Poliomyelitis, or polio, is a highly infectious disease that primarily affects children under 5 years old and can cause paralysis or death. While global polio cases have decreased by 99% since 1988 due to vaccination efforts, eradication has not been fully achieved due to issues like limited health infrastructure, vaccine effectiveness in some climates, outbreaks of vaccine-derived poliovirus, and opposition to vaccination in some areas. Ghana has implemented initiatives like mass vaccination campaigns and public education to eliminate polio domestically.
Past and future of eradication and elimination of different diseases. How to plan for elimination and eradication. What are the diseases can be eliminated? OPV to IPV shift!
Past and future of eradication and elimination of different diseases. How to plan for elimination and eradication. What are the diseases can be eliminated? OPV to IPV shift!
Sustained research successes during the first two decades of the AIDS epidemic, an unprecedented expansion of HIV prevention and treatment programs during the last decade, and recent global attention and leadership have set the stage for the virtual elimination of new HIV infections in infants in the next decade.
Poliomyelitis And Barriers to Its Eradication in Pakistan by Ateeqa Ijaz.pptxAteeqa4
A brief history and epidemiology of poliomyelitis. Also, a thorough description of the Global polio eradication initiative with the barriers to its eradication in Pakistan.
2018 polio eradication for bay of plenty grand roundMichelle Tanner
Polio eradication and my personal experiences of being invited to Pakistan as a Rotarian and nurse expert on immunisations, to present at a Rotary polio eradication conference and participate in polio and polio education activities.
Presentation from the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), published by the European Centre for Disease Prevention and Control (ECDC)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Sustained research successes during the first two decades of the AIDS epidemic, an unprecedented expansion of HIV prevention and treatment programs during the last decade, and recent global attention and leadership have set the stage for the virtual elimination of new HIV infections in infants in the next decade.
Poliomyelitis And Barriers to Its Eradication in Pakistan by Ateeqa Ijaz.pptxAteeqa4
A brief history and epidemiology of poliomyelitis. Also, a thorough description of the Global polio eradication initiative with the barriers to its eradication in Pakistan.
2018 polio eradication for bay of plenty grand roundMichelle Tanner
Polio eradication and my personal experiences of being invited to Pakistan as a Rotarian and nurse expert on immunisations, to present at a Rotary polio eradication conference and participate in polio and polio education activities.
Presentation from the European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE), published by the European Centre for Disease Prevention and Control (ECDC)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. TOPIC: POLIOMYELITIS IN CHILDREN
• The focal point of this presentation is on poliomyelitis
• Its impact on the society, management and possible solutions.
3. ABSTRACT
• This presentation focuses on polio and how the prevalence about 1%.
• Polio is a highly infectious disease caused by the poliovirus.
• It primarily affects children under the age of 5 and can lead to
permanent paralysis and even death, however, anyone of any age
who is unvaccinated can contract the disease.
• Outbreaks of polio are more likely to occur in communities where
there are unimmunized children and coupled with poor sanitary and
hygiene environments. WHO(2022).
4. INTRODUCTION
• In 1988, the World Health Assembly adopted a resolution for the
worldwide eradication of polio, marking the launch of the Global Polio
Eradication Initiative (GPEI)
• It was spearheaded by national governments, WHO, Rotary
International, the US Centers for Disease Control and Prevention
(CDC), UNICEF, and Bill & Melinda Gates. WHO(2022).
• Since then, the incidence of polio worldwide has been reduced by
99% from an estimated 350,000 cases in more than 125 endemic
countries then, to 6 reported cases in 2021.
5. INTRODUCTION
• According to the World Health Organization, there has been a
significant reduction from the 350,000 cases reported in 1988 to
140 reported cases of wild poliovirus worldwide in 2020.
• On average between 1950 and 1955, WHO recorded annual
prevalence of almost 85,000 of which 87% originated from Europe,
Asia , North America and Japan.
• In 1994, WHO region of America was certified as polio-free, followed
by the Pacific region in 2000; European and South-East Asiain the year
2002 and 2014 respectively.
6. INTRODUCTION
• In 2020, Africa became the fifth region to be certified wild poliovirus-
free
• The Polio Eradication Strategy 2022–2026 lays out the roadmap to
securing a lasting and sustained world, free of all polioviruses.
7. WHY ERADICATION OF POLIO HAS NOT BEEN
ACHIEVED
• In spite of the 1% prevalence rate globally, the eradication of
Poliomyelitis has not been achieved due to;
• The lack of basic health infrastructure, which limits vaccine
distribution and delivery.
