The sodium channel is a channel present on the membrane that allows a small amount of Na+ to enter the cell along its electrochemical gradient, as discovered by British scientists Hodgkin and Huxley. It can be divided into two types, voltage-gated and ligand-gated. The sodium ion channel is the primary activation bond for electrical signals in all animals, while the electrical signal is the basis for a series of physiological processes such as neural activity and muscle contraction.
The sodium channel is a channel present on the membrane that allows a small amount of Na+ to enter the cell along its electrochemical gradient, as discovered by British scientists Hodgkin and Huxley. It can be divided into two types, voltage-gated and ligand-gated. The sodium ion channel is the primary activation bond for electrical signals in all animals, while the electrical signal is the basis for a series of physiological processes such as neural activity and muscle contraction.
Numerous cells are able to ingest foreign materials, but the ability to increase this activity in response to opsonization by antibody and/or complement, so as to acquire antigen specificity, is restricted to cells of the myeloid series, principally polymorphs, monocytes and macrophages; these are sometimes termed ‘professional’ phagocytes.
Neuroscience is characterized by multi-disciplinary and multi-level intersections. It combines behavior, cognition and brain mechanism, and it attempts to elaborate the neural mechanism of human and animal in perceiving objects, forming images, using language, memorizing information, reasoning and decision-making at the micro level of molecule, synapse and neuron and at the macro level of system, whole brain and behavior.
Transient receptor potenital (TRP) is a large family of non-selective cation channels located on the cell membrane. One type of channel can be activated by Vanillic acid compounds, so this type of channel is called the TRPV subfamily. Mutations in TRPV are associated with neurodegenerative diseases, skeletal dysplasia, kidney disease and cancer and TRPV is an important therapeutic target for these diseases.
CFTR is a chloride channel located on the cell membrane. Under the mediation of cAMP, CFTR is phosphorylated, causing the channel to open and transporting about 10 CIs extracellularly per minute. When the cftr gene is mutated (most commonly, the codon encoding 508 phenylalanine is lost), the defective CFTR cannot be processed normally in the endoplasmic reticulum, and most cannot be transported to the cell membrane;
The organic cation transporter (OCT) is an important drug delivery protein with a broad tissue distribution in the body that mediates the metabolic processes of most drugs. At present, the gene sequence, transport mechanism, substrate structure specificity, regulatory mechanism, gene polymorphism andin vivodistribution characteristics of this transporter have been deeply studied. Based on this knowledge, pharmacologists have successfully delivered many drugs at the transporter molecule level and applied them to clinical practice.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. A variety of epigenetic mechanisms can be perturbed in different types of cancer. Epigenetic alterations of DNA repair genes or cell cycle control genes are very frequent in sporadic (non-germ line) cancers, being significantly more common than germ line (familial) mutations in these sporadic cancers.
In genetics, genotoxicity describes the property of chemical agents that damage the genetic information within a cell causing mutations(Genotoxicity is often confused with mutagenicity. All mutagens are genotoxic, whereas not all genotoxic substances are mutagenic.). The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage resulting in mutations.
The process of cell cycle regulation is the activation or inactivation of various regulatory factors under the surveillance of checkpoints, thereby initiating the process of cell DNA replication and division into two daughter cells.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Post-translational modifications play an important role in cells, such as DNA recognition, protein-protein interactions, catalytic activity, and protein stability. Protein acetylation/deacetylation is a histone covalent modification that is mainly catalyzed by histone acetylase and histone deacetylase, respectively.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Mitochondria are a subcellular structure prevalent in eukaryotic cells and the most important source of energy in cells. Most tissue cells in the human body rely on oxidative phosphorylation of mitochondria to obtain the energy needed to maintain their metabolism.
Immunoassay is a biochemical method that identifies and quantifies unknown analytes (protein, lipid, nucleic acid etc.) in solution (serum, urine etc.) using antibody-antigen reactions.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Post-translational modifications play an important role in cells, such as DNA recognition, protein-protein interactions, catalytic activity, and protein stability. Protein acetylation/deacetylation is a histone covalent modification that is mainly catalyzed by histone acetylase and histone deacetylase, respectively.
