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This document discusses an alkaline water ionizer company that has been in business for 40 years. It manufactures medical technology and alkaline ionizers, and is currently operating in 11 countries. The company has a world-class advisory board and produces eco-friendly products. Its corporate philosophy focuses on realizing true physical, financial, and mental health. The document provides information on the company's continuous ionized electrolysis water generator and compensation plan.
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Img.kgn.demo.2014
This document discusses an alkaline water ionizer company. It provides information about the company such as it being a 40-year old Japanese company that manufactures medical technology and alkaline ionizers. It operates in 11 countries and has a world class advisory board. The document discusses the company's philosophy of realizing true physical, financial, and mental health. It provides details about its continuous ionized electrolysis water generator and compensation plan. It promotes the benefits of the water ionizer such as reducing medical costs and supporting a healthier lifestyle.
Img.kgn.hangout.2014
This document discusses Enagic, a 40-year old Japanese company that manufactures medical technology, including alkaline ionizers. It operates in 11 countries and has received numerous awards for its products. Enagic's corporate philosophy focuses on realizing true physical, financial, and mental health. The document provides information on Enagic's flagship water ionizer product, including its 15-year shelf life and comparison of ionized water to other beverages and purified water options in terms of pH levels. It also briefly mentions Enagic's compensation plan and cost savings from using the ionized water system.
KANGEN ONLINE DEMO - GOOGLE HANGOUTS
This document provides information about Enagic, a 40-year old Japanese company that manufactures medical technology, including alkaline ionizers. It discusses Enagic's corporate philosophy of realizing true physical, financial, and mental health. The document also describes some of Enagic's products, such as its Continuous Ionized Electrolysis Water Generator, and how its ionized water clusters are smaller than regular water clusters, allowing for better absorption by the body.
Img.kgn.hangout.2014
This document discusses acid reflux, alkalinity, and pH levels in the body. It then provides information about Kangen water machines produced by Enagic, including the company history and benefits of alkaline ionized water. Key details are that Enagic has been producing water ionizers for over 40 years and is a worldwide leader in the industry. The water produced by their machines is said to have a higher pH and provide health benefits by balancing the body's pH levels.
Img.kgn.hangout.2014
This document discusses acid reflux, indigestion, diarrhea and constipation as illnesses affected by pH balance. It then discusses Enagic, a 40-year old Japanese company that manufactures alkaline ionizers and has a worldwide leadership position in that industry. It notes Enagic's focus on physical, financial and mental health in its corporate philosophy and promotes the benefits and affordability of its ionized water generator products.
Img.kgn.hangout.2014
This document discusses alkaline ionized water and its benefits. It notes that maintaining a body's pH balance at 7.35 through alkalinity is essential. It then discusses various water types on the pH scale, with Kangen water being one of the most alkaline. The document promotes Enagic as a 40 year old Japanese company that is a worldwide leader in alkaline ionizers and manufactures medical technology. It notes Enagic's philosophy is based on realizing true physical, financial and mental health. The document encourages considering the benefits of an Enagic alkaline water system such as easy installation, reduced medical costs, a healthier lifestyle and affordable payments.
Img.kgn.hangout.2014
This document discusses the importance of maintaining a balanced pH level in the body and discusses how consuming alkaline ionized water can help support overall health and wellness. It summarizes the history and credentials of Enagic, a leading producer of alkaline ionized water machines, and their philosophy of empowering customers with tools to realize true physical, financial, and mental health. The document also outlines the benefits of the Enagic machines and an affordable payment plan for purchasing an ionizer.
Img.kgn.demo.2014
The document discusses topics related to health including acid reflux, pH balance, and water quality. It then summarizes information about a company called Enagic that manufactures alkaline ionizer water purification systems. Key details provided include that Enagic has been operating for 40 years, is Japanese owned, manufactures medical technology, and is a worldwide leader in alkaline ionizers.