• The climate conditions which affects the potency of vaccines.
• vaccine-derived poliovirus outbreaks and funding issues.
• Inadequate mobilisation of community groups.
• Opposition to vaccination in some countries and some regions in
Ghana
8. GHANA’S INITIATIVE TO ERADICATE POLIO
• Various measures were put in place to eradicate polio in childeren.
• Ensuring high immunization coverage.
• Robust surveillance for the signs and symptoms of polio.
• Implementation of polio vaccination campaigns targeting children
under five years across all 16 regions of Ghana.
• Rapid response to any detection of the virus.
• Organisation on educational forums and campaigns for public
education and sensitization.
9. • Globally, the Polio Eradication Strategy 2022–2026 offers a
comprehensive set of actions that will position the GPEI to deliver on
a promise that brought the world together in a collective
commitment to eradicate polio.
• The Government of Ghana, with the support of the World Health
Organization (WHO) and other partners of the Global Polio
Eradication Initiative (GPEI),has revived its drive to eradicate polio
(WHO,2022).
10.
11. METHODOLOGY
• In 1974, Nicholas, Ofosu-Amaah and their colleagues conducted a
research on lame children, initially identified by school teachers as
being unable to walk normally.
12. FINDINGS
• They found out that, the annual incidence of polio in children in
Ghana, at 232 per million population, was twice as high as it has been
in the United State before vaccination.
• The polio was the cause of the disability in over 60% in the lame
children examined.
• In August 2020, Africa was declared free of poliomyelitis (polio),
bringing to fruition a goal that took more than 30 years to
achieve.(Mohammed & Nkengasong,2021).
13. FINDINGS
• By 2001, 575 million children (almost one-tenth the world's
population) had received some two billion doses of oral polio vaccine.
• In 2007, there were 1,315 cases of poliomyelitis reported worldwide.
14. REFERENCES
1. Estivariz, Concepcion F.; Link-Gelles, Ruth; Shimabukuro, Tom (2021). "Chapter 18: Poliomyelitis". In Hall, Elisha; Wodi, A. Patricia; Hamborsky,
Jennifer; Morelli, Valerie; Schillie, Sarah (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book) (14th ed.). Centers
for Disease Control and Prevention (CDC, US).
2. Poliomyelitis: Key facts". World Health Organisation. 22 July 2019.
3. CDC (29 March 2022). "What is Polio?". Centers for Disease Control and Prevention.
4. Nathanson N, Martin JR. The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidemicity, and disappearance. Am J
Epidemiol. 1979 Dec;110(6):672-92.
5. Global Polio Eradication Initiative, World Health Organization (April 2015). Polio environmental surveillance expansion plan: global expansion plan
under the endgame strategy 2013-2018 (PDF) (Report). World Health Organization (WHO).
6. Hiromasa Okayasu; Carolyn Sein; Diana Chang Blanc; Alejandro Ramirez Gonzalez; Darin Zehrung; Courtney Jarrahian; Grace Macklin; Roland W.
Sutter (2017). "Intradermal Administration of Fractional Doses of Inactivated Poliovirus Vaccine: A Dose-Sparing Option for Polio Immunization"
(PDF). The Journal of Infectious Diseases. 216 (S1): S161–7.
7. Edward P K Parker; Natalie A Molodecky; Margarita Pons-Salort; Kathleen M O'Reilly; Nicholas C Grassly (2015). "Impact of inactivated poliovirus
vaccine on mucosal immunity: implications for the polio eradication endgame". Expert Review of Vaccines. 14 (8): 1113–1123.
8. Patel JC, Diop OM, Gardner T, Chavan S, Jorba J, Wassilak SG, Ahmed J, Snider CJ (April 2019). "Surveillance to Track Progress Toward Polio
Eradication - Worldwide, 2017-2018" (PDF). Morbidity and Mortality Weekly Report. 68 (13): 312–318.
9. Mohammed, A., Tomori, O. & Nkengasong, J.N.(2021). Lessons from the elimination of poliomyelitis in Africa. Nat Rev Immunol 21, 823–828.
10. Agyei-Mensah, Samuel; Aikins, Ama de-Graft (2010). "Epidemiological Transition and the Double Burden of Disease in Accra, Ghana". Journal of
Urban Health. 87 (5): 879–897.