This research article discusses the lateral transfer of group I introns between red and brown algae. The researchers found that a group I intron inserted at position 516 in the small subunit rRNA contained a unique helical insertion in the P5b helix in both bangiophyte red algae and the brown alga Aureoumbra lagunensis, though the host cells are evolutionarily distant. They analyzed the secondary structure and phylogeny of these introns to understand their origin. The highly conserved structure of the insertion suggests it is important functionally, though its specific role is unknown. Their analyses support the scenario that the intron was laterally transferred between red and brown algae after their divergence, rather than being present in
The document lists 20 facts about the human genome. It notes that the genome contains the complete set of instructions to make a human, encoded in DNA's four letters - A, C, G, and T. It also explains that there are 3 billion letters in the genome of every cell, and if stretched end to end the DNA from all cells would reach to the sun and back over 600 times. Additionally, it states that while humans share 98% of DNA with chimpanzees, the differences between any two humans is only around 0.2%.
Howdy! This is a fantastic biology literature review example that we've prepared for you. If you need more go to https://www.literaturereviewwritingservice.com/biology-literature-review-example-and-writing-tips/
An accurate distance_to_the_nearest_galaxySérgio Sacani
This document summarizes recent research that more accurately measured the distance to the Large Magellanic Cloud (LMC) galaxy. A team called the Araucaria Project measured the distances to eight eclipsing binary stars in the LMC to determine a distance of 49.3 ± 0.5 kiloparsecs, which is accurate to 2.2%. This more precise measurement of the distance to the LMC will help astronomers better determine distances to more distant galaxies and improve our understanding of properties like dark energy. The new measurement is consistent with but more accurate than previous estimates, addressing issues with prior discrepancies in LMC distance measurements.
This document discusses evidence of lateral transfer of a group IE intron between fungal and red algal small subunit rRNA genes. It finds that a group IE intron inserted at position 989 in the nuclear SSU rRNA gene of the red alga Hildenbrandia rubra is closely related to similar fungal IE introns, providing evidence the intron was laterally transferred rather than vertically inherited. Phylogenetic analysis of intron sequences and comparisons of intron secondary structures support a relationship between the red algal intron and fungal introns, making lateral transfer the most likely explanation for the intron's presence in H. rubra.
American Gut Project presentation at Masaryk Universitymcdonadt
The document discusses the microbiome and how microbes outnumber human cells in the human body. It provides several references from scientific studies published between 2001-2015 that examine the microbiome composition in different human and environmental populations using genetic sequencing and analysis techniques. It also discusses challenges and variations in microbiome analysis methods and highlights some key researchers and projects investigating the human microbiome.
1) The transcription factor Dip3 is expressed in all photoreceptor cells in the developing Drosophila eye.
2) Loss of Dip3 leads to the formation of an extra photoreceptor in many ommatidia.
3) Ectopic expression of Dip3 in non-neuronal cells inhibits photoreceptor formation, leading to a loss of photoreceptors.
This research article discusses the lateral transfer of group I introns between red and brown algae. The researchers found that a group I intron inserted at position 516 in the small subunit rRNA contained a unique helical insertion in the P5b helix in both bangiophyte red algae and the brown alga Aureoumbra lagunensis, though the host cells are evolutionarily distant. They analyzed the secondary structure and phylogeny of these introns to understand their origin. The highly conserved structure of the insertion suggests it is important functionally, though its specific role is unknown. Their analyses support the scenario that the intron was laterally transferred between red and brown algae after their divergence, rather than being present in
The document lists 20 facts about the human genome. It notes that the genome contains the complete set of instructions to make a human, encoded in DNA's four letters - A, C, G, and T. It also explains that there are 3 billion letters in the genome of every cell, and if stretched end to end the DNA from all cells would reach to the sun and back over 600 times. Additionally, it states that while humans share 98% of DNA with chimpanzees, the differences between any two humans is only around 0.2%.
Howdy! This is a fantastic biology literature review example that we've prepared for you. If you need more go to https://www.literaturereviewwritingservice.com/biology-literature-review-example-and-writing-tips/
An accurate distance_to_the_nearest_galaxySérgio Sacani
This document summarizes recent research that more accurately measured the distance to the Large Magellanic Cloud (LMC) galaxy. A team called the Araucaria Project measured the distances to eight eclipsing binary stars in the LMC to determine a distance of 49.3 ± 0.5 kiloparsecs, which is accurate to 2.2%. This more precise measurement of the distance to the LMC will help astronomers better determine distances to more distant galaxies and improve our understanding of properties like dark energy. The new measurement is consistent with but more accurate than previous estimates, addressing issues with prior discrepancies in LMC distance measurements.
This document discusses evidence of lateral transfer of a group IE intron between fungal and red algal small subunit rRNA genes. It finds that a group IE intron inserted at position 989 in the nuclear SSU rRNA gene of the red alga Hildenbrandia rubra is closely related to similar fungal IE introns, providing evidence the intron was laterally transferred rather than vertically inherited. Phylogenetic analysis of intron sequences and comparisons of intron secondary structures support a relationship between the red algal intron and fungal introns, making lateral transfer the most likely explanation for the intron's presence in H. rubra.
American Gut Project presentation at Masaryk Universitymcdonadt
The document discusses the microbiome and how microbes outnumber human cells in the human body. It provides several references from scientific studies published between 2001-2015 that examine the microbiome composition in different human and environmental populations using genetic sequencing and analysis techniques. It also discusses challenges and variations in microbiome analysis methods and highlights some key researchers and projects investigating the human microbiome.
1) The transcription factor Dip3 is expressed in all photoreceptor cells in the developing Drosophila eye.
2) Loss of Dip3 leads to the formation of an extra photoreceptor in many ommatidia.
3) Ectopic expression of Dip3 in non-neuronal cells inhibits photoreceptor formation, leading to a loss of photoreceptors.
The document summarizes the identification of six hemocyte cell types in Culex quinquefasciatus by light and transmission electron microscopy:
1) Prohemocytes, the smallest hemocytes, with a large central nucleus and few organelles. They represent 9.3% of hemocytes.
2) Spherulocytes, small hemocytes with numerous spherules containing a lamellar pattern and dense core. They are 1.6% of hemocytes.
3) Adipohemocytes, rare cells with a large nucleolated nucleus, cytoplasm containing organelles and lipid inclusions. They are 0.8% of hemocytes.
