Interventional pain management by dr rajeev harsheRajeev Harshe
This is a brief presentation on how pain can be managed in a better way. Dr Rajeev Harshe is senior pain management consultant in western India. He is attached to Apollo Hospitals and has his private consulting room as well.Email: dr.harshe@gmail.com. If you are anaesthesiologist and if you wish to learn pain management,contact him.
Acute pain management requires a multimodal and multidisciplinary approach with a clear organization framework. Regional anesthesia techniques for surgical anesthesia are a highly effective component of acute pain management.
With the advancement of ultrasonographic technology with higher resolution and penetration imaging, there is increasing use of ultrasonography (US) in acute and chronic pain blocks.
Interventional pain management by dr rajeev harsheRajeev Harshe
This is a brief presentation on how pain can be managed in a better way. Dr Rajeev Harshe is senior pain management consultant in western India. He is attached to Apollo Hospitals and has his private consulting room as well.Email: dr.harshe@gmail.com. If you are anaesthesiologist and if you wish to learn pain management,contact him.
Acute pain management requires a multimodal and multidisciplinary approach with a clear organization framework. Regional anesthesia techniques for surgical anesthesia are a highly effective component of acute pain management.
With the advancement of ultrasonographic technology with higher resolution and penetration imaging, there is increasing use of ultrasonography (US) in acute and chronic pain blocks.
CPSP is a new emerging disease but can be a silent epidemic.
Optimal perioperative management may reduce the incidence of CPSP.
Minimal invasive surgical techniques
Agressive perioperative multimodal analgesia, inluding epidural or nerve blocks.
Appropriate management of acute pain is therefore not only a humane obligation, but also may prevent of chronic pain!
Effectiveness and safety of CPNB and continuous local wound infusion
Basal infusion with PCA option
Types of pumps – elastomeric vs. electronic
Outpatient and home infusion pumps
Pain Physicians should consider nerve blocks when systemic analgesics are failing. (Adjuvant therapy)
Careful selection of patients
Benefits should outweigh the risks
Thorough knowledge of the limitations and side effects
Need for randomized controlled clinical trials.
Option of interventional pain therapy in multimodal treatment of chronic cancer and non-cancer pain
Established role when pharmacotherapy or surgery not suitable
Indications well accepted
Evidence for efficacy moderate to strong
Abstract:
Procedures were performed for the total population in the period from March 2015 to November 2015 Cairo, Egypt. Pulsed Radiofrequency (PRF) using Ultrasound guidance (USG) has been used on medial branches supplying lumbar facet joints, investigating it’s effect in managing low back pain(LBP) caused by lumbar facet arthropathy . Conventional Radiofrequency (RF) using Fluoroscopy guidance (FG) on the medial branches is another option in treating facet arthropathy. This study is aimed to investigate the effects of PRF and RF on medial branches for facetogenic lumbar pain, demonstrating alternative ways to failed conservative methods and contradictory scientific evidence on minimally invasive procedures such as intra-articular steroid infiltration.
Chronic pain after surgery. More than just a nuisance?
Chronic pain can complicate a third of even relatively minor surgical procedures with far-reaching consequences for patient and family. Why does it happen? What can be done to mitigate the problem?
A seminar in three movements held jointly with the Glasgow Southern Medical Society:
'Magnitude' Dr William Macrae, Dundee
'Molecules' Dr Mick Serpell, Glasgow
'Meaning' Dr David Craig, Glasgow
In this lecture, Dr Bill Macrae discusses the magnitude of the problem.
We present a novel surgical technique, that involves the use of two unilateral placed portals to accomplish a full cervical endoscopic laminoforaminotomy on a 39 yo male suffering from a left C7 radiculopathy. See the presentation and video included.
CPSP is a new emerging disease but can be a silent epidemic.
Optimal perioperative management may reduce the incidence of CPSP.
Minimal invasive surgical techniques
Agressive perioperative multimodal analgesia, inluding epidural or nerve blocks.
Appropriate management of acute pain is therefore not only a humane obligation, but also may prevent of chronic pain!
Effectiveness and safety of CPNB and continuous local wound infusion
Basal infusion with PCA option
Types of pumps – elastomeric vs. electronic
Outpatient and home infusion pumps
Pain Physicians should consider nerve blocks when systemic analgesics are failing. (Adjuvant therapy)
Careful selection of patients
Benefits should outweigh the risks
Thorough knowledge of the limitations and side effects
Need for randomized controlled clinical trials.
