This chapter discusses ethics related to dealing with life-threatening and incurable diseases. It addresses issues such as a patient's right to refuse treatment, stopping medical treatment, cardiopulmonary resuscitation (CPR), and conditions of prolonged or terminal coma. Key points include that patients have the right to refuse treatment if fully informed, treatment should not be stopped if the patient and family disagree, CPR may not be useful in late-stage or incurable diseases, and patients in irreversible coma should continue receiving care without complicated equipment. All decisions must be well-documented and communicated to the treatment team and patient's family.