4) Oenocytoids
Phage adhere more strongly to mucus layers than surrounding environments across diverse animal species. In vitro experiments show that phage adhere specifically to mucin glycoproteins in mucus via interactions between Ig-like domains on phage capsids and glycan residues on mucins. Pretreating mucus-producing cells with phage reduces subsequent bacterial attachment and infection, protecting the underlying epithelium. The presence of Ig-like protein domains in phages from many environments suggests a widespread symbiotic relationship between phages and metazoans, whereby phage adherence to mucus provides a non-host-derived antimicrobial defense of mucosal surfaces.
This document discusses a study that found molecular and morphological evidence suggesting that the flagellate Ancyromonas is closely related to the common ancestor of metazoans, fungi, and choanoflagellates. Analyses of 18S rRNA gene sequences from major eukaryotic lineages using maximum likelihood, minimum evolution, and maximum parsimony supported Ancyromonas forming its own lineage, called Ancyromonadida, that is more closely related to opisthokonts than its nearest protist relatives. However, low bootstrap support for deep nodes limits the ability of 18S rDNA to fully resolve this aspect of eukaryotic phylogeny.
This study examines the impact of low-shear modeled microgravity (LSMMG) on the virulence of Serratia marcescens bacteria in fruit flies (Drosophila melanogaster). S. marcescens will be grown in a Rotating Wall Vessel to simulate microgravity and injected into fruit flies. Survival of the flies will then be monitored over time along with bacterial load to determine if microgravity alters the virulence of S. marcescens. Mutant fruit fly lines with impaired immune systems will also be used to mimic the weakened immunity in microgravity. This project aims to further understand host-pathogen interactions under altered gravity conditions.
1. Frederick Griffith conducted an experiment in 1928 that showed a "transforming principle" in bacteria, demonstrating that genetic information could be transferred between bacterial strains.
2. He found that mice injected with a mixture of dead, heat-killed bacteria and live bacteria died, and the bacteria in their blood showed a transformation from the normally harmless strain to the deadly strain.
3. This established that some kind of genetic information was being transferred, pioneering the discovery of DNA as the mechanism of inheritance over 30 years later.
HRV-1A infection fragments the Golgi apparatus and redistributes Golgi membranes into vesicles approximately 250-500nm in diameter. These Golgi-derived vesicles colocalize with viral RNA replication templates, indicating they serve as sites of viral RNA replication. Expression of the HRV-1A 3A protein alone is sufficient to induce Golgi fragmentation similar to infection and the 3A protein localizes to the Golgi-derived membranes, suggesting it plays a role in Golgi fragmentation to generate membranes for viral replication.
Genetic differentiation of Artemia feanciscana in Kenyan coastal saltworksErick Ogello
This document summarizes a study that analyzed the genetic differentiation between the native Artemia franciscana population from San Francisco Bay, USA and introduced populations in Kenyan coastal saltworks using molecular markers. Analysis of mitochondrial DNA and heat shock protein 70 gene sequences found evidence of genetic differentiation and haplotype diversity between populations, indicating evolutionary changes have occurred since introduction. Specifically, a private haplotype was found in samples from Fundisha saltworks, providing molecular evidence of genetic differentiation between populations, though not at a statistically significant level. The heat shock protein 70 gene sequences did not show unique signatures between Kenyan and source populations, suggesting other factors contribute to their increased thermotolerance. Further genetic study using larger DNA fragments was recommended
Phylogeny-Driven Approaches to Genomics and Metagenomics - talk by Jonathan E...Jonathan Eisen
This document summarizes Jonathan Eisen's talk at Fresno State University about phylogeny-driven approaches to genomics and metagenomics. The talk focused on 3 main topics:
1) Eisen's early career work using rRNA phylogeny to study microbial diversity and evolution, including his work on halophiles and using rRNA to study microbes in the environment.
2) The revolution brought about by using high-throughput sequencing of rRNA genes (phylotyping) to deeply characterize microbial communities from various environments and uncover the rare biosphere.
3) How next-generation sequencing has further expanded the field by allowing more samples to be analyzed at a finer scale, revealing patterns of beta-diversity across spatial
"Estimation of Divergence Times in Asparagales in the Presence of Hybridization," presented in symposium "Insights and Benefits from Monocot Palaeobiology: Fossils, DNA, and Phylogenies" at Monocots V (5th International Conference on Comparative Biology of Monocotyledons, The New York Botanical Garden, July 2013).
Comparative analysis of genome sequences from six strains of Streptococcus agalactiae (Group B Streptococcus; GBS), representing the five major disease-causing serotypes, and two previously sequenced genomes suggests that a bacterial species can be described by its "pan-genome". The pan-genome includes a core genome of genes present in all strains and a dispensable genome of strain-specific and partially shared genes. While 80% of any single genome is shared among all isolates (core genome), sequencing additional strains revealed unique genes, and extrapolation predicts more unique genes will be found with further sequencing. Multiple independent genome sequences are thus required to fully understand the genomic complexity of a bacterial species.
Science 2013-schuenemann-179-83 leprosy önemliHazal Sav
This study obtained near-complete genome sequences of Mycobacterium leprae from skeletal remains dating from the 11th to 14th centuries in Europe, as well as from recent patient biopsies. Genome comparisons revealed remarkable genomic conservation of M. leprae over the past 1000 years. The ancient genomes suggest a European origin for leprosy in the Americas and the presence of a genotype in medieval Europe now commonly associated with the Middle East. Exceptional DNA and mycolic acid preservation in the ancient skeletal remains provides insights into pathogen evolution and the disappearance of leprosy in Europe.
This document summarizes a study that characterized the ecdysone receptor (EcR) gene in the salmon louse (Lepeophtheirus salmonis), an economically important parasite in salmon farming. The researchers isolated and sequenced cDNA of the predicted L. salmonis EcR gene, which encoded a protein highly similar to other arthropod EcRs. In situ analysis showed the EcR transcript is expressed in ovaries, sub-cuticle, and oocytes of adult female lice. Knockdown of EcR using RNA interference terminated egg production, indicating it plays an important role in reproduction and oocyte maturation. This suggests disrupting EcR signaling may provide a way to control louse reproduction and infestation.
UC Davis EVE161 Lecture 18 by @phylogenomicsJonathan Eisen
This document contains slides for a lecture on metagenomics. It discusses student presentation guidelines, summarizes a published article on characterizing genes from the human gut microbiome, provides details on the methods used in that study to extract and sequence DNA from fecal samples of 124 individuals, and includes some results tables. The study generated over 500 GB of sequence data and identified over 3 million non-redundant microbial genes from the gut microbiome.
