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Preventive pharmacology

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Angelo Tremblay

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Preventive pharmacology

  1. 1. How do wepreventobesityin 2011?<br />Angelo Tremblay<br />Division of Kinesiology<br />
  2. 2. How do wepreventobesityin 2011?<br /><ul><li>By counteracting the impact of obesogenicenvironmentalfactors
  3. 3. By promotingadequatesleep
  4. 4. By increasing the physicalwork/cognitive effort ratio
  5. 5. By investing in nutrition competence and healthyfoodavailability
  6. 6. By promotinghealthyfood-relatedbehaviours
  7. 7. By investing in preventivepharmacology!!</li></li></ul><li>Is methylphenidate (Ritalin) the solution?<br />
  8. 8. Wholebrainmetabolismwhen the cognitive taskwasgivenwith:<br />Placebo increased 21%<br />Methylphenidateincreased 11% (50% less)<br />FromVolkow N.D. et al, PLoS ONE 2008<br />
  9. 9. Methylphenidatereducesenergyintake and dietary fat intakeduring a buffet-style meal in adults<br />Variable Mean change (%)<br />Energyintake -11*<br />Fat intake -17*<br />Values are means<br />* Significantdifference versus a placebo condition: p < 0.05<br />Adaptedfrom Goldfield GS. AJCN 86: 308-315, 2007<br />
  10. 10. Treatment:<br />Medications used include mixed salts amphetamine (Adderall XR), mythylphenidate sustained-release capsule (Concerta), and sustained release destroamphetamine sulfate (Dexedrine Spansules).<br />All participants, including control subjects, were offered individual assessment and diet instruction by the clinic’s registered dietitian.<br />All participants were counselled regarding the need to be physically more activie.<br />Duration of ADHD management: 466 days<br />
  11. 11. Body weight changes with ADHD management<br />ADHD-treated subjects Untreated controls<br /> (n = 65) (n = 13)<br /> body weight (kg) -15.05 +3.26*<br /> (%) -12.36 +2.78*<br />*Significant difference between groups, p < 0.001<br />Adapted from Levy LD et al, Int J Obes<br />33: 326-334, 2009<br />
  12. 12. How do wepreventobesityin 2011?<br /><ul><li>By counteracting the impact of obesogenicenvironmentalfactors
  13. 13. By promotingadequatesleep
  14. 14. By increasing the physicalwork/cognitive effort ratio
  15. 15. By investing in nutrition competence and healthyfoodavailability
  16. 16. By promotinghealthyfood-relatedbehaviours
  17. 17. By investing in preventivepharmacology !!!</li>

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