Global Immunoassay Systems Industry

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Global Immunoassay Systems Industry
Published on August 2010

Report Summary

This report analyzes the worldwide markets for Immunoassay Systems in US$ Million by the following product segments - Enzyme
Immunoassay Systems, Fluorescence Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay
Systems, and Nephelometric Immunoassay Systems. The report provides separate comprehensive analytics for the US, Canada,
Japan Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for each region for the
period 2007 through 2015. A six-year historic analysis is also provided for these markets. The report profiles 69 companies including
many key and niche players such as Abbott Laboratories, Beckman Coulter Inc., bioMérieux, Bio-Rad Laboratories Inc., Ortho-Clinical
Diagnostics Inc., Roche Diagnostics, and Siemens Healthcare Diagnostics. Market data and analytics are derived from primary and
secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

Table of Content

IMMUNOASSAY SYSTEMSMCP-3522
A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-3
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Enzyme Immunoassay I-4
Fluorescence Immunoassay I-4
Chemiluminescence Immunoassay I-4
Radioimmunoassay I-5
Nephelometric Immunoassay I-5

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
In-Vitro Diagnostics - A Rudimentary Overview II-1
Technologies Used in IVD II-1

Global Immunoassay Systems Industry (From Slideshare) Page 1/20


Market Structure II-2
Factors Influencing IVD Industry: On a Scale of 1-5 II-3
Key Statistical Findings: II-3
Table 1: World In-Vitro Diagnostic Products Market by
End-Use Segment (2009) - Percentage Breakdown by Value
Sales for Hospital Labs, Commercial Labs, Self-Testing and
POC (includes corresponding Graph/Chart) II-3

Table 2: Global IVD Market (2008): Percentage Share
Breakdown of Value Sales by Country/Region (includes
corresponding Graph/Chart) II-3

Breakdown of Revenue by Product Segment (includes
Competition in the IVD Market II-4
Breakdown of Value Sales by Leading Players (includes
Immunoassays - A Key Component in the IVD Market II-5
Waxing Importance of Immunoassays in the Overall Diagnostic
Test Market II-5
Expanding Immunoassay Applications Boost Demand for
Immunoassay Systems II-6
Table 5: Global Laboratory Based Immunoassay Market (2009):
Percentage Share Breakdown of Value Sales by Analyte Type
(includes corresponding Graph/Chart) II-7

Table 6: Recent Past Perspective of the World Immunoassay
Market by End-Use Industry (2006): Percentage Breakdown by
Value Sales for Clinical, Food and Environment Industries
Increasing Use of Immunoassays in Food Sciences and Quality
Control II-7
Immunoassay Techniques for Testing Environmental Samples
Makes a Mark II-8
Application of Immunoassays for Trace Methodology II-8
Technology Innovation - The Name of the Game II-8
Table 7: Worldwide Immunoassay Systems Market (2007) -
Percentage Share Breakdown of Value Sales by Leading Players

2. INDUSTRY TRENDS & ISSUES II-10
Shift Towards Point-of-Care Test Systems II-10
Hospital and Laboratory Consolidations Drive the Market for
Immunoassay Products II-10
Advancement in Genetic Research Drives the Growth II-10
Introduction of Portable Immunoassay Systems Energizes the



Market II-11
Increasing Demand for Random Access Immunoanalyzers..... II-11
Task-Targeted Automated Chemiluminescent Assays to Penetrate II-11
Instrument Rental - Name of the New Game... II-11
Changing Scene for Immunodiagnostic Testing... II-11
Laboratory Automation on Rise II-12
Market for Adjunctive Therapies to Grow Fast II-12