This document discusses Pavel Pevzner's research on genome rearrangements from an evolutionary perspective. It explores three main evolutionary controversies: 1) the divergence order of primates, rodents, and carnivores, 2) the existence of rearrangement hotspots in genomes, and 3) whether whole genome duplications occurred in early eukaryotic evolution. For each controversy, the document outlines the opposing views, evidence presented by various studies over time, and how the debates were ultimately resolved (or not resolved in some cases).
This document analyzes spliceosomal introns in ribosomal RNA genes of fungi. The key findings are:
1) Analysis of 49 intron insertion sites in fungal rRNA genes found that the conserved flanking sequence is G-intron-G, suggesting this is the proto-splice site where introns are inserted.
2) The exon sequences flanking the introns contain statistically significant information content, indicating the presence of potential regulatory elements.
3) Spliceosomal introns in fungal rRNA genes tend to occur in less conserved regions of the rRNA, whereas group I introns occur in more functionally important, conserved regions.
This document discusses various methods for measuring genetic selection in genomes. It examines comparing rates of synonymous and non-synonymous mutations to identify regions under negative or positive selection. Another method looks for extremely conserved elements or rapidly evolving regions across species. Analyzing population variation data through measures like Tajima's D or GWAS can also reveal selective sweeps. Transposon-free and INDEL-free regions may also indicate genetic selection.
This document summarizes information about feline coronavirus (FCoV) which causes feline infectious peritonitis (FIP). It discusses that FCoV exists as two biotypes - feline enteric coronavirus (FECV) which causes a mild enteric infection, and feline infectious peritonitis virus (FIPV) which causes a lethal systemic infection. The viral structure and proteins like the nucleocapsid, membrane, spike, and envelope proteins are described. It also covers FCoV taxonomy, genetics, serotypes, and the theories around how FECV may mutate to the virulent FIPV form.
Investigation of the localization and phenotypic effects of the mRNA transpor...Amanda Estes
This study aimed to determine the localization of the mRNA transport protein She3 in Candida albicans and examine the phenotypic effects of deleting the SHE3 gene. GFP was tagged to She3 to visualize its localization using fluorescence microscopy. One strain exhibited potential nuclear localization of She3-GFP. Western blot detected a faint band for She3-GFP, suggesting it was expressed. Deletion of SHE3 affected filamentation on certain media but not lipase production, indicating She3 influences some virulence factors in C. albicans.
The document summarizes research on retinal stem cells in the Japanese rice fish model. Researchers transplanted fluorescent protein-labeled retinal stem cells into host blastulae and observed that the stem cells gave rise to all three major retinal layers, indicating their multipotency. Further experiments using multicolor transgenic fish lines confirmed that arched continuous stripes in the retina arose from single retinal stem cells. Additional work showed that post-embryonic retinal stem cells also retained multipotency and could generate all retinal cell types, demonstrating that developmental progression does not affect this potential of retinal stem cells. The researchers concluded that retinal stem cells are multipotent and can develop into all neural retina layers throughout development.
Lectut btn-202-ppt-l2. introduction and historical background part ii (1)Rishabh Jain
This document provides a historical timeline of major developments in genetics and genomics from 1985 to 2008. It describes 33 key events, including the development of DNA fingerprinting in 1985, the polymerase chain reaction in 1986, the first human gene therapy trial in 1990, the publication of the first draft of the human genome in 2001, and the first synthetic bacterial genome in 2008. Many important milestones are highlighted, such as the sequencing of the first free-living organism in 1995, the introduction of RNAi in 1998, and James Watson becoming the first person to receive his personal genome sequence in 2007.
This document describes a study that analyzed the mitochondrial large subunit ribosomal RNA (LSU rRNA) sequences and secondary structures of 10 mollusk species. The researchers determined the complete nucleotide sequences and inferred the secondary structure models for each species. They found substantial length variation among taxa, with gastropods having the shortest lengths. Phylogenetic analysis supported monophyly of several taxa. Most notably, they discovered phylogenetic signal in the secondary structure of mollusk rRNA, with some gastropods uniquely lacking stem/loop structures, explaining much of the observed length variation.
This document presents a secondary structural model of expansion segments D2 and D3 from the 28S rRNA gene of 229 leaf beetles (Coleoptera: Chrysomelidae), most of which are in the subfamily Galerucinae. The model is based on a multiple sequence alignment that was analyzed to infer secondary structure based on compensatory base changes. The model consists of seven major compound helices and delineates conserved regions that can be confidently aligned versus regions of alignment ambiguity. This structural model of the D2 and D3 expansion segments will aid in assigning positional nucleotide homology and phylogenetic reconstruction for these and related beetle taxa.
The document summarizes the identification of six hemocyte cell types in Culex quinquefasciatus by light and transmission electron microscopy:
1) Prohemocytes, the smallest hemocytes, with a large central nucleus and few organelles. They represent 9.3% of hemocytes.
2) Spherulocytes, small hemocytes with numerous spherules containing a lamellar pattern and dense core. They are 1.6% of hemocytes.
3) Adipohemocytes, rare cells with a large nucleolated nucleus, cytoplasm containing organelles and lipid inclusions. They are 0.8% of hemocytes.
4) Oenocytoids
Phage adhere more strongly to mucus layers than surrounding environments across diverse animal species. In vitro experiments show that phage adhere specifically to mucin glycoproteins in mucus via interactions between Ig-like domains on phage capsids and glycan residues on mucins. Pretreating mucus-producing cells with phage reduces subsequent bacterial attachment and infection, protecting the underlying epithelium. The presence of Ig-like protein domains in phages from many environments suggests a widespread symbiotic relationship between phages and metazoans, whereby phage adherence to mucus provides a non-host-derived antimicrobial defense of mucosal surfaces.
This document discusses a study that found molecular and morphological evidence suggesting that the flagellate Ancyromonas is closely related to the common ancestor of metazoans, fungi, and choanoflagellates. Analyses of 18S rRNA gene sequences from major eukaryotic lineages using maximum likelihood, minimum evolution, and maximum parsimony supported Ancyromonas forming its own lineage, called Ancyromonadida, that is more closely related to opisthokonts than its nearest protist relatives. However, low bootstrap support for deep nodes limits the ability of 18S rDNA to fully resolve this aspect of eukaryotic phylogeny.
