2017
Rimini’s court
Milan’s court
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Vaccination coverage, Italy 2009-2015
71
85
87
89
91
93
95
97
99
2009 2010 2011 2012 2013 2014 2015
Polio MMR
%
Data source: Ministry of Health - Italy
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
72
May 2016: enough is enough
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Digital in Italy
30M active social media users on mobile
73
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
April 2015
12.000
4.800
4.600
4.100
4.000
3.100
3.400
2.600
2.200
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Echo chambers
Comilva
VaccinarSì
“borderline”
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Vaccine & Autism
on YouTube in Italian
76
2007 2009 2010 2011 2012 2013 2014 2015 2016 2017
negative 1 4 18 5 18 28 27 46 96 147
positive 0 0 0 1 0 0 13 18 42 54
neutral 0 0 0 0 2 1 8 3 5 23
0
20
40
60
80
100
120
140
160
n°ofvideos
Donzelli G, et al. Misinformation on vaccination: A quantitative analysis of YouTube videos. Hum Vaccin Immunother. 2018
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
April 2015
12.000
4.800
4.600
4.100
4.000
3.100
3.400
2.600
2.200
June 2018
11.645
23.993
21.547
27.875
20.375
19.108
10.771
361.443
55.285
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
Vaccination coverage, Italy 2009-2017
79Data source: Ministry of Health - Italy
85
87
89
91
93
95
97
99
2009 2010 2011 2012 2013 2014 2015 2016 2017
Polio MMR
%
SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016
pierluigi.lopalco@unipi.it
www.adultievaccinati.it
@PLopalcoPublic
@PLopalco
How might technology help with adult
immunisation?
David Sinclair
Director
ILC-UK
This event is kindly supported by Sanofi
#ImmuTech
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Technology and
Adult Immunisation
David Sinclair, International Longevity
Centre – UK @ilcuk @sinclairda
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The Policy Context
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
On the one hand
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The role for new technologies
 140 years ago– first two way
phone call made
 In 2000 – ½ world had never
owned a phone
 By 2007 ½ the world had a
mobile phone
 It took 75 years for telephones
to reach 50 million users
 It took 4 years for the internet
to reach 50 million
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
On the other
“Ten or 15 years ago I could fly to New York in three
and a half hours on Concorde. In the Victorian age
they built a railway in five years. There is a big
divergence here”. Rory Cellan Jones
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
And companies are beginning to recognise the
impact of ageing
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The future is bright – how can these
innovations help increase uptake of adult
vaccination?
 Using data better
 Gamification
 The Internet
 The Internet of Things
 The Sharing Economy
 Artificial Intelligence and
Robotics
 Blockchain
 Materials Science
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Who has a wearble? We like competing with
our friends
The recent growth of relatively affordable wearable
monitoring technology offers huge greater potential
to support healthy ageing.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Competition with friends might encourage us
to be healthier
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
As might financial rewards
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
But humans cheat (or maintain control?)
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Apps, Apps everywhere
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Apps, Apps, everywhere
In August 2011, the UK
Health Minister, Andrew
Lansley called on health
professionals, patients and
app designers to “suggest
ideas for health-related
smartphone apps and
information maps”.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The sharing economy
http://www.birminghammail.co.uk/whats-on/food-drink-news/brum-
chef-opens-indian-restaurant-7190927
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
More of this sort of thing?
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
More use of our data?
 It may be possible to predict dementia based on
our spending patterns.
 Royal Free allowed DeepMind to have 1.6 million
NHS records
 Chinese Government put up online for free a
dataset with 1 million to 2 million health records.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
 Every single resident was
tracked; their activity on social
networks, their purchases, their
movements, their commutes –
everything was uploaded to the
AI’s database, which then made
real-time decisions.
 Traffic congestion, road
accidents, and crime are all
down.
 It’s also wired up to everyone’s
mobile phones, informing them
of upcoming road traffic or
adverse weather conditions in
real-time.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
 New digital records have the potential to automatically
generate lists that identify undervaccinated populations,
determine which vaccines are overdue, and generate
reminders for doctors and the public.
 Nanotechnology could deliver new ways of delivering
vaccines which address the fear of the needle (e.g.
oral/nasal/Nanopatch)
 A humanoid robot might distract us from the pain.
 A ‘digital necklace’ or app could helping store our
vaccination history.
 Services like PatientsLikeMe allow patients share
information about adult vaccination with their peers
and with medical practitioners.