3. CONCEPTUAL OVERVIEW II-13
Immunoassays - Definition and Description.... II-13
Turning the Hour Glass Back II-13
Immunoassay Analyzers II-13
Immunoassay Reagents II-14
Radioimmunoassay II-14
Non-Isotopic Immunoassays II-14
Customized Immunoassays II-15
Demerits of Immunoassays II-15
Labels - Necessary for Detection II-15
Select End-Use Applications of Immunoassays II-16
Infectious Disease II-16
Endocrine Testing Procedures II-16
Blood Processing Market II-16
Cancer Testing Markets II-17
Drugs of Abuse Testing Market II-17
Therapeutic Drug Monitoring II-18
Immune Disease II-18
Blood Grouping and Typing II-18
Components of Immunoassays II-18
Signal Response II-19
Labeled Tracer II-19
Binder II-19
Buffer Matrix II-19
Incubation Conditions II-19
Separation Process II-19
Standard Specimens II-20
Control Specimens II-20
Unknown Specimens II-20
Chemiluminescent Substrates - Growing Appeal II-20
Radioimmunoassay Analyzers, Gamma Counters II-20
Fundamentals of Operation II-21
Problems Involved II-22
Enzyme Immunoassay Analyzers, Fluorescence Immunoassay
Analyzers and Chemiluminescence's Immunoassay Analyzers II-23
Enzyme Immunoassays II-24
Automation Enabled II-24
Customization of Assays II-24
ELISA - A Flexible Enzyme Immunoassay Test..... II-25
Constituents of ELISA II-25



Working II-25
Binding the Antigen and Antibody II-25
Conjugate Binding II-26
Evidence of Binding II-26
Fluorescence Immunoassay - Operating Principle II-26
Light Sources II-26
Sample Cell II-26
Filters II-27
Detector II-27
Time-Resolved Fluoroimmunoassay II-27
Chemiluminescence Immunoassay II-27
Types of Immunoassay Techniques II-28
Fluorescence Polarization Immunoassay II-28
Radiative Energy Attenuation (REA) II-28
Substrate-Labeled Fluorescence II-29
Enzyme Immunoassay with Fluorescence Detection II-29
Solid-Phase Microsphere Immunoassay II-29
Microparticle Enzyme Immunoassay (MEIA) II-30
Enzyme-Linked Fluorescence Immunoassay II-30
ELISA With Photometric Detection II-30
Dry-Phase Techniques II-31
Sandwich Technique II-31
Competitive Binding II-31
Reversible Complex Formation II-31
The Phase of Development II-31
Problems and Limitations.... II-32
Purchase Considerations..... II-33
Cost Considerations.... II-33
Nephelometric Immunoassay II-33
Nephelometry II-34
Types of Scatter...... II-34
Rayleigh Scatter II-34
Mie Scatter II-34
Rayleigh-Debye Scatter II-34
Key Components of Nephelometric Immunoassay Analyzers.... II-34
Light Sources II-35
Detectors II-35
Automated Nephelometers.... II-35
Modes of Operation.... II-36
Nephelometric Immunoassay Procedures.... II-36
Associated Problems...... II-37
Purchase Considerations.... II-37
Test Menu II-38
Analytical Range II-38
Linearity II-38
Specificity II-38
Precision II-38
Stability II-38



Carryover II-38
Downtime II-39
Upgrading / Interfacing II-39
Reagents II-39
Additional Features..... II-39
Competing Technologies II-39
Mature Technologies..... II-39
Cell Counting II-39
Clinical Chemistry II-40
Microbiology II-40
Emerging Technologies...... II-40
DNA Probes II-40
Miniaturization and Microchip Fabrication II-40
Blood Glucose Testing II-41
Immunohistochemistry (IHC) II-41
Non-Invasive Technology II-41
Image Analysis and Pattern Recognition II-41
Rapidly Growing Molecular Diagnostics II-42
New Technologies II-42
High-Definition Cell Assay Technologies: II-42
(1) Rapid, High-Definition Assays for Cellular Efficacy
(RHACE) II-42
(2) Single-Cell Analysis of Physiological Effects (SAPhE) II-42
(3) Matrix Analysis of Genomically-Indexed Cells (MAGIC) II-42