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Img.kgn.demo.2014
This document discusses an alkaline water ionizer company. It provides information about the company such as it being a 40-year old Japanese company that manufactures medical technology and alkaline ionizers. It operates in 11 countries and has a world class advisory board. The document discusses the company's philosophy of realizing true physical, financial, and mental health. It provides details about its continuous ionized electrolysis water generator and compensation plan. It promotes the benefits of the water ionizer such as reducing medical costs and supporting a healthier lifestyle.
Img.kgn.hangout.2014
This document discusses Enagic, a 40-year old Japanese company that manufactures medical technology, including alkaline ionizers. It operates in 11 countries and has received numerous awards for its products. Enagic's corporate philosophy focuses on realizing true physical, financial, and mental health. The document provides information on Enagic's flagship water ionizer product, including its 15-year shelf life and comparison of ionized water to other beverages and purified water options in terms of pH levels. It also briefly mentions Enagic's compensation plan and cost savings from using the ionized water system.
KANGEN ONLINE DEMO - GOOGLE HANGOUTS
This document provides information about Enagic, a 40-year old Japanese company that manufactures medical technology, including alkaline ionizers. It discusses Enagic's corporate philosophy of realizing true physical, financial, and mental health. The document also describes some of Enagic's products, such as its Continuous Ionized Electrolysis Water Generator, and how its ionized water clusters are smaller than regular water clusters, allowing for better absorption by the body.
Img.kgn.hangout.2014
This document discusses acid reflux, alkalinity, and pH levels in the body. It then provides information about Kangen water machines produced by Enagic, including the company history and benefits of alkaline ionized water. Key details are that Enagic has been producing water ionizers for over 40 years and is a worldwide leader in the industry. The water produced by their machines is said to have a higher pH and provide health benefits by balancing the body's pH levels.
Img.kgn.hangout.2014
This document discusses acid reflux, indigestion, diarrhea and constipation as illnesses affected by pH balance. It then discusses Enagic, a 40-year old Japanese company that manufactures alkaline ionizers and has a worldwide leadership position in that industry. It notes Enagic's focus on physical, financial and mental health in its corporate philosophy and promotes the benefits and affordability of its ionized water generator products.
Img.kgn.hangout.2014
This document discusses alkaline ionized water and its benefits. It notes that maintaining a body's pH balance at 7.35 through alkalinity is essential. It then discusses various water types on the pH scale, with Kangen water being one of the most alkaline. The document promotes Enagic as a 40 year old Japanese company that is a worldwide leader in alkaline ionizers and manufactures medical technology. It notes Enagic's philosophy is based on realizing true physical, financial and mental health. The document encourages considering the benefits of an Enagic alkaline water system such as easy installation, reduced medical costs, a healthier lifestyle and affordable payments.
Img.kgn.hangout.2014
This document discusses the importance of maintaining a balanced pH level in the body and discusses how consuming alkaline ionized water can help support overall health and wellness. It summarizes the history and credentials of Enagic, a leading producer of alkaline ionized water machines, and their philosophy of empowering customers with tools to realize true physical, financial, and mental health. The document also outlines the benefits of the Enagic machines and an affordable payment plan for purchasing an ionizer.
Img.kgn.demo.2014
The document discusses topics related to health including acid reflux, pH balance, and water quality. It then summarizes information about a company called Enagic that manufactures alkaline ionizer water purification systems. Key details provided include that Enagic has been operating for 40 years, is Japanese owned, manufactures medical technology, and is a worldwide leader in alkaline ionizers.
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Juan DíAz Covarrubias
Juan Díaz Covarrubias fue un novelista y poeta romántico mexicano del siglo XIX. Estudió filosofía, latín y medicina. Fue colaborador de varios periódicos y defensor de los ideales liberales y reformistas. En 1859 publicó tres novelas notables - El diablo en México, La clase media y Gil Gómez, El insurgente - en las que describió paisajes y costumbres mexicanas. Se le considera uno de los iniciadores del romanticismo en México y murió en la Ciudad de México
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Este documento describe los cambios en la sociedad hacia una economía basada en el conocimiento y los servicios en lugar de los bienes producidos. Brevemente resume cinco puntos clave: 1) El trabajador del conocimiento obtiene empleo basado en educación formal y conocimientos especializados; 2) El capital intelectual reemplaza la producción física; 3) Las nuevas tecnologías permiten trabajar de forma flexible; 4) Aprender a aprender se vuelve clave ya que nadie posee todos los conocimientos; 5) Los valores sociales se vuel
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1) El principal problema identificado por la comunidad a través del censo es la inseguridad, con un 48%.