 Real time information services similar to Google Flu
Trends can highlight the immediate risk of vaccine
preventable diseases.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
It has taken us 20 years to get Electronic
Patient Records (and counting)
1997: Government said they would
“harness the enormous potential benefits of
IT to support the drive for quality and
efficiency in the NHS by: making patient
records electronically available when they’re
needed using the NHSnet and the Internet
to bring patients quicker test results, on-line
booking of appointments and up-to-date
specialist advice…developing telemedicine
to ensure specialist skills are available to all
parts of the country”.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
How can we better engage older people
Only 60% of retired people
agreed that technology
“makes things better”
Over half thought that
technologies “fail when you
need them most” (2)
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
How can we better engage older people
“But how much
smaller do we want
a phone?”
Some/many do want
new technology
but: “I don’t want to
live in a smart-
home – I’d rather
be dead”
Of more than 25,000 people
questioned in a 2012 survey of
attitudes in the European Union,
60 per cent thought robots that
care for children, the elderly and
the disabled should be banned
outright; and 86 per cent said
they would be
uncomfortable with one caring
for their children or parents
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
How can we engage with the ethical issues?
Moral and ethical
debates – cant afford
to ignore them
Must help older people
choose technology
when it is right for
them (tagging/urine
tests)
Privacy
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
 How do we ensure that new technology isn’t just a
gimmick, or worse, a distraction from evidence based
interventions?
 How can new technologies tackle inequalities in access
and uptake as opposed to increasing them?
 How can we “win the hearts and minds” of citizens?
 How can we ensure that regulation protects consumers
but does not prevent innovation?
 Should policymakers be looking for better evidence of
effectiveness or regulation of “apps”, games, or other
solutions?
 Inclusive Design Might a European Accessibility Act help?
 How can we tackle digital exclusion among older adults?
 How can we ensure a greater innovation focus on
adults.
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
David Sinclair
Director
International Longevity Centre - UK
Davidsinclair@ilcuk.org.uk
02073400440
Twitter: @ilcuk and @sinclairda
Q&A
This event is kindly supported by Sanofi
#ImmuTech
Putting ourselves in the shoes of someone
who isn’t vaccinated
Why don’t adults get vaccinated?
This event is kindly supported by Sanofi
#ImmuTech
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
Why don’t adults get vaccinated?
1) Develop 4 Personas (10 minutes)
2) Consider why they might not be vaccinated (10 minutes)
a) Man, 80, has not had a vaccination since he was a child
b) Man, 65, not a native speaker. Ethnic minority
c) Woman, 70, lives alone
d) Woman, 55, freelance professional
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
The Playing Cards – your job
 Playing Higher or lower, pt. I - Ideas for using
technology
 Playing Higher or lower, pt. 2 - Barriers to
using technology
 Playing higher or lower, pt. 3 - Policy and
practical solutions to using technology
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
What should you write on your cards?
On one card - one idea for using technology e.g.
– A “bot” could be used to talk people through their worries about
vaccination
– Uber could deliver a nurse to your house so you could be
vaccinated
On one card – one barrier to using technology e.g.
– People are fearful of “Fake News” and don’t trust online
messaging
– People don’t want their data shared
On one card - one Policy and practical solutions to using technology e.g.
– Good data protection regulation (GDPR?)
– Legislation to ensure easier to use websites
The International Longevity Centre-UK is an independent, non-partisan think-tank
dedicated to addressing issues of longevity, ageing and population change.
David Sinclair
Director
International Longevity Centre - UK
Davidsinclair@ilcuk.org.uk
02073400440
Twitter: @ilcuk and @sinclairda
Lunch
This event is kindly supported by Sanofi
#ImmuTech
Plan for the afternoon
David Sinclair
Director
ILC-UK
This event is kindly supported by Sanofi
#ImmuTech
Playing Higher or lower, part 1 – Ideas for
using technology
This event is kindly supported by Sanofi
#ImmuTech
Playing Higher or lower, part 2 – Barriers to
using technology
This event is kindly supported by Sanofi
#ImmuTech
Playing Higher or lower, part 3 – Policy and
practical solutions to using technology
This event is kindly supported by Sanofi
#ImmuTech
Feedback – ‘Why don’t adults get
vaccinated?’ and ‘Higher and Lower’
This event is kindly supported by Sanofi
#ImmuTech
Conclusion
This event is kindly supported by Sanofi
#ImmuTech
Bogdan Wenta MEP
Group of the European People’s Party
(Christian Democrats)
Poland
This event is kindly supported by Sanofi
#ImmuTech
Julie Girling MEP
Group of the European People’s Party
(Christian Democrats)
UK
This event is kindly supported by Sanofi
#ImmuTech
Reactions from the day
This event is kindly supported by Sanofi
#ImmuTech
Dr Wendy Yared
Director
Association of European Cancer Leagues
This event is kindly supported by Sanofi
#ImmuTech
www.europeancancerleagues.org
www.cancercode.eu 4th Revision 2014 (1st developed in 1987)
Financed by the European Commission
The European Code Against Cancer focuses on actions that individual citizens can take
to help prevent cancer.