This study examines the impact of low-shear modeled microgravity (LSMMG) on the virulence of Serratia marcescens bacteria in fruit flies (Drosophila melanogaster). S. marcescens will be grown in a Rotating Wall Vessel to simulate microgravity and injected into fruit flies. Survival of the flies will then be monitored over time along with bacterial load to determine if microgravity alters the virulence of S. marcescens. Mutant fruit fly lines with impaired immune systems will also be used to mimic the weakened immunity in microgravity. This project aims to further understand host-pathogen interactions under altered gravity conditions.
1. Frederick Griffith conducted an experiment in 1928 that showed a "transforming principle" in bacteria, demonstrating that genetic information could be transferred between bacterial strains.
2. He found that mice injected with a mixture of dead, heat-killed bacteria and live bacteria died, and the bacteria in their blood showed a transformation from the normally harmless strain to the deadly strain.
3. This established that some kind of genetic information was being transferred, pioneering the discovery of DNA as the mechanism of inheritance over 30 years later.
HRV-1A infection fragments the Golgi apparatus and redistributes Golgi membranes into vesicles approximately 250-500nm in diameter. These Golgi-derived vesicles colocalize with viral RNA replication templates, indicating they serve as sites of viral RNA replication. Expression of the HRV-1A 3A protein alone is sufficient to induce Golgi fragmentation similar to infection and the 3A protein localizes to the Golgi-derived membranes, suggesting it plays a role in Golgi fragmentation to generate membranes for viral replication.
Genetic differentiation of Artemia feanciscana in Kenyan coastal saltworksErick Ogello
This document summarizes a study that analyzed the genetic differentiation between the native Artemia franciscana population from San Francisco Bay, USA and introduced populations in Kenyan coastal saltworks using molecular markers. Analysis of mitochondrial DNA and heat shock protein 70 gene sequences found evidence of genetic differentiation and haplotype diversity between populations, indicating evolutionary changes have occurred since introduction. Specifically, a private haplotype was found in samples from Fundisha saltworks, providing molecular evidence of genetic differentiation between populations, though not at a statistically significant level. The heat shock protein 70 gene sequences did not show unique signatures between Kenyan and source populations, suggesting other factors contribute to their increased thermotolerance. Further genetic study using larger DNA fragments was recommended
Phylogeny-Driven Approaches to Genomics and Metagenomics - talk by Jonathan E...Jonathan Eisen
This document summarizes Jonathan Eisen's talk at Fresno State University about phylogeny-driven approaches to genomics and metagenomics. The talk focused on 3 main topics:
1) Eisen's early career work using rRNA phylogeny to study microbial diversity and evolution, including his work on halophiles and using rRNA to study microbes in the environment.
2) The revolution brought about by using high-throughput sequencing of rRNA genes (phylotyping) to deeply characterize microbial communities from various environments and uncover the rare biosphere.
3) How next-generation sequencing has further expanded the field by allowing more samples to be analyzed at a finer scale, revealing patterns of beta-diversity across spatial
"Estimation of Divergence Times in Asparagales in the Presence of Hybridization," presented in symposium "Insights and Benefits from Monocot Palaeobiology: Fossils, DNA, and Phylogenies" at Monocots V (5th International Conference on Comparative Biology of Monocotyledons, The New York Botanical Garden, July 2013).
Comparative analysis of genome sequences from six strains of Streptococcus agalactiae (Group B Streptococcus; GBS), representing the five major disease-causing serotypes, and two previously sequenced genomes suggests that a bacterial species can be described by its "pan-genome". The pan-genome includes a core genome of genes present in all strains and a dispensable genome of strain-specific and partially shared genes. While 80% of any single genome is shared among all isolates (core genome), sequencing additional strains revealed unique genes, and extrapolation predicts more unique genes will be found with further sequencing. Multiple independent genome sequences are thus required to fully understand the genomic complexity of a bacterial species.
Science 2013-schuenemann-179-83 leprosy önemliHazal Sav
This study obtained near-complete genome sequences of Mycobacterium leprae from skeletal remains dating from the 11th to 14th centuries in Europe, as well as from recent patient biopsies. Genome comparisons revealed remarkable genomic conservation of M. leprae over the past 1000 years. The ancient genomes suggest a European origin for leprosy in the Americas and the presence of a genotype in medieval Europe now commonly associated with the Middle East. Exceptional DNA and mycolic acid preservation in the ancient skeletal remains provides insights into pathogen evolution and the disappearance of leprosy in Europe.
This document summarizes a study that characterized the ecdysone receptor (EcR) gene in the salmon louse (Lepeophtheirus salmonis), an economically important parasite in salmon farming. The researchers isolated and sequenced cDNA of the predicted L. salmonis EcR gene, which encoded a protein highly similar to other arthropod EcRs. In situ analysis showed the EcR transcript is expressed in ovaries, sub-cuticle, and oocytes of adult female lice. Knockdown of EcR using RNA interference terminated egg production, indicating it plays an important role in reproduction and oocyte maturation. This suggests disrupting EcR signaling may provide a way to control louse reproduction and infestation.
UC Davis EVE161 Lecture 18 by @phylogenomicsJonathan Eisen
This document contains slides for a lecture on metagenomics. It discusses student presentation guidelines, summarizes a published article on characterizing genes from the human gut microbiome, provides details on the methods used in that study to extract and sequence DNA from fecal samples of 124 individuals, and includes some results tables. The study generated over 500 GB of sequence data and identified over 3 million non-redundant microbial genes from the gut microbiome.
This document discusses Pavel Pevzner's research on genome rearrangements from an evolutionary perspective. It explores three main evolutionary controversies: 1) the divergence order of primates, rodents, and carnivores, 2) the existence of rearrangement hotspots in genomes, and 3) whether whole genome duplications occurred in early eukaryotic evolution. For each controversy, the document outlines the opposing views, evidence presented by various studies over time, and how the debates were ultimately resolved (or not resolved in some cases).
This document analyzes spliceosomal introns in ribosomal RNA genes of fungi. The key findings are:
1) Analysis of 49 intron insertion sites in fungal rRNA genes found that the conserved flanking sequence is G-intron-G, suggesting this is the proto-splice site where introns are inserted.
2) The exon sequences flanking the introns contain statistically significant information content, indicating the presence of potential regulatory elements.
