The article analyzes the cost-effectiveness of a potential national rotavirus immunization program in the United States. It uses decision analysis to estimate the economic impacts and determine if such a program would be beneficial. The analysis considers costs such as physician visits, hospitalizations, and lost productivity due to rotavirus infections, and compares these to the costs of implementing a vaccination program. The conclusions will help inform healthcare policy by indicating whether a rotavirus immunization program should be adopted on a national level.