Successful cancer prevention requires these individual actions to be supported by
governmental policies and actions.
1 Do not smoke. Do not use any form of tobacco.
2 Make your home smoke free. Support smoke-free policies in your workplace.
3 Take action to be a healthy body weight.
4 Be physically active in everyday life. Limit the time you spend sitting.
5 Have a healthy diet:
• Eat plenty of whole grains, pulses, vegetables and fruits.
• Limit high-calorie foods (foods high in sugar or fat) and avoid sugary drinks.
• Avoid processed meat; limit red meat and foods high in salt.
6 If you drink alcohol of any type, limit your intake. Not drinking alcohol is better for
cancer prevention.
www.europeancancerleagues.org
www.cancercode.eu
•www.cancercode.eu 4th Revision 2014 (1st developed in 1987)
Financed by the European Commission
7 Avoid too much sun, especially for children. Use sun protection. Do not use sunbeds.
8 In the workplace, protect yourself against cancer-causing substances by following health
and safety instructions.
9 Find out if you are exposed to radiation from naturally high radon levels in your
home. Take action to reduce high radon levels.
10 For women:
• Breastfeeding reduces the mother’s cancer risk. If you can, breastfeed your baby.
• Hormone replacement therapy (HRT) increases the risk of certain cancers. Limit use of
HRT.
11 Ensure your children take part in vaccination programmes for:
• Hepatitis B (for newborns)
• Human papillomavirus (HPV) (for girls).
12 Take part in organized cancer screening programmes for:
• Bowel cancer (men and women)
• Breast cancer (women)
• Cervical cancer (women).
www.europeancancerleagues.org
www.europeancancerleagues.org
Lana Crnjac
Interim CEO
European Liver Patients’ Association
This event is kindly supported by Sanofi
#ImmuTech
Marius Tudor
Project Manager
European Public Health Alliance
This event is kindly supported by Sanofi
#ImmuTech
Next steps
David Sinclair
Director
ILC-UK
This event is kindly supported by Sanofi
#ImmuTech

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Immunisation in a digital world - Futures Workshop

  • 1. Immunisation in a digital world: Futures Workshop Tuesday 26th June 2018 This event is kindly supported by Sanofi #ImmuTech
  • 2. Welcome and plan for the workshop David Sinclair Director ILC-UK This event is kindly supported by Sanofi #ImmuTech
  • 3. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Welcome David Sinclair, International Longevity Centre – UK @ilcuk @sinclairda
  • 4. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The specialist think tank on the impact of longevity on society, and what happens next.
  • 5. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Our work on vaccination Working with and speaking at IFA events; Event on Vaccination and AMR; Immune Response Report; SAATI report; Spoken at events in London, Brussels, San Francisco, Barcelona etc; Spoken at Academic (e.g. ECCMID; IAGG) as well as policy (IFA). Ran vaccine related events at our conference. Worked with UK and European policy-makers; House of Lords dinners; Worked with All Party Vaccination Group and ABPI Group in Parliament; Event in European Parliament; Spoke to DH Vaccine officials in Australia; Maintained and promoted website; participated in Florence Geriatric conferences; articles in media (e.g. in the Guardian). Media stories about our work on vaccination. Mentioned adult vaccination on BBC Breakfast interview.
  • 6. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Welcome 10:00 Welcome/Plan for the workshop David Sinclair, Director, ILC-UK Why is adult immunisation important and what do we need to do to increase uptake? 10:10 Speeches and Panel discussion How might technology help break down the barriers to adult immunisation? 10:50 Speeches and Q&A Putting ourselves in the shoes of someone who isn’t vaccinated 12:15 Workshop - Why don’t adults get vaccinated 12:35 Lunch 13:05 Plan for the afternoon How can technology help? Futures Workshop 13:10 Playing Higher or lower, pt. I - Ideas for using technology All 13:25 Playing Higher or lower, pt. 2 - Barriers to using technology All 13:40 Playing higher or lower, pt. 3 - Policy and practical solutions to using technology All 13:55 Feedback “Why don’t adults get vaccinated?” and “Higher and Lower” All Conclusion 14:30 Speeches and reactions 16:00 Close All
  • 7. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. What do we want from you today  Stand up; make coffee; swap groups if you want; tell us what you think.  An open mind! Have a look at the posters – Your ideas of how technology can increase uptake of adult immunisation – Your views on the barriers to the use of technology to increase uptake of adult vaccination – Your views on the policy change needed We will publish a final report in the autumn.