3) Spliceosomal introns in fungal rRNA genes tend to occur in less conserved regions of the rRNA, whereas group I introns occur in more functionally important, conserved regions.
This document discusses various methods for measuring genetic selection in genomes. It examines comparing rates of synonymous and non-synonymous mutations to identify regions under negative or positive selection. Another method looks for extremely conserved elements or rapidly evolving regions across species. Analyzing population variation data through measures like Tajima's D or GWAS can also reveal selective sweeps. Transposon-free and INDEL-free regions may also indicate genetic selection.
This document summarizes information about feline coronavirus (FCoV) which causes feline infectious peritonitis (FIP). It discusses that FCoV exists as two biotypes - feline enteric coronavirus (FECV) which causes a mild enteric infection, and feline infectious peritonitis virus (FIPV) which causes a lethal systemic infection. The viral structure and proteins like the nucleocapsid, membrane, spike, and envelope proteins are described. It also covers FCoV taxonomy, genetics, serotypes, and the theories around how FECV may mutate to the virulent FIPV form.
Investigation of the localization and phenotypic effects of the mRNA transpor...Amanda Estes
This study aimed to determine the localization of the mRNA transport protein She3 in Candida albicans and examine the phenotypic effects of deleting the SHE3 gene. GFP was tagged to She3 to visualize its localization using fluorescence microscopy. One strain exhibited potential nuclear localization of She3-GFP. Western blot detected a faint band for She3-GFP, suggesting it was expressed. Deletion of SHE3 affected filamentation on certain media but not lipase production, indicating She3 influences some virulence factors in C. albicans.
The document summarizes research on retinal stem cells in the Japanese rice fish model. Researchers transplanted fluorescent protein-labeled retinal stem cells into host blastulae and observed that the stem cells gave rise to all three major retinal layers, indicating their multipotency. Further experiments using multicolor transgenic fish lines confirmed that arched continuous stripes in the retina arose from single retinal stem cells. Additional work showed that post-embryonic retinal stem cells also retained multipotency and could generate all retinal cell types, demonstrating that developmental progression does not affect this potential of retinal stem cells. The researchers concluded that retinal stem cells are multipotent and can develop into all neural retina layers throughout development.
Lectut btn-202-ppt-l2. introduction and historical background part ii (1)Rishabh Jain
This document provides a historical timeline of major developments in genetics and genomics from 1985 to 2008. It describes 33 key events, including the development of DNA fingerprinting in 1985, the polymerase chain reaction in 1986, the first human gene therapy trial in 1990, the publication of the first draft of the human genome in 2001, and the first synthetic bacterial genome in 2008. Many important milestones are highlighted, such as the sequencing of the first free-living organism in 1995, the introduction of RNAi in 1998, and James Watson becoming the first person to receive his personal genome sequence in 2007.
This document describes a study that analyzed the mitochondrial large subunit ribosomal RNA (LSU rRNA) sequences and secondary structures of 10 mollusk species. The researchers determined the complete nucleotide sequences and inferred the secondary structure models for each species. They found substantial length variation among taxa, with gastropods having the shortest lengths. Phylogenetic analysis supported monophyly of several taxa. Most notably, they discovered phylogenetic signal in the secondary structure of mollusk rRNA, with some gastropods uniquely lacking stem/loop structures, explaining much of the observed length variation.
This document presents a secondary structural model of expansion segments D2 and D3 from the 28S rRNA gene of 229 leaf beetles (Coleoptera: Chrysomelidae), most of which are in the subfamily Galerucinae. The model is based on a multiple sequence alignment that was analyzed to infer secondary structure based on compensatory base changes. The model consists of seven major compound helices and delineates conserved regions that can be confidently aligned versus regions of alignment ambiguity. This structural model of the D2 and D3 expansion segments will aid in assigning positional nucleotide homology and phylogenetic reconstruction for these and related beetle taxa.
Gillespie J.J., Johnston J.S., Cannone J.J., and Gutell R.R. (2006).
Characteristics of the nuclear (18S, 5.8S, 28S and 5S) and mitochondrial (12S and 16S) rRNA genes of Apis mellifera (Insecta:Hymenoptera): structure, organization, and retrotransposable elements.
Insect Molecular Biology, 15(5):657-686.
This document proposes establishing a new order, Thoreales, for the freshwater red algal family Thoreaceae based on phylogenetic and ultrastructural evidence. The study examines specimens of Nemalionopsis and Thorea using gene sequencing and electron microscopy of pit plugs. Phylogenetic trees produced from rbcL and 18S rRNA gene sequences strongly support Thoreaceae as a distinct clade separate from other families in the order Batrachospermales. Pit plug ultrastructure also differs from descriptions in Batrachospermales by having two cap layers, with the outer layer usually plate-like. The evidence indicates Thoreaceae has been misclassified in Batrachospermales and warrants being placed in its own order,
The document presents a secondary structure model for the internal transcribed spacer (ITS) regions of nuclear ribosomal DNA in the plant family Asteraceae, based on comparative analysis of 340 ITS sequences. The model identifies helices and other structural motifs in ITS1 and ITS2 that are supported by patterns of covariation between nucleotide positions. The structure-based alignment allows for phylogenetic analysis, resolving relationships among major lineages of Asteraceae. The well-supported tree shows congruence with chloroplast-based phylogenies. The structural model and family-level phylogeny provide new insights into molecular evolution of ITS regions in angiosperms.
This document discusses a new whole-genome based method for constructing phylogenetic trees of prokaryotes without sequence alignment. The method involves using the frequency distribution of k-tuples in complete proteomes to define compositional vectors for each species, and calculating distances between vectors to build trees. Tests recovered accepted relationships from rRNA trees and Bergey's Manual. The approach avoids issues with aligning whole genomes and is independent of genome size and gene content.
photo of moss by Angie Jane Gray (1).pdfFamilyGray1
This study analyzed phylogenetic relationships within the class Sphagnopsida (peat mosses) using nucleotide sequences from the nuclear, plastid, and mitochondrial genomes. The results resolved three lineages within the Sphagnopsida: 1) Sphagnum sericeum, 2) S. inretortum plus Ambuchanania leucobryoides, and 3) all remaining species of Sphagnum. While sister relationships among these three clades could not be determined, the results indicate that the divergent morphology of A. leucobryoides is derived rather than ancestral. Based on these findings, a new classification of the Sphagnopsida is proposed with one order, three families,
The document summarizes a proposed study that aims to investigate convergent evolution of wing morphologies in birds and bats at the molecular level. The study involves using CRISPR/Cas9 gene editing to knockout genes in the BMP pathway (Bmp3) and sonic hedgehog (Shh) pathway in bat and chicken embryos. The expected results are that knockout of Bmp3 will result in shorter forelimbs and wingspans, and knockout of Shh will result in increased bone size and density in the ulna bone of both bats and chickens, supporting the hypothesis that convergent traits evolved through shared genetic mechanisms. Possible complications involve incomplete gene knockout or upregulation of other genes compensating for the knockout.