4. PRODUCT LAUNCHES II-43
Roche Introduces Roche Cardiac 200 II-43
Bio-Rad Introduces Bio-Plex Pro' II-43
IDS Introduces IDS-iSYS hGH II-43
IDS Introduces IDS-iSYS PINP II-43
IDS Introduces IDS-iSYS & IDS-iSYS Vitamin D Assay II-43
Abbott Introduces ARCHITECT c4000 Clinical Chemistry Analyzer II-44
Siemens Introduces Clinical Laboratory Automation Solutions II-44
Ortho-Clinical Diagnostics Introduces New Laboratory System II-45
Cell Biosciences Launches Kit for Analysis of Oncoproteins II-46
Roche Diagnostics Introduces Pre-Eclampsia In-Vitro Tests
across Europe II-46
Abbott To Launch New ARCHITECT® ci4100' Integrated
Immunoassay & Clinical Chemistry System II-46
Abbott Introduces ARCHITECT® i1000SR® Immunochemistry Analyzer II-47
Ortho Clinical Diagnostics Unveils Vitros® 3600
Immunodiagnostic System and Vitros® 5600 Integrated System II-47
PerkinElmer Releases New AplhaLISA' Immunoassay Diagnostic Kits II-48
Assay Designs Introduces ImmunoSet' ELISA Development Kit II-49
Trinity Biotech Introduces New Lyme Enzyme Diagnostic
Products for European Markets (Europe) II-49
bioMérieux Introduces VIDAS® NT-proBNP II-49
Beckman Coulter Introduces UniCel DxC 880i Synchron® Access® II-50



Beckman Coulter Introduces UniCel® DxI 600 II-50
bioMérieux Introduces VIDAS® B·R·A·H·M·S PCT® Assay II-50
Siemens Rolls Out ADVIA Centaur® Cyclosporine (CsA) Assay II-50
Ortho-Clinical Diagnostics Launches VITROS Troponin I ES Assay II-50
Ortho-Clinical Diagnostics Introduces VITROS® Rubella IgG Assay II-51

5. RECENT INDUSTRY ACTIVITY II-52
bioMerieux Acquires Meikang Biotech II-52
Bio-Rad Purchases Biotest AG's Diagnostics Businesses II-52
Immunodiagnostic Systems Receives FDA Approval for IDS-iSYS
Immunoassay Analyzer II-52
Roche Diagnostics Receives Immunoassay Contract from Premier
Purchasing Partner II-52
Ortho Clinical Gets US FDA Approval for Usage of VITROS®
Hepatitis B Surface Antigen (HBsAG) on VITROS® 5600
Integrated & VITROS® 3600 II-53
Neogen Takes Over International Diagnostic Systems II-53
eBioscience Acquires Bender MedSystems II-53
Inverness to Acquire ACON's Lateral Flow Immunoassay
Diagnostics Business II-54
Beckman Coulter to Purchase Olympus Corp's Diagnostics Division II-54
Instrumentation Laboratory Secures FDA Approval for ACL
AcuStarTM Hemostasis Testing System II-54
Abbott Receives FDA Premarket Approval for ARCHITECT CORE II-55
Ivax Diagnostics Inks Distribution Deal with Lin-Zhi
International II-55
Axis-Shield Inks Distribution Deals for Marketing Afinion II-55
bioMerieux and Shanghai Kehua Set Up JV II-55
bioMerieux and Quidel to Form Global Alliance for Rapid
Diagnostics II-56
Johnson & Johnson Nordic AB Takes Over Amic II-56
Roche Acquires Ventana Medical Systems, Inc. II-57
Abbott Terminates Sale Agreement with GE II-57
Abbott Inks Agreement with Premier, Inc. II-57
Beckman Coulter Renews Agreement with MedAssets II-57
Beckman Coulter Extends Agreement Amerinet II-57
Beckman Coulter Extends Partnership with Bio-Rad II-58
Siemens Acquires Dade Behring II-58
Roche Acquires BioVeris II-58
Siemens Healthcare Diagnostics Inks Agreement with Amerinet II-58
Siemens Healthcare Diagnostics Signs Agreement with Bio-Rad II-58
Siemens Medical Solutions USA Sets Up Siemens Healthcare
Diagnostics II-59