  • 8. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. David Sinclair Director International Longevity Centre - UK Davidsinclair@ilcuk.org.uk 02073400440 Twitter: @ilcuk and @sinclairda
  • 9. Why is adult immunisation important and what do we need to do to increase uptake? This event is kindly supported by Sanofi #ImmuTech
  • 10. Elena Gentile MEP Group of the Progressive Alliance of Socialists and Democrats Italy This event is kindly supported by Sanofi #ImmuTech
  • 11. Dave Eaton Policy and Public Affairs Manager ILC-UK This event is kindly supported by Sanofi #ImmuTech
  • 12. Daphne Holt Chair Coalition for Life-Course Immunisation This event is kindly supported by Sanofi #ImmuTech
  • 13. Peggy Maguire Director General European Institute of Women’s Health This event is kindly supported by Sanofi #ImmuTech
  • 14. This event is kindly supported by Sanofi #ImmuTech
  • 15. This event is kindly supported by Sanofi #ImmuTech
  • 16. This event is kindly supported by Sanofi #ImmuTech
  • 17. This event is kindly supported by Sanofi #ImmuTech
  • 18. This event is kindly supported by Sanofi #ImmuTech
  • 19. This event is kindly supported by Sanofi #ImmuTech
  • 20. This event is kindly supported by Sanofi #ImmuTech
  • 21. Dr Isabel De La Mata Barranco Principal Adviser for Health and Crisis Management DG Sante This event is kindly supported by Sanofi #ImmuTech
  • 22. Q&A This event is kindly supported by Sanofi #ImmuTech
  • 23. How might technology help break down the barriers to adult immunisation? This event is kindly supported by Sanofi #ImmuTech
  • 24. How the UK used technology and data to maximise uptake of vaccination David Salisbury Centre on Global Health Security Chatham House This event is kindly supported by Sanofi #ImmuTech
  • 25. Immunisation in a digital world. Prof. David Salisbury CB FRCP FRCPCH FFPH FMedSci Centre on Global Health Security, Chatham House, London.
  • 27. Birth registration • Prompt • Ubiquitous Physician registration • Call / recall • Rapid upload Local/Regional / National • Data analysis • Performance management Immunisation coverage data
  • 28. Influenza vaccination: data for management
  • 29.
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  • 33.
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  • 35. Influenza vaccine uptake for those aged 65 and over and 65 at risk from 2000 to 2001 through to 2017 to 2018 for England. WHO 2010 target is 75%. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/710416/Seasonal_influenza_vaccine_uptake_in_GP_patients_winter_season_2017 _to_2018..pdf
  • 36. Vaccine uptake in under 65s, by indication for vaccination and age, in 2010-2011 Begum, F. and R. Pebody, Seasonal influenza vaccine uptake amongst GP patient groups in England, Winter season 2010-11, 2011, Department of Health.
  • 37. Flu mortality by risk group Source – HPA: Surveillance of influenza and other respiratory viruses in the UK 2010-2011
  • 39. Impact of vaccination in 2014–2015: summary • Number needed to prevent by vaccinating children for the whole population impact – 16 children vaccination will prevent 1 GP ILI consultation – 317 children vaccination will prevent 1 influenza hospitalisation – 2205 children vaccination will prevent 1 confirmed influenza ICU/HDU admission. Primary school pilot areas versus non-pilot areas 39 Age group GP ILI consultations ED respiratory attendance Hospital admission ICU/HDU admission 5–10 years -94% OR 0.06 (0.01 – 0.62) ARD -247/100,000 popn -74% OR 0.26 (0.08 – 0.91) ARD - 9% -93% OR 0.07 (0.01 – 0.55) ARD -16/100,000 popn -76%* OR 0.24 (0.02 to 3.01) ARD -2/100,000 popn <5 years -92%* OR 0.08 (0.01 – 1.02) ARD -227/100,000 popn -65%* OR 0.35 (0.04 – 2.94) ARD - 16% -62%* OR 0.38 (0.11 – 1.32) ARD -31/100,000 popn -61%* OR 0.39 (0.06 to 2.55) ARD -3/100,000 popn >17 years -59% OR 0.41 (0.19 – 0.86) ARD -289/100,000 popn -21%* OR 0.79 (0.37 – 11.66) ARD - 1% -34%* OR 0.66 (0.22 – 11.93) ARD -14/100,000 popn -46%* OR 0.54 (0.25 to 1.16) ARD -2/100,000 popn ‘bold %’ p<0.05; * Statistically non significant; (%), confidence interval; ARD, absolute risk difference; popn, population ED, emergency department, GP, general practitioner, ILI, influenza-like illness, ICU, intensive care unit, HDU, high dependency unit ADAPTED from Pebody RG et al. Euro Surveill. 2015;20(39):pii=30029.