This document presents a detailed analysis of the secondary structure of 16S ribosomal RNA (rRNA) based on comparative sequence analysis. It finds that 16S rRNA can be broken down into several domains of double-helical elements supported by comparative data showing conserved base pairing across species. The first part reviews evidence for each individual helical element. It presents extensive comparative evidence for conserved base pairing within helices. It also characterizes the phylogenetic conservation and variability of sequences forming each helix. This analysis provides strong support for the secondary structure model of 16S rRNA.
This document discusses evidence for higher order structure in ribosomal RNA. The authors analyze sequences of 16S rRNA from various organisms and find evidence of a Watson-Crick base pair interaction between positions 570 and 866. They test this proposed interaction using sequences from phylogenetically independent organisms and find that it is consistently supported. While this interaction is proven, the exact stereochemistry involved is still uncertain due to complex potential interactions in this region. The authors emphasize that only interactions strongly supported by comparative sequence analysis should be proposed as representing true higher order structure.
The study cloned and analyzed the GJB6 gene, which encodes the connexin 30 protein, from 16 bat species and 4 other mammals. Analysis showed purifying selection on GJB6 in mammals generally, maintaining its important role in hearing. One amino acid substitution was unique to bats, and 10 were shared among artiodactyls. The cytoplasmic loop and carboxy terminus were more variable than other domains in all mammals. The results demonstrate evolutionary conservation of GJB6 in mammals but also lineage-specific rapid evolution in some domains.
This presentation contains basic information about the mouse being used as a model organism, its genome, how the genome of the mouse was sequenced and a comparison between mouse genome and human genome.
This document summarizes the Comparative RNA Web (CRW) Site, an online database that provides comparative sequence and structure information for ribosomal RNAs, transfer RNA, and other RNAs. The CRW Site contains:
1) Current comparative structure models for rRNA and other RNAs derived from extensive sequence analysis and alignment.
2) Nucleotide frequency and conservation data mapped onto phylogenetic trees to show variation and conservation across organisms.
3) A collection of RNA sequences and secondary structure models from diverse organisms.
4) Tools for accessing and searching the database of RNA sequences, structures, and associated metadata.
This study analyzed DNA sequences from nine genes (three plastid, three mitochondrial, and three nuclear) from 100 plant species to better understand relationships among basal angiosperms. Phylogenetic analyses strongly supported Amborella, Nymphaeaceae, and Austrobaileyales as the earliest diverging lineages of flowering plants. The analyses also supported magnoliids as a monophyletic group consisting of Magnoliales, Laurales, Piperales, and Canellales. However, relationships among Ceratophyllum, Chloranthaceae, magnoliids, monocots, and eudicots were mostly unresolved with low support. Examination of substitution patterns supported placement of Amborella and others
This document describes a study comparing the phylogenetic relationships of green algal taxa from the order Chlamydomonadales based on analysis of sequences from the small subunit ribosomal RNA gene in the nucleus and the large subunit ribosomal RNA gene in the chloroplast. The results from both data sets show considerable congruence and support six distinct lineages within Chlamydomonadales that include taxa from the biflagellate genus Chlamydomonas as well as a basal lineage containing quadriflagellate Carteria taxa. Both data sets support the conclusion that Chlamydomonas is not monophyletic. The chloroplast data were ambiguous regarding Carteria monophyly while the nuclear data did not support it.
The document summarizes research on sequencing part of the ribosomal RNA coding region and determining the secondary structure of the 25S rRNA of Candida albicans. Key findings include:
- A rDNA cistron from C. albicans strain WO-1 was cloned and sequencing revealed the ITS1, ITS2, 5.8S rDNA and 25S rDNA coding regions.
- The C. albicans ITS regions are shorter than those of most other eukaryotes.
- The 5.8S and 25S rDNA sequences were used to model the secondary structure, which was compared to other species.
- Variable regions in the 25S r
This document summarizes our current understanding of DNA replication in archaea. It discusses how archaeal replication is more similar to eukaryotic replication than bacterial replication, though a simpler version. A key point is that while putative origins of replication have been identified in archaea based on genomic analysis, an unambiguous chromosomal origin has not been found. The document also provides overviews of DNA replication processes in general and the initiation phase more specifically to help frame the discussion of archaeal replication.
Dealing with heterogeneous data to improve our knowledge of biodiversity dynamics and ecosystem function: perspectives from synthesis projects: presented by Liliana Ballesteros-Meija for ACTIAS (Global patterns of insect diversity, distribution and evolutionary distinctness - What can we learn from two of the best-documented families of moths?) at the sfécologie conference 2018.
more information on the group: http://www.cesab.org/index.php/fr/projets-en-cours/projets-2014/130-actias
This document summarizes Carl Woese's contributions to science, particularly his discovery of the third domain of life (Archaea) through analysis of rRNA sequences. It describes how his work established the use of comparative analysis to determine rRNA secondary structure and identify structural motifs. It highlights that he envisioned comparative analysis providing details about RNA structure and energetics. The summary discusses Woese's seminal concepts regarding the need for a universal phylogenetic framework and how analysis of rRNA satisfied criteria to reconstruct evolutionary relationships across all life.
Gutell 123.app environ micro_2013_79_1803Robin Gutell
This document summarizes a study examining the host specificity of Lactobacillus bacteria associated with different hymenopteran (bee and ant) hosts. The researchers compiled nearly full-length 16S rRNA gene sequences of Lactobacillus from public databases and used these to construct phylogenetic trees. They also included shorter 16S sequences from surveys of bacteria associated with sweat bees, fungus-growing ants, and fire ants. The results showed that lactobacilli associated with honey bees and bumble bees are highly host specific, while sweat bees and ants associate with lactobacilli more closely related to those found in diverse environments or vertebrate hosts. The high host specificity seen in corbiculate bees (honey bees
Gutell R.R. (2013).