Option of interventional pain therapy in multimodal treatment of chronic cancer and non-cancer pain
Established role when pharmacotherapy or surgery not suitable
Indications well accepted
Evidence for efficacy moderate to strong
Abstract:
Procedures were performed for the total population in the period from March 2015 to November 2015 Cairo, Egypt. Pulsed Radiofrequency (PRF) using Ultrasound guidance (USG) has been used on medial branches supplying lumbar facet joints, investigating it’s effect in managing low back pain(LBP) caused by lumbar facet arthropathy . Conventional Radiofrequency (RF) using Fluoroscopy guidance (FG) on the medial branches is another option in treating facet arthropathy. This study is aimed to investigate the effects of PRF and RF on medial branches for facetogenic lumbar pain, demonstrating alternative ways to failed conservative methods and contradictory scientific evidence on minimally invasive procedures such as intra-articular steroid infiltration.
Chronic pain after surgery. More than just a nuisance?
Chronic pain can complicate a third of even relatively minor surgical procedures with far-reaching consequences for patient and family. Why does it happen? What can be done to mitigate the problem?
A seminar in three movements held jointly with the Glasgow Southern Medical Society:
'Magnitude' Dr William Macrae, Dundee
'Molecules' Dr Mick Serpell, Glasgow
'Meaning' Dr David Craig, Glasgow
In this lecture, Dr Bill Macrae discusses the magnitude of the problem.
We present a novel surgical technique, that involves the use of two unilateral placed portals to accomplish a full cervical endoscopic laminoforaminotomy on a 39 yo male suffering from a left C7 radiculopathy. See the presentation and video included.
A NALYSIS OF P AIN H EMODYNAMIC R ESPONSE U SING N EAR -I NFRARED S PECTROSCOPYijma
Despite recent advances in brain research, understa
nding the various signals for pain and pain intensi
ties
in the brain cortex is still a complex task due to
temporal and spatial variations of brain haemodynam
ics.
In this paper we have investigated pain based on ce
rebral hemodynamics via near-infrared spectroscopy
(NIRS). This study presents a pain stimulation expe
riment that uses three acupuncture manipulation
techniques to safely induce pain in healthy subject
s. Acupuncture pain response was presented and
Haemodynamic pain signal analysis showed the presence of dominant channels and their relationship
among surrounding channels, which contribute the fu
rther pain research area.
INTRODUCTION, PRINCIPLES, APPLICATIONS and FUTURE , uses in abdominal, pelvic, obstretics fields and analysis of flow pattern of the blood in the vessels
Neck pain is an aching, burning, stabbing, shooting, or cramping pain. PCI is well known Neck Pain Treatment Clinic in Mumbai. Visit http://goo.gl/pqRBvJ & Get Relief from Neck Pain
Clinical Experience in Maxillary and Mandibular division block for Trigeminal...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
comparative evaluation of effects of different doses of intrathecal clonidine...Dr Ravi Shankar Sharma
this was the winning paper as best free paper in MPISACON14 GWAlOR,which demonstrates comparative evaluation of effects of different doses of intrathecal clonidine with bupivacaine on post operative pain releif
Abstract
A total of 50 procedures were performed, 25 patients were treated using SpineView decompressor and 25 patients by Nucleoplasty using the Arthrocare Coblation technology. The total population had leg pain (sciatica), 30 of which had low back pain (discogenic pain) . Mean age of patients was 30 – 60 years. The mean follow-up period was 1 year. Follow up was done weekly for the first 2 months then monthly for the first year post-procedure according to Visual Analogue Scale , Urs Muller et.al.(2008) as well as featured neurological examination.
Analgesic consumption was stopped or reduced in 9 of the 15 patients with sciatica and low back pain treated with SpineView decompressor (60%) at 2 months (66%) 4months after the procedure, and in 9 of the 15 patients with sciatica and low back pain treated by Nucleoplasty using the Arthrocare Coblation technology (60%) at 2 months (66%) 4months after the procedure.
The patients who had sciatica only has shown reduction in analgesic consumption in 9 of the 10 patients who were treated with SpineView decompressor (90%) at 2 months, and in 2 of the 10 patients who were treated by Nucleoplasty using the Arthrocare Coblation technology (20%) at 2 months.
Our results encourage us to use SpineView decompressor in carefully selected patients with sciatica and small contained disc protrusion . Also we find that applying Nucleoplasty using the Arthrocare Coblation technology in those patients with low back pain and small contained disc protrusion can give satisfactory results. These results need further efforts and researches in order to be general recommendations.
ESP block - future direction and remaining questionsAmit Pawa
This Talk was delivered by Dr Pawa on 5th June 2021 as part of the ISURA 2021 hybrid conference held in Toronto.