  • 40. Immunisation – the intersection. StrategyPolicy Informatio n Systems Performance Management
  • 41. How Big Data can address hurdles related to vaccination access & coverage Michael Greenberg, M.D., MPH Vice President and Head, Global Medical Strategy Sanofi Pasteur This event is kindly supported by Sanofi #ImmuTech
  • 42. Addressing vaccination access & coverage through Big Data Sources: 1National Diabetes Statistics Report, 2014 (released June 10, 2014) http://www.diabetes.org/diabetes-basics/statistics/?loc=db-slabnav#sthash.GuDGFjln.dpuf. Accessed April 9, 2015 | 2Gregg EW et al. N Engl J Med 2014;370:1514-1523 | 3ational Institute of Diabetes and Kidney Diseases 2009 | MICRO-VASCULAR COMPLICATIONS FOR ENDORSEMENT Global Medical Strategy, Sanofi Pasteur Michael Greenberg, MD, MPH
  • 43. 6 Million 48 Million 2 Billion 48 28
  • 44. Volume SCALE OF DATA Variety DIFFERENT FORMS OF DATA Veracity UNCERTAINTY OF DATA Velocity ANALYSIS OF STREAMING DATA Thousands of publications Flu – 50 million flu queries weekly Daily behavior of >57 000 diabetic patients VAXITREND – Internal Market Researches 20 countries; 17 000 patients, 3000 HCPs The FOUR Vs Daily Behavior information Activity trackers Daily searches Graphs / Tables Internet queries & posts Publications Lifestyle Trackers Internal data controls Data cleaning GRADE Evaluation: Evaluate the quality of medical evidence Methodological rigor Why Big Data?
  • 45. Why Flu & Diabetes? 45 We need deeper understanding to increase flu vaccine coverage HOSPITALIZATIONMetabolic complication: Decompensation, ketoacidosis , deaths Infection complication Secondary infection Influenza vaccination is recommended (and funded) DEATHS 3-6x 6x Why do people living with Diabetes do not get vaccinated (more)?
  • 46. 3-Step pilot experimentation approach 46 • Scientific data review - make sure we don’t find what is already known • Using natural language processing, machine learning, deep learning • Design methodology for understanding patient behavioral phenotypes • Run small scale real-world pilots • Experience building a datamart that unites google, sanofi and publicly available data • Emphasis on country level implementation 1 2 3
  • 47. 28/06/2018 47 EVIDATION: THE METHODOLOGY We conducted a retrospective study of influenza-related outcomes (IRO) among fully insured Type 2 diabetics from a large US payer over a 1 year period covering the 2016-17 influenza season. We used bivariate analyses (54,656 diabetics, mean age 54.8 yr, s.d. = 10.2) to compare IRO’s inferred from claims data against IRO’s for 113,016 age and gender matched non-diabetics. Samson S, Lee W et al. D Using Claims and Consumer Wearable Devices Data to Quantify Influenza-Related Outcomes among Type 2 Diabetes Patients—A Large Population Study [abstract]. ADA, Orlando, June 22, 2018.
  • 49. 28/06/2018 49 EVIDATION: THE RESULTS (2/2) Within 2-weeks before and 4- weeks after a medical claim for influenza, diabetics with influenza had more observed hyperglycemic events than in a comparable non- influenza period in the same year (p<0.001),
  • 50. 28/06/2018 50 GOOGLE: METHODOLOGY We used VaxiTrends, a proprietary dataset, to identify variables influencing vaccine uptake among adults in the U.S., China, France, Mexico, and U.K. We combined the data with National Health Interview Survey results from the CDC, which offer insights into health behaviors of Americans with diabetes. This information was aggregated with data from Google FluTrend, which signals flu incidence, & Google Trends Application Programming Interface, which tracks search keyword popularity by location & date in a de-identified fashion. Cluster analyses indicated factors most positively & negatively associated with acceptance & adherence Liska, J, Gupta A et al. D Using Claims and Consumer Wearable Devices Data to Quantify Influenza-Related Outcomes among Type 2 Diabetes Patients—A Large Population Study [abstract]. ADA, Orlando, June 22, 2018.