Comparative Analysis of the Higher-Order Structure of RNA.
in: Biophysics of RNA Folding. Volume editor: Rick Russell. Series title: Biophysics for the Life Sciences. Series editors: Norma Allewell, Ivan Rayment, Bertrand Garcia-Moreno, Jonathan Dinman, and Michael McCarthy. pp. 11-22. Publisher: Springer, New York, NY.
Gardner D.P., Xu W., Miranker D.P., Ozer S., Cannone J.J., and Gutell R.R. (2012).
An Accurate Scalable Template-based Alignment Algorithm.
Proceedings of 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), Philadelphia, PA. October 4-7, 2012. IEEE Computer Society, Washington, DC, USA. pp. 237-243.
Lee J.C. and Gutell R.R. (2012).
A Comparison of the Crystal Structures of the Eukaryotic and Bacterial SSU Ribosomal RNAs Reveals Common Structural Features in the Hypervariable Regions.
PLoS ONE, 7(5):e38203.
Gardner D.P., Ren P., Ozer S., and Gutell R.R. (2011).
Statistical Potentials for Hairpin and Internal Loops Improve the Accuracy of the Predicted RNA Structure.
Journal of Molecular Biology, 413(2):473-483.2011. pp 15-22.
Ozer S., Doshi K.J., Xu W., and Gutell R.R. (2011).
rCAD: A Novel Database Schema for the Comparative Analysis of RNA.
7th IEEE International Conference on e-Science, Stockholm, Sweden. December 5-8, 2011. pp 15-22.
Jiang Y., Xu W., Thompson L.P., Gutell R., and Miranker D. (2011).
R-PASS: A Fast Structure-based RNA Sequence Alignment Algorithm.
Proceedings of 2011 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2011), Atlanta, GA. November 12-15, 2011. IEEE Computer Society, Washington, DC, USA. pp. 618-622.
Xu W., Wongsa A., Lee J., Shang L., Cannone J.J., and Gutell R.R. (2011).
RNA2DMap: A Visual Exploration Tool of the Information in RNA's Higher-Order Structure.
Proceedings of 2011 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2011), Atlanta, GA. November 12-15, 2011. IEEE Computer Society, Washington, DC, USA. pp. 613-617.
Muralidhara C., Gross A.M., Gutell R.R., and Alter O. (2011).
Tensor Decomposition Reveals Concurrent Evolutionary Convergences and Divergences and Correlations with Structural Motifs in Ribosomal RNA.
PLoS ONE, 6(4):e18768.
Xia Z., Gardner D.P., Gutell R.R., and Ren P. (2010).
Coarse-Grained Model for Simulation of RNA Three-Dimensional Structures.
The Journal of Physical Chemistry B, 114(42):13497-13506.
The document describes research on fragmentation of the large subunit ribosomal RNA (LSU rRNA) gene in oyster mitochondrial genomes. Key findings include:
1) The LSU rRNA gene is split into two fragments separated by thousands of nucleotides in three species of oysters.
2) RT-PCR and EST analysis showed the two fragments are transcribed separately in Crassostrea virginica and are not spliced together.
3) Secondary structure models of the fragmented LSU rRNA genes were predicted for C. virginica, C. gigas, and C. hongkongensis based on comparative sequence analysis. This fragmentation represents a novel phenomenon in bilateral metazoan mitochondrial genomes.
Mueller U.G., Ishak H., Lee J.C., Sen R., and Gutell R.R. (2010).
Placement of attine ant-associated Pseudonocardia in a global phylogeny (Pseudonocardiaceae, Actinomycetales): a test of two symbiont-association models.
Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 98(2):195-212.
Theriot E.C., Cannone J.J., Gutell R.R., and Alverson A.J. (2009).
The limits of nuclear encoded SSU rDNA for resolving the diatom phylogeny.
European Journal of Phycology, 44(3):277-290.
Wu J.C., Gardner D.P., Ozer S., Gutell R.R. and Ren P. (2009).
Correlation of RNA Secondary Structure Statistics with Thermodynamic Stability and Applications to Folding.
Journal of Molecular Biology, 391(4):769-783.
Xu W., Ozer S., and Gutell R.R. (2009).
Covariant Evolutionary Event Analysis for Base Interaction Prediction Using a Relational Database Management System for RNA.
21st International Conference on Scientific and Statistical Database Management. June 2-4, 2009. Springer-Verlag. pp. 200-216.
Chen Y.P., Evans J.D., Murphy C., Gutell R., Zuker M., Gundersen-Rindal D., and Pettis J.S. (2009).
Morphological, Molecular, and Phylogenetic Characterization of Nosema cerenae, a Microsporidian Parasite Isolated from the European Honey Bee, Apis mellifera.
The Journal of Eukaryotic Microbiology, 56(2):142-147.
Maddison D.R., Moore W., Baker M.D., Ellis T.M., Ober K.A., Cannone J.J., and Gutell R.R. (2009).
Monophyly of terrestrial adephagan beetles as indicated by three nuclear genes (Coleoptera: Carabidae and Trachypachidae).
Zoologica Scripta, 38(1):43-62.
The document discusses the origin and evolution of the ribosome. It finds:
1) There is no single self-folding RNA segment that defines the small subunit's decoding site, while the large subunit's peptidyl transfer center is defined by one self-folding RNA segment.
2) The proteins contacting the small subunit's decoding site use universally alignable sequence blocks, while the large subunit's contact proteins use bacterial- or archaeal-specific blocks.
3) These differences support an earlier origin for the large subunit's peptidyl transfer center, with the small subunit's decoding site evolving later as an addition to the ribosome. The implications are that a single self-folding
GraphSummit Singapore | The Art of the Possible with Graph - Q2 2024Neo4j
Neha Bajwa, Vice President of Product Marketing, Neo4j
Join us as we explore breakthrough innovations enabled by interconnected data and AI. Discover firsthand how organizations use relationships in data to uncover contextual insights and solve our most pressing challenges – from optimizing supply chains, detecting fraud, and improving customer experiences to accelerating drug discoveries.
