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HIV
By : Zain al abdeen
Outline

•    Definitions
•    Presence of HIV/AIDS Worldwide
•   Diagnosis
•   Infection
•   Transmission
•   Treatment
•   Nutrition – Treatment
Definitions

• HIV: Human Immunodeficiency
  Virus – a retrovirus that targets the
  CD4 T helper immune cells

• AIDS: Acquired Immunodeficiency
  Syndrome – the final stage of HIV
  infection
Presence of HIV/AIDS Worldwide
Diagnosis of advanced HIV to AIDS

•    Three Criteria:
    1. A CD4+ cell count of less than 200 cells per
       microliter
    2. A CD4+ cell count that comprises of less
       than 14% lymphocytes present
    3. And/or an AIDS defining illness
        – bacterial infections, wasting syndrome
Diagnosis
• Screening Tests licensed by the FDA
  – Test serum or plasma with high sensitivity
    to HIV type 1 (HIV-1) antibodies
     • Enzyme-Linked Immunoabsorbent Assay
       (ELISA)
  – Confirmatory test
     • ELISA, Enzyme Immunoassay (EIA), Western
       blot, modified Western blot, and line
       immunoassay (LIA)
  – Combination ELISA testing
     • Both antigen and antibodies
     • Earlier diagnosis
Infection
Infection
• New HIV Infections by Age Group
Transmission
Transmission

• Through Bodily Fluids :

1- Blood products
2- Vaginal fluids
3- Semen
4- Breast Milk
Transmission

• Sharing Needles
    – Without sterilization
    – 8%

•    Mother-to-Baby
    Before Birth
   During Birth
   After the birth
   Vertical transmission before birth or
    through breastfeeding = <1%
Transmission
• Through Sex

  # Intercourse
  # Oral sex
  # Anal sex
  # Digital Sex

     • Male-to-male = 54%
     • Heterosexual = 34%
Stages of HIV
• Stage 1

• Short, flu-like illness - occurs one to six
  weeks after infection
• no symptoms at all
• Infected person can infect other people
Stages of HIV
• Stage 2
• Lasts for an average of ten years
• This stage is free from symptoms
• There may be swollen glands
• The level of HIV in the blood drops to
  very low levels
• HIV antibodies are detectable in the
  blood
Stages of HIV
• Stage 3

• The symptoms are mild
• The immune system drop
• emergence of infections and cancers
Stages of HIV
• Stage 4

• The immune system weakens
• The illnesses become more severe
  leading to an AIDS diagnosis
Treatment


• Antiretroviral Therapies (ART)
• Highly active retroviral therapy (HAART)
• Aimed at interrupting viral life cycle and
  decreasing viral load
Nutrition – Treatment
• Goals:
  – Preserve body cell mass
  – Provide adequate amounts of all nutrients for
    proper function
  – Minimize the symptoms
Nutrition – Treatment
• Energy Needs :
• Energy – based on need to maintain
  weight
   – Harris-Benedict Formula + extra kcal as
     needed
   – 20-30% increased energy for recovery from
     infections
• Protein – increased for infection
   – 1.2 – 1.8 g/kg/day
• Females: at least 100 grams of protein per day
• Males: at least 125 grams of protein per day
Nutrition – Treatment
• Reduce Fat :

• Fat can be hard for your body to digest
  when you have HIV diseases , it can
  cause diarrhea, nausea, gas and bloating
Nutrition – Treatment
• High Nutrient Foods
 Yogurt       Tuna         Beans      Leafy       Brown Rice
 Cheese      Chicken       Lentils    Greens        Whole
  Eggs        Fish          Corn      Squash        Grains
 Cottage                               Yams
 Cheese



  Tofu,        All        Oatmeal     All Fruit     Peanut
 Tempeh,    Vegetables   Wheat Germ   Broccoli      Butter
 Soy Nuts                                            Nuts
Nutrition – Treatment
• Micronutrient Needs
• Dietary Reference Intakes
  – Vitamin A – 700-900 μg/day
      • Immune function
  – Vitamin E – 15 mg/day
      • Immune function – antioxidant protection
  – Vitamin B12 – 2.4 mcg/day
      • Cognitive function
  – Selenium – 55 μg/day
      • Immune function – antioxidant protection
  – Zinc – 8-11mg/day
      • Immune function, slowed disease progression
Nutrition – Treatment

• Symptom Management
  – Nausea and Vomiting
    •   Replace fluids and electrolytes
    •   Bland, odorless foods
    •   Beverages between meals
    •   Smaller, more frequent meals
    •   Reduce fatty foods with early satiety
Nutrition – Treatment
• Symptom Management
  – Diarrhea
    • Replace fluids and electrolytes – juice, sports
      drinks, gelatin
    • Bland foods low in fiber
    • Avoid fatty and gassy foods
    • Avoid lactose if problematic
Nutrition – Treatment