  • 51. GOOGLE: RESULTS 51 factors impacting flu vaccination vary by country for people living with diabetes Orderedintermsofimportance fromHighestinfluencertoLowest Negative Factors Positive Factors
  • 52. 28/06/2018 52 GOOGLE: RESULTS Adherence Impact Calculator Google created a country specific dashboard for local users to identify behavioral drivers of flu vaccination & the most receptive subgroups to design tailored interventions to increase uptake
  • 53. Access to the right data remains a barrier 53 Improved vaccine coverage estimates at finer level Individual, physician, pharmacy, workplace …not about personal data but better understanding
  • 55. WHAT do we aim at delivering and HOW? 55 … to generate end 2017 value from Medical to Business Operations 1) Augmented data value 2) Accelerated evidence generation 3) Simplicity and scale of insights 4) Actionable learnings for the business 5) Continuous insight and performance observation 1) Vaxitrend survey data for 2015 comprising of 5 countries (France, USA, UK, Mexico and China) 2) Combined with Google’s Trends and Flu Trends 3) … and NHIS* datasets 3 DATA SOURCES 5 DELIVERABLES *The National Health Interview Survey (NHIS) has monitored the health of the US nation since 1957. NHIS data on a broad range of health topics are collected through personal household interviews. November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
  • 56. China7 Quick win segment over clinical inertia 56 Insight: This group can be easily activated by a targeted campaign • High intent to vaccinate despite having zero adherence • Scared of catching flu • Takes action to protect themselves against flu • Seeks information about health issues China7 FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS November 8th 2017Flu & Diabetes – Google Pilot Advancement Status China7 àQuick win segment over clinical inertia 8 Insight: This group can be easily activated by a targeted campaign • High intent to vaccinate despite having zero adherence • Scared of catching flu • Takes action to protect themselves against flu • Seeks information about health issues China7 FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS November 8 th 2017Flu & Diabetes – Google Pilot Advancement Status
  • 57. US3 Effort intensive segment for Higher Adherence 57 Insight: This group living with Diabetes should not be prioritized • No intent to Vaccinate • Issue with Accessibility • Not in favor of Vaccination • Don’t take flu job in spite of reminders • Think that they will not be vulnerable to flu. US3 FOR ENDORSEMENTEARLY RESULTS – DRAFT VISUALISATIONS – WORK IN PROGRESS November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
  • 58. Google Influenza Trends Offers Regional Granularity 58 In a single view adherence with respect to Geographical level. Search trends for both positive and negative terms are observed . November 8th 2017Flu & Diabetes – Google Pilot Advancement Status
  • 59. KEY FACTORS IMPACTING FLU VACCINATION ADHERENCE… 59 … vary by country for people living with Diabetes Orderedintermsofimportance fromHighestinfluencertoLowest Negative Factors Positive Factors
  • 60. Social Media and Immunisation Philip Weiss Chairman ZN Consulting This event is kindly supported by Sanofi #ImmuTech
  • 62. Local views and information on the current Italian communication & digital context Prof Pier Luigi Lopalco Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa This event is kindly supported by Sanofi #ImmuTech
  • 63. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 LOCAL VIEWS AND INFORMATION ON THE CURRENT ITALIAN COMMUNICATION & DIGITAL CONTEXT Pier Luigi Lopalco 26 June 2018, Brussels
  • 67. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 Immunization coverage >64 yrs 67Data source: Ministry of Health % Pandemic vaccination campaign “Fluad case”
  • 68. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 68 Rimini’s Court: “Measles vaccine causes autism” According to judges in Milan Court there is a link between hexavalent vaccine and autism March 2012 September 2014
  • 71. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 Vaccination coverage, Italy 2009-2015 71 85 87 89 91 93 95 97 99 2009 2010 2011 2012 2013 2014 2015 Polio MMR % Data source: Ministry of Health - Italy
  • 76. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 Vaccine & Autism on YouTube in Italian 76 2007 2009 2010 2011 2012 2013 2014 2015 2016 2017 negative 1 4 18 5 18 28 27 46 96 147 positive 0 0 0 1 0 0 13 18 42 54 neutral 0 0 0 0 2 1 8 3 5 23 0 20 40 60 80 100 120 140 160 n°ofvideos Donzelli G, et al. Misinformation on vaccination: A quantitative analysis of YouTube videos. Hum Vaccin Immunother. 2018
  • 79. SItI–SezioneApulo-LucanaCorsoFADemergenzeInfetticeinSanitàPubblica-2016 Vaccination coverage, Italy 2009-2017 79Data source: Ministry of Health - Italy 85 87 89 91 93 95 97 99 2009 2010 2011 2012 2013 2014 2015 2016 2017 Polio MMR %
  • 81. How might technology help with adult immunisation? David Sinclair Director ILC-UK This event is kindly supported by Sanofi #ImmuTech
  • 82. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Technology and Adult Immunisation David Sinclair, International Longevity Centre – UK @ilcuk @sinclairda
  • 83. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The Policy Context
  • 84. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change.