2) En segundo lugar está la cercanía de las viviendas al río, con un 17.27%, lo que puede causar inundaciones y contaminación.
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This advert promotes Plan B's album "Ill Manors", which serves as the soundtrack to his gangster/crime film of the same name. The black, white, and red color scheme represents the themes of life, death, and violence in the film. The picture features a man smoking on a wall in an urban setting, conveying themes of rebellion and feeling trapped in a poor area. Through use of positioning, fonts, and color, the advert draws attention to key details like the artist, album title, and release date to promote interest and sales.
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This document discusses pH balance and alkalinity in the body. It notes that with a body's pH at 7.35, alkalinity is essential to maintain health and avoid issues like acid reflux, indigestion, diarrhea and constipation. It then discusses Enagic, a 40-year old Japanese company that manufactures alkaline ionizers and received numerous awards for their products and corporate philosophy of realizing true physical, financial and mental health. Finally, it provides a hypothetical compensation plan showing potential earnings from the company.
Img.kgn.demo.2014
- The document discusses the importance of maintaining a balanced pH level in the body of 7.35 through ensuring proper alkalinity.
- It provides information about Enagic, a 40-year old Japanese company that manufactures medical technology products and is a worldwide leader in alkaline ionizers.
- Enagic has a customer-first philosophy and compensation plan that allows users to earn income through the company's direct selling model by sharing its eco-friendly alkaline water ionizer products.
Img.kgn.demo.2014
This document discusses the importance of maintaining pH balance in the body and introduces Enagic, a company that manufactures alkaline ionizers. Key points:
- The body's ideal pH balance is 7.35, and alkalinity is essential for maintaining this balance.
- Enagic is a 40-year-old, Japanese-owned company that produces medical technology and is a worldwide leader in alkaline ionizers.
- Enagic ionizers are eco-friendly and help reduce medical costs while supporting a healthier lifestyle through easier water filtration and cleaning.
Img.kgn.hangout.2014
This document discusses acid reflux, alkalinity, and pH levels in the body. It then provides information about Kangen water machines produced by Enagic, including the company history and benefits of alkaline ionized water. Key details are that Enagic has been producing water ionizers for over 40 years and is a leader in the industry. The water produced by their machines is said to have a higher pH and provide health benefits by balancing the body's pH levels.
Img.kgn.hangout.2014
This document discusses acid reflux, indigestion, diarrhea and constipation as illnesses affected by pH balance. It then discusses Enagic, a 40-year old Japanese company that manufactures medical technology including alkaline ionizers and has a worldwide leadership position in that industry. It notes Enagic's focus on health, affordable payments, and ease of installation for its ionizer products.
Img.kgn.hangout1.2014
This document discusses the benefits of alkaline ionized water and Enagic water ionizers. It notes that maintaining a body's pH balance at 7.35 through alkalinity is essential for gastrointestinal health. The Enagic company manufactures medical technology and water ionizers. Their ionizers produce micro-clustered water that has antioxidant and alkaline properties beneficial for general health and reducing medical costs. Enagic has numerous awards and is a worldwide leader in alkaline ionizers.
Sportsnutritionpresentationpdf 090817041948 Phpapp02
This is an excellent sports nutrition presentation created by an Herbalife distributor from South Africa. Well done Neville.
Reliv Opportunity Slides 2012
This document summarizes Reliv, a company that provides nutritional supplements. It highlights Reliv's mission to nourish the world through nutrition that supports body, mind and spirit. It describes Reliv's product line, including supplements for essential nutrition, weight loss, and targeted solutions. It also outlines Reliv's business opportunity as a direct seller of these supplements, with a proven business model and path to success.