The Future Direction of this block and remaining questions to be answered are covered here
Tips and tricks to site and maintain nerve cathetersAmit Pawa
This lecture was given on Friday 13th September 2019 at the annual congress of the European Society of Regional Anaesthesia in Bilbao and Spain. The talk was also contributed to by the Twitter Community. Strategies and techniques to site, secure and maintain perineural nerve catheters is discussed
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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1. 1
Ultrasound-guided pain blocks
Greater Occipital Nerve, Third Occipital
Nerve and Cervical Plexus
9th A l I t ti l S i f Ult d f9th Annual International Symposium of Ultrasound for
Regional Anaesthesia and Pain Medicine
ISURA, Toronto, Canada, June 22-25, 2012
Urs Eichenberger MD, PhD
Department of Anaesthesiology, Intensive Care and Pain
Medicine, St. Anna Clinic, Lucerne and University of Bern,
Switzerland
Greater occipital nerve (GON) block
1 = obliquus capitis
inferior muscle
1
1
Standard “blind”
approach of GON
block
New approach: more
centrally where it is
1 Obliquus capitis inferior muscle
2 Greater occipital nerve (GON)
usually not divided and
can be seen better by
ultrasound
Greher M et al., Br J Anaesth 2010
Our new approach:
more centrally where
1 Obliquus capitis inferior muscle
2 Greater occipital nerve (GON)
it is usually not
divided and can be
seen better by
ultrasound
Greher M et al., Br J Anaesth 2010
1
Nerve supply (TON) and
background C2/3 joint pain
> Pain after whiplash injury is
common and in up to 50% of cases
cervical facet joints are the reason
Lord et al, Spine 1996
> The only reliable diagnostic is the
diagnostic block of the nerves
innervating the joint (medial
branches)
Barnsley et al., Pain 1993
Siegenthaler et al., Anesth Analg 2010
> After two times positive diagnostic
block - there is an evidence based
and effective therapy: RF ablation
of the nerves
Lord et al., NEJM 1996
TON innervates the joint
C 2/3 and a small skin area
Diagnostic nerve block (TON) for
cervical zygapophysial joint pain C2/3
> Easy and fast by fluoroscopy
> 2 positive diagnostic blocks
— VAS reduction > 90%
— Duration lidocaine < bupivacainep
> Radiofrequency ablation gives
same result in about 70% of cases
up to 1 year
> Question: nerve (TON) visible by
ultrasound?
2. 2
Why ultrasound?
Are there any advantages?
> Visualisation of neighboured vulnerable
structures
=> Target: needle guidance without touching
these structures
> Spread of local anaesthetic visible
=> Correction of needle tip position if needed
> Reduction in radiation exposure
3rd occipital nerve (TON) block
Volunteer study, ultrasound guidance
> Our first study in Bern in the
field of ultrasound guided
pain therapy 2003.
> 10 volunteers on both sides.
Eichenberger et al., Anesthesiology 2006
> We could visualize the
nerve in all volunteers,
position the needle
(fluoroscopic control) and
block the nerve accurately
(skin test after saline and
LA injection)
Third occipital nerve (TON)
30
35
40
45
50
nts
Good
Visibility of TON in patients
Data of 50 pain patients admitted for cervical blocks
0
5
10
15
20
25
30
C2-3 C3 C4 C5 C6 C7
No.Patie
Good
Difficult
Impossible
Siegenthaler et al, RAPM 2011
D1 D2
C2/3
C3/4
TON
mbC3
*
*
bony target bony target
Relation TON to bony
target points
Siegenthaler et al, RAPM 2011
My practical approach for TON block
using ultrasound
> If nerve can be seen, 0.5 - 1 ml of LA to the nerve under
sight
> Longitudinal transducer position (to see the nerve)
> I prefer the short axis approach (superficial target)
> Needle from anterior to posterior> Needle from anterior to posterior
> If positive first block: second block using 0.5 ml of LA and
fluoroscopy as control
> Radiofrequency-ablation of the nerve: always fluoroscopy
as control, needle position under US (legal reasons)
3. 3
Potential of ultrasound for novel
radiofrequency neurotomy technique?
> Scan nerve and its
course in relation to
articulation
> RF probe under> RF probe under
ultrasound guidance
close to nerve
> Only one ore two lesions
> Same results?
> 15 patients
> Time needed for RF-
ablation: 35 min
> Pain reduction ≥ 80%:
— 13 patients after 6
months
6 ti t ft 12
Novel radiofrequency neurotomy technique
— 6 patients after12
months
> Median duration until
pain was 50% of initial
pain: 44 weeks
Results comparable with
traditional method but
procedure much faster Siegenthaler et al. Pain Med 2011
Anatomy plexus cervicalis: skin innervation Ultrasound images of cervical nerve roots
Ultrasound images of cervical nerve roots