  • 85. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. On the one hand
  • 86. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The role for new technologies  140 years ago– first two way phone call made  In 2000 – ½ world had never owned a phone  By 2007 ½ the world had a mobile phone  It took 75 years for telephones to reach 50 million users  It took 4 years for the internet to reach 50 million
  • 87. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. On the other “Ten or 15 years ago I could fly to New York in three and a half hours on Concorde. In the Victorian age they built a railway in five years. There is a big divergence here”. Rory Cellan Jones
  • 88. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. And companies are beginning to recognise the impact of ageing
  • 89. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The future is bright – how can these innovations help increase uptake of adult vaccination?  Using data better  Gamification  The Internet  The Internet of Things  The Sharing Economy  Artificial Intelligence and Robotics  Blockchain  Materials Science
  • 90. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Who has a wearble? We like competing with our friends The recent growth of relatively affordable wearable monitoring technology offers huge greater potential to support healthy ageing.
  • 91. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Competition with friends might encourage us to be healthier
  • 92. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. As might financial rewards
  • 93. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. But humans cheat (or maintain control?)
  • 94. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Apps, Apps everywhere
  • 95. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Apps, Apps, everywhere In August 2011, the UK Health Minister, Andrew Lansley called on health professionals, patients and app designers to “suggest ideas for health-related smartphone apps and information maps”.
  • 96. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The sharing economy http://www.birminghammail.co.uk/whats-on/food-drink-news/brum- chef-opens-indian-restaurant-7190927
  • 97. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. More of this sort of thing?
  • 98. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. More use of our data?  It may be possible to predict dementia based on our spending patterns.  Royal Free allowed DeepMind to have 1.6 million NHS records  Chinese Government put up online for free a dataset with 1 million to 2 million health records.
  • 99. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change.  Every single resident was tracked; their activity on social networks, their purchases, their movements, their commutes – everything was uploaded to the AI’s database, which then made real-time decisions.  Traffic congestion, road accidents, and crime are all down.  It’s also wired up to everyone’s mobile phones, informing them of upcoming road traffic or adverse weather conditions in real-time.
  • 100. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change.  New digital records have the potential to automatically generate lists that identify undervaccinated populations, determine which vaccines are overdue, and generate reminders for doctors and the public.  Nanotechnology could deliver new ways of delivering vaccines which address the fear of the needle (e.g. oral/nasal/Nanopatch)  A humanoid robot might distract us from the pain.  A ‘digital necklace’ or app could helping store our vaccination history.  Services like PatientsLikeMe allow patients share information about adult vaccination with their peers and with medical practitioners.  Real time information services similar to Google Flu Trends can highlight the immediate risk of vaccine preventable diseases.
  • 101. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. It has taken us 20 years to get Electronic Patient Records (and counting) 1997: Government said they would “harness the enormous potential benefits of IT to support the drive for quality and efficiency in the NHS by: making patient records electronically available when they’re needed using the NHSnet and the Internet to bring patients quicker test results, on-line booking of appointments and up-to-date specialist advice…developing telemedicine to ensure specialist skills are available to all parts of the country”.
  • 102. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. How can we better engage older people Only 60% of retired people agreed that technology “makes things better” Over half thought that technologies “fail when you need them most” (2)
  • 103. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. How can we better engage older people “But how much smaller do we want a phone?” Some/many do want new technology but: “I don’t want to live in a smart- home – I’d rather be dead” Of more than 25,000 people questioned in a 2012 survey of attitudes in the European Union, 60 per cent thought robots that care for children, the elderly and the disabled should be banned outright; and 86 per cent said they would be uncomfortable with one caring for their children or parents
  • 104. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. How can we engage with the ethical issues? Moral and ethical debates – cant afford to ignore them Must help older people choose technology when it is right for them (tagging/urine tests) Privacy
  • 105. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change.  How do we ensure that new technology isn’t just a gimmick, or worse, a distraction from evidence based interventions?  How can new technologies tackle inequalities in access and uptake as opposed to increasing them?  How can we “win the hearts and minds” of citizens?  How can we ensure that regulation protects consumers but does not prevent innovation?  Should policymakers be looking for better evidence of effectiveness or regulation of “apps”, games, or other solutions?  Inclusive Design Might a European Accessibility Act help?  How can we tackle digital exclusion among older adults?  How can we ensure a greater innovation focus on adults.
