SEO (search engine optimization) is important for businesses to be visible in search results. React applications can be challenging for SEO because search engines cannot see content rendered by JavaScript. Some key challenges are delays in indexing content, slow page loads, and inability to read metadata and create sitemaps. Techniques like prerendering, server-side rendering, and tools like React Helmet and Next.js help make React apps more SEO-friendly by rendering content on the server so search engines can index pages fully.