6. FOCUS ON SELECT MARKET PARTICIPANTS II-60
Abbott Laboratories (US) II-60
Beckman Coulter Inc. (US) II-60
bioMérieux (France) II-61



Bio-Rad Laboratories Inc. (US) II-61
Ortho-Clinical Diagnostics Inc (US) II-62
Roche Diagnostics (US) II-62
Siemens Healthcare Diagnostics (US) II-63

7. GLOBAL MARKET PERSPECTIVE II-64
Table 8: World Recent Past, Current & Future Analysis for
Immunoassay Systems by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific and Latin American Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2007 through 2015 (includes corresponding Graph/Chart) II-64

Table 9: World Historic Review for Immunoassay Systems by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
and Latin American Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2001 through 2006

Table 10: World 11-Year Perspective for Immunoassay Systems
by Geographic Region - Percentage Breakdown of Value Sales
for US, Canada, Japan, Europe, Asia-Pacific and Latin
American Markets for Years 2005, 2010 & 2015 (includes
Immunoassay Systems Market by Product Segment II-67
Enzyme Immunoassay Systems by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2007 through 2015 (includes corresponding
Graph/Chart) II-67

Table 12: World Historic Review for Enzyme Immunoassay Systems
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific

Table 13: World 11-Year Perspective for Enzyme Immunoassay
Systems by Geographic Region - Percentage Breakdown of Value
Sales for US, Canada, Japan, Europe, Asia-Pacific and Latin

Fluorescence Immunoassay Systems by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific and Latin American Markets



Graph/Chart) II-70

Table 15: World Historic Review for Fluorescence Immunoassay
Systems by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific and Latin American Markets Independently

Table 16: World 11-Year Perspective for Fluorescence
Immunoassay Systems by Geographic Region - Percentage
Breakdown of Value Sales for US, Canada, Japan, Europe,
Asia-Pacific and Latin American Markets for Years 2005, 2010 &
2015 (includes corresponding Graph/Chart) II-72

Chemiluminescence Immunoassay Systems by Geographic Region -
US, Canada, Japan, Europe,Asia-Pacific and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2007 through 2015 (includes

Table 18: World Historic Review for Chemiluminescence
Immunoassay Systems by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific and Latin American Markets Independently

Table 19: World 11-Year Perspective for Chemiluminescence

Radio Immunoassay Systems & Reagents by Geographic Region -
US, Canada, Japan, Europe, Asia-Pacific and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2007 through 2015 (includes

Table 21: World Historic Review for Radio Immunoassay Systems
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific

Table 22: World 11-Year Perspective for Radio Immunoassay



Sales for US, Canada, Japan, Europe, Asia-Pacific and Latin

Nephelometric Immunoassay Systems by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific and Latin American Markets
Graph/Chart) II-79

Table 24: World Historic Review for Nephelometric Immunoassay
Systems by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific and Latin American Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2001
through 2006 (includes corresponding Graph/Chart) II-80

Table 25: World 11-Year Perspective for Nephelometric

III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Market Overview III-1
Trends in the Marketplace III-1
Leading Players III-1
US In-Vitro Diagnostics Market - A Special Review III-1
Evolving Trends to Benefit IVD Market III-2
Key Statistics III-3
Table 26: US In-Vitro Diagnostics (IVD) Market (2008):
Percentage Share Breakdown of Dollar Sales by Segment
(includes corresponding Graph/Chart) III-3

Table 27: US In-Vitro Diagnostics (IVD) Market (2009):
Percentage Share Breakdown of Revenue by Leading Players
US Market for Clinical Laboratory Instruments III-3
Laboratory Consolidation and Automation on a Rise III-3
Product Launches III-4
Strategic Corporate Developments III-10
Focus on Select Players III-15
Abbott Laboratories III-15
Beckman Coulter III-15