  • 106. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. David Sinclair Director International Longevity Centre - UK Davidsinclair@ilcuk.org.uk 02073400440 Twitter: @ilcuk and @sinclairda
  • 107. Q&A This event is kindly supported by Sanofi #ImmuTech
  • 108. Putting ourselves in the shoes of someone who isn’t vaccinated Why don’t adults get vaccinated? This event is kindly supported by Sanofi #ImmuTech
  • 109. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. Why don’t adults get vaccinated? 1) Develop 4 Personas (10 minutes) 2) Consider why they might not be vaccinated (10 minutes) a) Man, 80, has not had a vaccination since he was a child b) Man, 65, not a native speaker. Ethnic minority c) Woman, 70, lives alone d) Woman, 55, freelance professional
  • 110. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. The Playing Cards – your job  Playing Higher or lower, pt. I - Ideas for using technology  Playing Higher or lower, pt. 2 - Barriers to using technology  Playing higher or lower, pt. 3 - Policy and practical solutions to using technology
  • 111. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. What should you write on your cards? On one card - one idea for using technology e.g. – A “bot” could be used to talk people through their worries about vaccination – Uber could deliver a nurse to your house so you could be vaccinated On one card – one barrier to using technology e.g. – People are fearful of “Fake News” and don’t trust online messaging – People don’t want their data shared On one card - one Policy and practical solutions to using technology e.g. – Good data protection regulation (GDPR?) – Legislation to ensure easier to use websites
  • 112. The International Longevity Centre-UK is an independent, non-partisan think-tank dedicated to addressing issues of longevity, ageing and population change. David Sinclair Director International Longevity Centre - UK Davidsinclair@ilcuk.org.uk 02073400440 Twitter: @ilcuk and @sinclairda
  • 113. Lunch This event is kindly supported by Sanofi #ImmuTech
  • 114. Plan for the afternoon David Sinclair Director ILC-UK This event is kindly supported by Sanofi #ImmuTech
  • 115. Playing Higher or lower, part 1 – Ideas for using technology This event is kindly supported by Sanofi #ImmuTech
  • 116. Playing Higher or lower, part 2 – Barriers to using technology This event is kindly supported by Sanofi #ImmuTech
  • 117. Playing Higher or lower, part 3 – Policy and practical solutions to using technology This event is kindly supported by Sanofi #ImmuTech
  • 118. Feedback – ‘Why don’t adults get vaccinated?’ and ‘Higher and Lower’ This event is kindly supported by Sanofi #ImmuTech
  • 119. Conclusion This event is kindly supported by Sanofi #ImmuTech
  • 120. Bogdan Wenta MEP Group of the European People’s Party (Christian Democrats) Poland This event is kindly supported by Sanofi #ImmuTech
  • 121. Julie Girling MEP Group of the European People’s Party (Christian Democrats) UK This event is kindly supported by Sanofi #ImmuTech
  • 122. Reactions from the day This event is kindly supported by Sanofi #ImmuTech
  • 123. Dr Wendy Yared Director Association of European Cancer Leagues This event is kindly supported by Sanofi #ImmuTech
  • 124. www.europeancancerleagues.org www.cancercode.eu 4th Revision 2014 (1st developed in 1987) Financed by the European Commission The European Code Against Cancer focuses on actions that individual citizens can take to help prevent cancer. Successful cancer prevention requires these individual actions to be supported by governmental policies and actions. 1 Do not smoke. Do not use any form of tobacco. 2 Make your home smoke free. Support smoke-free policies in your workplace. 3 Take action to be a healthy body weight. 4 Be physically active in everyday life. Limit the time you spend sitting. 5 Have a healthy diet: • Eat plenty of whole grains, pulses, vegetables and fruits. • Limit high-calorie foods (foods high in sugar or fat) and avoid sugary drinks. • Avoid processed meat; limit red meat and foods high in salt. 6 If you drink alcohol of any type, limit your intake. Not drinking alcohol is better for cancer prevention.
  • 125. www.europeancancerleagues.org www.cancercode.eu •www.cancercode.eu 4th Revision 2014 (1st developed in 1987) Financed by the European Commission 7 Avoid too much sun, especially for children. Use sun protection. Do not use sunbeds. 8 In the workplace, protect yourself against cancer-causing substances by following health and safety instructions. 9 Find out if you are exposed to radiation from naturally high radon levels in your home. Take action to reduce high radon levels. 10 For women: • Breastfeeding reduces the mother’s cancer risk. If you can, breastfeed your baby. • Hormone replacement therapy (HRT) increases the risk of certain cancers. Limit use of HRT. 11 Ensure your children take part in vaccination programmes for: • Hepatitis B (for newborns) • Human papillomavirus (HPV) (for girls). 12 Take part in organized cancer screening programmes for: • Bowel cancer (men and women) • Breast cancer (women) • Cervical cancer (women).
  • 128. Lana Crnjac Interim CEO European Liver Patients’ Association This event is kindly supported by Sanofi #ImmuTech
  • 129. Marius Tudor Project Manager European Public Health Alliance This event is kindly supported by Sanofi #ImmuTech
  • 130. Next steps David Sinclair Director ILC-UK This event is kindly supported by Sanofi #ImmuTech