• Symptom Management
  – Anorexia
    •   Eat favorite foods often in relaxed settings
    •   Add flavors and an array of colors
    •   Keep snacks handy
    •   Appetite stimulants
Nutrition – Treatment

• Symptom Management
  – Oral ,chewing & swallowing problems
    •   Moist, soft, and finely diced foods
    •   Avoid spicy or acid-containing foods
    •   Room temperature or cooler foods
    •   Topical medicines
Nutrition – Treatment
• Common Deficiencies :

• Vitamin A, zinc, iron- detrimental to the
  immune function
• antioxidants- Vit A, Vit. C, and B
  vitamins can also compromise immune
  function b/c of their roles as cofactors in
  many enzyme functions including those
  involved in nucleic acid synthesis
Social strategies
• Social strategies do not require any
  drug or object to be effective , but
  rather require persons to change their
  behavior in order to gain protection
  from HIV
• Some social strategies which people
  consider include the following :
• sex education
• Safe injection sites
• Sexual abstinence
No comment
REFERENCES
•   Grinspoon S, Mulligan K. For the Department of Health and Human
    Services working group on the prevention and treatment of wasting and
    weight loss. HIV related weight loss and wasting. In Supplement:
    Integrating nutrition management into HIV medical management.Guest
    Editor, Celia Hayes. Clinical Infectious Diseases, 2003,
•   ME Brecher, et al. Is It HIV TTP or HIV-Associated Thrombotic
    Microangiopathy? J of Clin Apheresis. 2008
•   Fawzi, W., Msamanga, G., Spiegelman, D., Hunter, D. (2005). Studies of
    Vitamins and Minerals and HIV Transmission and Disease Progression.
    The Journal of Nutrition, 135, 938-944.
•   Fields-Gardner, Cade, & Fergusson, Pamela. (2004). Position of the
    American Dietetic Association and Dietitians of Canada: Nutrition
    Intervention in the care of Persons with Human Immunodeficiency Virus
    Infection. Journal of The American Dietetic Association, 104(9), 1425-
    1441.
•   Au J.T., K. Kayitenkore, E. Shutes, E. Karita, P.J. Peters, A. Tichacek, S.A.
    Allen. 2006. Accessto adequate nutrition is a major potential obstacle to
    antiretroviral adherence among HIVinfected individuals in Rwanda. AIDS
    20 (16): 2116-2118.
Any Questions ?