Unlocking Productivity: Leveraging the Potential of Copilot in Microsoft 365, a presentation by Christoforos Vlachos, Senior Solutions Manager – Modern Workplace, Uni Systems
Programming Foundation Models with DSPy - Meetup SlidesZilliz
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
Building Production Ready Search Pipelines with Spark and MilvusZilliz
Spark is the widely used ETL tool for processing, indexing and ingesting data to serving stack for search. Milvus is the production-ready open-source vector database. In this talk we will show how to use Spark to process unstructured data to extract vector representations, and push the vectors to Milvus vector database for search serving.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
At WSTS 2024, Alon Stern explored the topic of parametric holdover and explained how recent research findings can be implemented in real-world PNT networks to achieve 100 nanoseconds of accuracy for up to 100 days.
Communications Mining Series - Zero to Hero - Session 1DianaGray10
This session provides introduction to UiPath Communication Mining, importance and platform overview. You will acquire a good understand of the phases in Communication Mining as we go over the platform with you. Topics covered:
• Communication Mining Overview
• Why is it important?
• How can it help today’s business and the benefits
• Phases in Communication Mining
• Demo on Platform overview
• Q/A
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
Dr. Sean Tan, Head of Data Science, Changi Airport Group
Discover how Changi Airport Group (CAG) leverages graph technologies and generative AI to revolutionize their search capabilities. This session delves into the unique search needs of CAG’s diverse passengers and customers, showcasing how graph data structures enhance the accuracy and relevance of AI-generated search results, mitigating the risk of “hallucinations” and improving the overall customer journey.
Removing Uninteresting Bytes in Software FuzzingAftab Hussain
Imagine a world where software fuzzing, the process of mutating bytes in test seeds to uncover hidden and erroneous program behaviors, becomes faster and more effective. A lot depends on the initial seeds, which can significantly dictate the trajectory of a fuzzing campaign, particularly in terms of how long it takes to uncover interesting behaviour in your code. We introduce DIAR, a technique designed to speedup fuzzing campaigns by pinpointing and eliminating those uninteresting bytes in the seeds. Picture this: instead of wasting valuable resources on meaningless mutations in large, bloated seeds, DIAR removes the unnecessary bytes, streamlining the entire process.
In this work, we equipped AFL, a popular fuzzer, with DIAR and examined two critical Linux libraries -- Libxml's xmllint, a tool for parsing xml documents, and Binutil's readelf, an essential debugging and security analysis command-line tool used to display detailed information about ELF (Executable and Linkable Format). Our preliminary results show that AFL+DIAR does not only discover new paths more quickly but also achieves higher coverage overall. This work thus showcases how starting with lean and optimized seeds can lead to faster, more comprehensive fuzzing campaigns -- and DIAR helps you find such seeds.
- These are slides of the talk given at IEEE International Conference on Software Testing Verification and Validation Workshop, ICSTW 2022.
In the rapidly evolving landscape of technologies, XML continues to play a vital role in structuring, storing, and transporting data across diverse systems. The recent advancements in artificial intelligence (AI) present new methodologies for enhancing XML development workflows, introducing efficiency, automation, and intelligent capabilities. This presentation will outline the scope and perspective of utilizing AI in XML development. The potential benefits and the possible pitfalls will be highlighted, providing a balanced view of the subject.
We will explore the capabilities of AI in understanding XML markup languages and autonomously creating structured XML content. Additionally, we will examine the capacity of AI to enrich plain text with appropriate XML markup. Practical examples and methodological guidelines will be provided to elucidate how AI can be effectively prompted to interpret and generate accurate XML markup.
Further emphasis will be placed on the role of AI in developing XSLT, or schemas such as XSD and Schematron. We will address the techniques and strategies adopted to create prompts for generating code, explaining code, or refactoring the code, and the results achieved.
The discussion will extend to how AI can be used to transform XML content. In particular, the focus will be on the use of AI XPath extension functions in XSLT, Schematron, Schematron Quick Fixes, or for XML content refactoring.
The presentation aims to deliver a comprehensive overview of AI usage in XML development, providing attendees with the necessary knowledge to make informed decisions. Whether you’re at the early stages of adopting AI or considering integrating it in advanced XML development, this presentation will cover all levels of expertise.
By highlighting the potential advantages and challenges of integrating AI with XML development tools and languages, the presentation seeks to inspire thoughtful conversation around the future of XML development. We’ll not only delve into the technical aspects of AI-powered XML development but also discuss practical implications and possible future directions.
UiPath Test Automation using UiPath Test Suite series, part 5DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 5. In this session, we will cover CI/CD with devops.
Topics covered:
CI/CD with in UiPath
End-to-end overview of CI/CD pipeline with Azure devops
Speaker:
Lyndsey Byblow, Test Suite Sales Engineer @ UiPath, Inc.
“An Outlook of the Ongoing and Future Relationship between Blockchain Technologies and Process-aware Information Systems.” Invited talk at the joint workshop on Blockchain for Information Systems (BC4IS) and Blockchain for Trusted Data Sharing (B4TDS), co-located with with the 36th International Conference on Advanced Information Systems Engineering (CAiSE), 3 June 2024, Limassol, Cyprus.
Let's Integrate MuleSoft RPA, COMPOSER, APM with AWS IDP along with Slackshyamraj55
Discover the seamless integration of RPA (Robotic Process Automation), COMPOSER, and APM with AWS IDP enhanced with Slack notifications. Explore how these technologies converge to streamline workflows, optimize performance, and ensure secure access, all while leveraging the power of AWS IDP and real-time communication via Slack notifications.
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdfMalak Abu Hammad
Discover how MongoDB Atlas and vector search technology can revolutionize your application's search capabilities. This comprehensive presentation covers:
* What is Vector Search?
* Importance and benefits of vector search
* Practical use cases across various industries
* Step-by-step implementation guide
* Live demos with code snippets
* Enhancing LLM capabilities with vector search
* Best practices and optimization strategies
Perfect for developers, AI enthusiasts, and tech leaders. Learn how to leverage MongoDB Atlas to deliver highly relevant, context-aware search results, transforming your data retrieval process. Stay ahead in tech innovation and maximize the potential of your applications.
#MongoDB #VectorSearch #AI #SemanticSearch #TechInnovation #DataScience #LLM #MachineLearning #SearchTechnology
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!SOFTTECHHUB
As the digital landscape continually evolves, operating systems play a critical role in shaping user experiences and productivity. The launch of Nitrux Linux 3.5.0 marks a significant milestone, offering a robust alternative to traditional systems such as Windows 11. This article delves into the essence of Nitrux Linux 3.5.0, exploring its unique features, advantages, and how it stands as a compelling choice for both casual users and tech enthusiasts.