The gluteal region contains important muscles that control movement of the hip and thigh. The piriformis muscle divides the greater sciatic foramen, with structures passing above or below it. Deep muscles like piriformis, obturator internus and quadratus femoris laterally rotate the femur. Superficial muscles like gluteus maximus, medius and minimus abduct and extend the hip. Nerves like the superior and inferior gluteal innervate these muscles. The sciatic nerve passes through the gluteal region en route to the lower limb. Landmarks are used to safely administer intramuscular injections into the gluteus maximus muscle.