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Hiv

  • 1. HIV By : Zain al abdeen
  • 2. Outline • Definitions • Presence of HIV/AIDS Worldwide • Diagnosis • Infection • Transmission • Treatment • Nutrition – Treatment
  • 3. Definitions • HIV: Human Immunodeficiency Virus – a retrovirus that targets the CD4 T helper immune cells • AIDS: Acquired Immunodeficiency Syndrome – the final stage of HIV infection
  • 5. Diagnosis of advanced HIV to AIDS • Three Criteria: 1. A CD4+ cell count of less than 200 cells per microliter 2. A CD4+ cell count that comprises of less than 14% lymphocytes present 3. And/or an AIDS defining illness – bacterial infections, wasting syndrome
  • 6. Diagnosis • Screening Tests licensed by the FDA – Test serum or plasma with high sensitivity to HIV type 1 (HIV-1) antibodies • Enzyme-Linked Immunoabsorbent Assay (ELISA) – Confirmatory test • ELISA, Enzyme Immunoassay (EIA), Western blot, modified Western blot, and line immunoassay (LIA) – Combination ELISA testing • Both antigen and antibodies • Earlier diagnosis
  • 8. Infection • New HIV Infections by Age Group
  • 10. Transmission • Through Bodily Fluids : 1- Blood products 2- Vaginal fluids 3- Semen 4- Breast Milk
  • 11. Transmission • Sharing Needles – Without sterilization – 8% • Mother-to-Baby  Before Birth  During Birth  After the birth  Vertical transmission before birth or through breastfeeding = <1%
  • 12. Transmission • Through Sex # Intercourse # Oral sex # Anal sex # Digital Sex • Male-to-male = 54% • Heterosexual = 34%
  • 13. Stages of HIV • Stage 1 • Short, flu-like illness - occurs one to six weeks after infection • no symptoms at all • Infected person can infect other people
  • 14. Stages of HIV • Stage 2 • Lasts for an average of ten years • This stage is free from symptoms • There may be swollen glands • The level of HIV in the blood drops to very low levels • HIV antibodies are detectable in the blood
  • 15. Stages of HIV • Stage 3 • The symptoms are mild • The immune system drop • emergence of infections and cancers
  • 16. Stages of HIV • Stage 4 • The immune system weakens • The illnesses become more severe leading to an AIDS diagnosis
  • 17. Treatment • Antiretroviral Therapies (ART) • Highly active retroviral therapy (HAART) • Aimed at interrupting viral life cycle and decreasing viral load
  • 18. Nutrition – Treatment • Goals: – Preserve body cell mass – Provide adequate amounts of all nutrients for proper function – Minimize the symptoms
  • 19. Nutrition – Treatment • Energy Needs : • Energy – based on need to maintain weight – Harris-Benedict Formula + extra kcal as needed – 20-30% increased energy for recovery from infections • Protein – increased for infection – 1.2 – 1.8 g/kg/day • Females: at least 100 grams of protein per day • Males: at least 125 grams of protein per day
  • 20. Nutrition – Treatment • Reduce Fat : • Fat can be hard for your body to digest when you have HIV diseases , it can cause diarrhea, nausea, gas and bloating
  • 21. Nutrition – Treatment • High Nutrient Foods Yogurt Tuna Beans Leafy Brown Rice Cheese Chicken Lentils Greens Whole Eggs Fish Corn Squash Grains Cottage Yams Cheese Tofu, All Oatmeal All Fruit Peanut Tempeh, Vegetables Wheat Germ Broccoli Butter Soy Nuts Nuts
  • 22. Nutrition – Treatment • Micronutrient Needs • Dietary Reference Intakes – Vitamin A – 700-900 μg/day • Immune function – Vitamin E – 15 mg/day • Immune function – antioxidant protection – Vitamin B12 – 2.4 mcg/day • Cognitive function – Selenium – 55 μg/day • Immune function – antioxidant protection – Zinc – 8-11mg/day • Immune function, slowed disease progression
  • 23. Nutrition – Treatment • Symptom Management – Nausea and Vomiting • Replace fluids and electrolytes • Bland, odorless foods • Beverages between meals • Smaller, more frequent meals • Reduce fatty foods with early satiety
  • 24. Nutrition – Treatment • Symptom Management – Diarrhea • Replace fluids and electrolytes – juice, sports drinks, gelatin • Bland foods low in fiber • Avoid fatty and gassy foods • Avoid lactose if problematic
  • 25. Nutrition – Treatment • Symptom Management – Anorexia • Eat favorite foods often in relaxed settings • Add flavors and an array of colors • Keep snacks handy • Appetite stimulants
  • 26. Nutrition – Treatment • Symptom Management – Oral ,chewing & swallowing problems • Moist, soft, and finely diced foods • Avoid spicy or acid-containing foods • Room temperature or cooler foods • Topical medicines
  • 27. Nutrition – Treatment • Common Deficiencies : • Vitamin A, zinc, iron- detrimental to the immune function • antioxidants- Vit A, Vit. C, and B vitamins can also compromise immune function b/c of their roles as cofactors in many enzyme functions including those involved in nucleic acid synthesis
  • 28. Social strategies • Social strategies do not require any drug or object to be effective , but rather require persons to change their behavior in order to gain protection from HIV • Some social strategies which people consider include the following : • sex education • Safe injection sites • Sexual abstinence
  • 30. REFERENCES • Grinspoon S, Mulligan K. For the Department of Health and Human Services working group on the prevention and treatment of wasting and weight loss. HIV related weight loss and wasting. In Supplement: Integrating nutrition management into HIV medical management.Guest Editor, Celia Hayes. Clinical Infectious Diseases, 2003, • ME Brecher, et al. Is It HIV TTP or HIV-Associated Thrombotic Microangiopathy? J of Clin Apheresis. 2008 • Fawzi, W., Msamanga, G., Spiegelman, D., Hunter, D. (2005). Studies of Vitamins and Minerals and HIV Transmission and Disease Progression. The Journal of Nutrition, 135, 938-944. • Fields-Gardner, Cade, & Fergusson, Pamela. (2004). Position of the American Dietetic Association and Dietitians of Canada: Nutrition Intervention in the care of Persons with Human Immunodeficiency Virus Infection. Journal of The American Dietetic Association, 104(9), 1425- 1441. • Au J.T., K. Kayitenkore, E. Shutes, E. Karita, P.J. Peters, A. Tichacek, S.A. Allen. 2006. Accessto adequate nutrition is a major potential obstacle to antiretroviral adherence among HIVinfected individuals in Rwanda. AIDS 20 (16): 2116-2118.