Maripet minowa product demo (1)
This document welcomes the reader to Japan and introduces a company that has achieved recognition among the top 20,000 companies for remitting withholding tax. The company's partner is debt-free, publicly traded, has many product lines approved by regulatory agencies, extensively researches and develops products through clinical studies, and is a leading herbal supplement company. The document then discusses factors affecting health and the benefits of prevention over cure, listing the nutrients contained in the company's product which combines fruit, vegetable, mushroom, and specialty extracts and is designed to enhance absorption and alkalinity for nutrient purity and potency.
Img.kgn.webinar.2015
This document discusses acid reflux, indigestion, and other illnesses. It describes Enagic's corporate philosophy of realizing mental, physical, and financial health. It also discusses Kangen water and its benefits, such as its micro-clusters and antioxidant properties. The document outlines Enagic's expansion globally since introducing its consumer water ionizer version in 1994.
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This document summarizes why Herbalife is a good company to join now. It outlines that Herbalife has been in business for 33 years, has 65 million customers and 2.6 million distributors worldwide. It notes the worldwide obesity epidemic and cites Herbalife's science-based products and clinical studies. The document also promotes Herbalife's business opportunity, branding partnerships, commitment to its vision and ethics, and work with the Herbalife Family Foundation to help children in need. It closes by stating now is the right time to join Herbalife due to global health and economic challenges, and that the company offers a way to feel good, earn extra income, and achieve financial freedom.
EN Collection Health 2017.2
The complete LR Health & Nutrition Collection, for the second Semester of 2017.
Contents:
In micro nutrients and balanced diet concept section:
Dietary Supplements,
Weight management,
Aloe Vera Drinking Gel,
Colostrum,
Specialized products
In Functional Care section:
Aloe Vera Care,
Anti-bacterial Support
For more info: https://goo.gl/YILUpS
RBP Singapore
Royalè Direct Sales Pte. Ltd. is the exclusive importer and distributor of health, wellness, and beauty products from Royale Business Club International Inc. in the Philippines. The company markets food supplements, powdered beverages, and personal care products through a network of independent distributors. Distributors can join by attending a presentation, submitting an application, and purchasing products to reach 150 product points. This allows distributors to receive discounts on purchases and access tracking and marketing tools through an online system. The document provides details on popular products, incentives for distributors including bonuses and travel, and package options to become a distributor.
Lnqi company profile
The company was founded in 2008 in Quezon City, Philippines by doctors and entrepreneurs to distribute health supplements. It entered into an exclusive partnership with AFC-HD AMS Life Science Co. Ltd. of Japan to import and market their supplement, pharmaceutical, and cosmetic products in the Philippines. Life and Natures Quest Intl. Inc. is run by doctors and specializes in research and development of supplements and alternative medicines. It aims to provide affordable, high-quality health products from its manufacturer partner in Japan.
LNQI company profile
The company was founded in 2008 in Quezon City, Philippines by doctors and entrepreneurs to distribute health supplements. It entered into an exclusive partnership with AFC-HD AMS Life Science Co. Ltd. of Japan to import and market their supplement, pharmaceutical, and cosmetic products in the Philippines. Life and Natures Quest Intl. Inc. is licensed by the Philippines FDA to legally import and distribute these health products in the country. It aims to provide affordable, high-quality supplements and beauty products.
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Este documento presenta la información de un proyecto para fomentar la lectura en colegios vulnerables a través de mejorar las bibliotecas escolares. Detalla los roles de los integrantes del equipo, un mapa de empatía con citas relevantes, y una definición del problema basada en datos. Luego presenta una lluvia de ideas de posibles soluciones y una versión inicial y final de un modelo de negocio para el proyecto, el cual incluye asesoría a bibliotecarios, capacitación, y una red de bibliotecas.
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Panama presentation.
The document discusses Panama's uprising and the involvement of the United States in the Panama Canal. It also talks about how the treaty helped Panama and how the country has expanded since then.