Immunoassay is a biochemical method that identifies and quantifies unknown analytes (protein, lipid, nucleic acid etc.) in solution (serum, urine etc.) using antibody-antigen reactions.
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices.
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Cytokine proteins are classified as chemokines according to behavior and structural characteristics.
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Cytokine proteins are classified as chemokines according to behavior and structural characteristics.
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Numerous cells are able to ingest foreign materials, but the ability to increase this activity in response to opsonization by antibody and/or complement, so as to acquire antigen specificity, is restricted to cells of the myeloid series, principally polymorphs, monocytes and macrophages; these are sometimes termed ‘professional’ phagocytes.
Neuroscience is characterized by multi-disciplinary and multi-level intersections. It combines behavior, cognition and brain mechanism, and it attempts to elaborate the neural mechanism of human and animal in perceiving objects, forming images, using language, memorizing information, reasoning and decision-making at the micro level of molecule, synapse and neuron and at the macro level of system, whole brain and behavior.
Transient receptor potenital (TRP) is a large family of non-selective cation channels located on the cell membrane. One type of channel can be activated by Vanillic acid compounds, so this type of channel is called the TRPV subfamily. Mutations in TRPV are associated with neurodegenerative diseases, skeletal dysplasia, kidney disease and cancer and TRPV is an important therapeutic target for these diseases.
CFTR is a chloride channel located on the cell membrane. Under the mediation of cAMP, CFTR is phosphorylated, causing the channel to open and transporting about 10 CIs extracellularly per minute. When the cftr gene is mutated (most commonly, the codon encoding 508 phenylalanine is lost), the defective CFTR cannot be processed normally in the endoplasmic reticulum, and most cannot be transported to the cell membrane;
The organic cation transporter (OCT) is an important drug delivery protein with a broad tissue distribution in the body that mediates the metabolic processes of most drugs. At present, the gene sequence, transport mechanism, substrate structure specificity, regulatory mechanism, gene polymorphism andin vivodistribution characteristics of this transporter have been deeply studied. Based on this knowledge, pharmacologists have successfully delivered many drugs at the transporter molecule level and applied them to clinical practice.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. A variety of epigenetic mechanisms can be perturbed in different types of cancer. Epigenetic alterations of DNA repair genes or cell cycle control genes are very frequent in sporadic (non-germ line) cancers, being significantly more common than germ line (familial) mutations in these sporadic cancers.
In genetics, genotoxicity describes the property of chemical agents that damage the genetic information within a cell causing mutations(Genotoxicity is often confused with mutagenicity. All mutagens are genotoxic, whereas not all genotoxic substances are mutagenic.). The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage resulting in mutations.
The process of cell cycle regulation is the activation or inactivation of various regulatory factors under the surveillance of checkpoints, thereby initiating the process of cell DNA replication and division into two daughter cells.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Post-translational modifications play an important role in cells, such as DNA recognition, protein-protein interactions, catalytic activity, and protein stability. Protein acetylation/deacetylation is a histone covalent modification that is mainly catalyzed by histone acetylase and histone deacetylase, respectively.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Mitochondria are a subcellular structure prevalent in eukaryotic cells and the most important source of energy in cells. Most tissue cells in the human body rely on oxidative phosphorylation of mitochondria to obtain the energy needed to maintain their metabolism.
Immunoassay is a biochemical method that identifies and quantifies unknown analytes (protein, lipid, nucleic acid etc.) in solution (serum, urine etc.) using antibody-antigen reactions.
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis.
Post-translational modifications play an important role in cells, such as DNA recognition, protein-protein interactions, catalytic activity, and protein stability. Protein acetylation/deacetylation is a histone covalent modification that is mainly catalyzed by histone acetylase and histone deacetylase, respectively.
Immunoassay is a biochemical method that identifies and quantifies unknown analytes (protein, lipid, nucleic acid etc.) in solution (serum, urine etc.) using antibody-antigen reactions.
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices.
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Cytokine proteins are classified as chemokines according to behavior and structural characteristics.
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Cytokine proteins are classified as chemokines according to behavior and structural characteristics.
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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