The document evaluates different cation exchange resins for capturing a recombinant human growth factor directly from a refold solution containing high salt concentrations. Testing showed the new salt tolerant Eshmuno® CPS resin had a two-fold higher binding capacity than other resins when processing the high salt refold solution. Purification trials using the Eshmuno® CPS and Eshmuno® CPX resins achieved similar purity and yield. A cost analysis found using the salt tolerant Eshmuno® CPS resin reduced costs per gram of target produced by 1.9-fold and increased productivity by 50% compared to the standard Eshmuno® CPX resin. Compared to a conventional resin requiring feed dilution, the Eshmuno®