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Este documento describe los cambios en la sociedad hacia una economía basada en el conocimiento y los servicios en lugar de los bienes producidos. Brevemente resume cinco puntos clave: 1) El trabajador del conocimiento obtiene empleo basado en educación formal y conocimientos especializados; 2) El capital intelectual reemplaza la producción física; 3) Las nuevas tecnologías permiten trabajar de forma flexible; 4) Aprender a aprender se vuelve clave ya que nadie posee todos los conocimientos; 5) Los valores sociales se vuel
problemas
El resumen del documento es:
1) El principal problema identificado por la comunidad a través del censo es la inseguridad, con un 48%.
2) En segundo lugar está la cercanía de las viviendas al río, con un 17.27%, lo que puede causar inundaciones y contaminación.
3) La ineficiencia del servicio de aseo urbano es el tercer problema más común, reportado por un 14% de la comunidad.
Ill manors plan b analysis
This advert promotes Plan B's album "Ill Manors", which serves as the soundtrack to his gangster/crime film of the same name. The black, white, and red color scheme represents the themes of life, death, and violence in the film. The picture features a man smoking on a wall in an urban setting, conveying themes of rebellion and feeling trapped in a poor area. Through use of positioning, fonts, and color, the advert draws attention to key details like the artist, album title, and release date to promote interest and sales.
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This document discusses pH balance and alkalinity in the body. It notes that with a body's pH at 7.35, alkalinity is essential to maintain health and avoid issues like acid reflux, indigestion, diarrhea and constipation. It then discusses Enagic, a 40-year old Japanese company that manufactures alkaline ionizers and received numerous awards for their products and corporate philosophy of realizing true physical, financial and mental health. Finally, it provides a hypothetical compensation plan showing potential earnings from the company.
Img.kgn.demo.2014
- The document discusses the importance of maintaining a balanced pH level in the body of 7.35 through ensuring proper alkalinity.
- It provides information about Enagic, a 40-year old Japanese company that manufactures medical technology products and is a worldwide leader in alkaline ionizers.
- Enagic has a customer-first philosophy and compensation plan that allows users to earn income through the company's direct selling model by sharing its eco-friendly alkaline water ionizer products.
Img.kgn.demo.2014
This document discusses the importance of maintaining pH balance in the body and introduces Enagic, a company that manufactures alkaline ionizers. Key points:
- The body's ideal pH balance is 7.35, and alkalinity is essential for maintaining this balance.
- Enagic is a 40-year-old, Japanese-owned company that produces medical technology and is a worldwide leader in alkaline ionizers.
- Enagic ionizers are eco-friendly and help reduce medical costs while supporting a healthier lifestyle through easier water filtration and cleaning.
Img.kgn.hangout.2014
This document discusses acid reflux, alkalinity, and pH levels in the body. It then provides information about Kangen water machines produced by Enagic, including the company history and benefits of alkaline ionized water. Key details are that Enagic has been producing water ionizers for over 40 years and is a leader in the industry. The water produced by their machines is said to have a higher pH and provide health benefits by balancing the body's pH levels.
Img.kgn.hangout.2014
This document discusses acid reflux, indigestion, diarrhea and constipation as illnesses affected by pH balance. It then discusses Enagic, a 40-year old Japanese company that manufactures medical technology including alkaline ionizers and has a worldwide leadership position in that industry. It notes Enagic's focus on health, affordable payments, and ease of installation for its ionizer products.
Img.kgn.hangout1.2014
This document discusses the benefits of alkaline ionized water and Enagic water ionizers. It notes that maintaining a body's pH balance at 7.35 through alkalinity is essential for gastrointestinal health. The Enagic company manufactures medical technology and water ionizers. Their ionizers produce micro-clustered water that has antioxidant and alkaline properties beneficial for general health and reducing medical costs. Enagic has numerous awards and is a worldwide leader in alkaline ionizers.
Sportsnutritionpresentationpdf 090817041948 Phpapp02
This is an excellent sports nutrition presentation created by an Herbalife distributor from South Africa. Well done Neville.
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This document summarizes Reliv, a company that provides nutritional supplements. It highlights Reliv's mission to nourish the world through nutrition that supports body, mind and spirit. It describes Reliv's product line, including supplements for essential nutrition, weight loss, and targeted solutions. It also outlines Reliv's business opportunity as a direct seller of these supplements, with a proven business model and path to success.
