1) The document discusses the key factors for building an advanced cardiovascular hybrid operating room, including clinical requirement assessment, planning, project management, and partner management. 2) Some of the main considerations for a hybrid OR layout are ensuring adequate space for imaging equipment, surgical equipment, anesthesia equipment, and radiation shielding. Workflow for medical staff and patients must also be considered. 3) Building a hybrid OR requires defining roles and responsibilities, deciding on equipment, and iterative planning and verification between all involved parties to ensure needs are met. Total investment for a hybrid OR project can be over $6 million.