Maripet minowa product demo (1)
This document welcomes the reader to Japan and introduces a company that has achieved recognition among the top 20,000 companies for remitting withholding tax. The company's partner is debt-free, publicly traded, has many product lines approved by regulatory agencies, extensively researches and develops products through clinical studies, and is a leading herbal supplement company. The document then discusses factors affecting health and the benefits of prevention over cure, listing the nutrients contained in the company's product which combines fruit, vegetable, mushroom, and specialty extracts and is designed to enhance absorption and alkalinity for nutrient purity and potency.
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This document discusses acid reflux, indigestion, and other illnesses. It describes Enagic's corporate philosophy of realizing mental, physical, and financial health. It also discusses Kangen water and its benefits, such as its micro-clusters and antioxidant properties. The document outlines Enagic's expansion globally since introducing its consumer water ionizer version in 1994.
Why herbalife why now?
This document summarizes why Herbalife is a good company to join now. It outlines that Herbalife has been in business for 33 years, has 65 million customers and 2.6 million distributors worldwide. It notes the worldwide obesity epidemic and cites Herbalife's science-based products and clinical studies. The document also promotes Herbalife's business opportunity, branding partnerships, commitment to its vision and ethics, and work with the Herbalife Family Foundation to help children in need. It closes by stating now is the right time to join Herbalife due to global health and economic challenges, and that the company offers a way to feel good, earn extra income, and achieve financial freedom.
EN Collection Health 2017.2
The complete LR Health & Nutrition Collection, for the second Semester of 2017.
Contents:
In micro nutrients and balanced diet concept section:
Dietary Supplements,
Weight management,
Aloe Vera Drinking Gel,
Colostrum,
Specialized products
In Functional Care section:
Aloe Vera Care,
Anti-bacterial Support
For more info: https://goo.gl/YILUpS
RBP Singapore
Royalè Direct Sales Pte. Ltd. is the exclusive importer and distributor of health, wellness, and beauty products from Royale Business Club International Inc. in the Philippines. The company markets food supplements, powdered beverages, and personal care products through a network of independent distributors. Distributors can join by attending a presentation, submitting an application, and purchasing products to reach 150 product points. This allows distributors to receive discounts on purchases and access tracking and marketing tools through an online system. The document provides details on popular products, incentives for distributors including bonuses and travel, and package options to become a distributor.
Lnqi company profile
The company was founded in 2008 in Quezon City, Philippines by doctors and entrepreneurs to distribute health supplements. It entered into an exclusive partnership with AFC-HD AMS Life Science Co. Ltd. of Japan to import and market their supplement, pharmaceutical, and cosmetic products in the Philippines. Life and Natures Quest Intl. Inc. is run by doctors and specializes in research and development of supplements and alternative medicines. It aims to provide affordable, high-quality health products from its manufacturer partner in Japan.
LNQI company profile
The company was founded in 2008 in Quezon City, Philippines by doctors and entrepreneurs to distribute health supplements. It entered into an exclusive partnership with AFC-HD AMS Life Science Co. Ltd. of Japan to import and market their supplement, pharmaceutical, and cosmetic products in the Philippines. Life and Natures Quest Intl. Inc. is licensed by the Philippines FDA to legally import and distribute these health products in the country. It aims to provide affordable, high-quality supplements and beauty products.
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Market Australia product catalogue
Market Australia is a Global, Internet Business, dealing with multibillion dollar markets such as Health and Nutrition, Anti-ageing, Cosmetics, Skin-care, Weight Management and Website Building and Management.
These products are available from http://au.shop.com/meow888 or http://global.shop.com/meow888
In addition to its own products shown in the catalogue here, the web-portal http://au.shop.com/meow888 also include thousands of products from hundreds of partner stores.
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4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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- 9. With a body’s ph balance at 7.35, alkalinity is essential…With a body’s ph balance at 7.35, alkalinity is essential… PH= Potential Hydrogen, Scale = 14.0PH= Potential Hydrogen, Scale = 14.0
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