Bio-Rad Laboratories Inc. III-16
Ortho-Clinical Diagnostics Inc III-16
Roche Diagnostics III-17
Siemens Healthcare Diagnostics III-17
B.Market Analytics III-18
Table 28: US Recent Past, Current & Future Analysis for
Immunoassay Systems by Product Segment - Enzyme Immunoassay
Systems, Fluorescence Immunoassay Systems, Chemiluminescence
Immunoassay Systems, Radio Immunoassay Systems, and
Nephelometric Immunoassay Systems Markets Independently
2007 through 2015 (includes corresponding Graph/Chart) III-18

Table 29: US Historic Review for Immunoassay Systems by
Product Segment - Enzyme Immunoassay Systems, Fluorescence
Immunoassay Systems, Chemiluminescence Immunoassay Systems,
Radio Immunoassay Systems, and Nephelometric Immunoassay
Systems Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2001 through 2006

Table 30: US 11-Year Perspective for Immunoassay Systems by
Product Segment - Percentage Breakdown of Value Sales for
Enzyme Immunoassay Systems, Fluorescence Immunoassay
Systems, Chemiluminescence Immunoassay Systems, Radio
Immunoassay Systems, and Nephelometric Immunoassay Systems
Markets for 2005, 2010 & 2015 (includes corresponding
Graph/Chart) III-20

2. CANADA III-21
Market Analysis III-21
Table 31: Canadian Recent Past, Current & Future Analysis
for Immunoassay Systems by Product Segment - Enzyme
Immunoassay Systems, Fluorescence Immunoassay Systems,
Chemiluminescence Immunoassay Systems, Radio Immunoassay
Systems, and Nephelometric Immunoassay Systems Markets
Graph/Chart) III-21

Table 32: Canadian Historic Review for Immunoassay Systems
by Product Segment - Enzyme Immunoassay Systems,
Fluorescence Immunoassay Systems, Chemiluminescence



Table 33: Canadian 11-Year Perspective for Immunoassay
Systems by Product Segment - Percentage Breakdown of Value
Sales for Enzyme Immunoassay Systems, Fluorescence
Systems Markets for 2005, 2010 & 2015 (includes
corresponding Graph/Chart) III-23

3. JAPAN III-24
Market Highlights... III-24
Strategic Corporate Development III-24
Focus on Key Players III-24
Fujirebio Inc III-24
Tosoh Corporation III-25
Table 34: Japanese Recent Past, Current & Future Analysis
Graph/Chart) III-25

Table 35: Japanese Historic Review for Immunoassay Systems

Table 36: Japanese 11-Year Perspective for Immunoassay

4. EUROPE III-28
A. Market Analytics III-28
Current & Future Analysis III-28
Overview of Immunochemistry Analyzer Market in Europe III-28
High Switching Costs and Restricted Hospital Budgets
Inhibit Market Expansion III-28
Panorama of the European Immunoassay Market III-29



Challenges III-29
Decreasing Profitability III-29
Immunodiagnostic Products Market - A Focus III-30
Trends in Immunodiagnostic Market..... III-30
IVD Market - Recent Past Perspective III-31
Table 37: European IVD Market, 2006: Leading Players by
Market Share for Roche, Dade, Abbott, Beckman, Bayer,
bioMerieux, OCD and Others (includes corresponding
Graph/Chart) III-31
Table 38: European Recent Past, Current & Future Analysis
for Immunoassay Systems by Geographic Region - France,
Germany, Italy, the UK and Rest of Europe Markets
Graph/Chart) III-33

Table 39: European Historic Review for Immunoassay Systems
by Geographic Region - France, Germany, Italy, the UK and
Rest of Europe Markets Independently Analyzed with Annual

Table 40: European Recent Past, Current & Future Analysis
Graph/Chart) III-35

Table 41: European Historic Review for Immunoassay Systems

Table 42: European 11-Year Perspective for Immunoassay
Sales for France, Germany, Italy, the UK and Rest of Europe
Markets for Years 2005, 2010 & 2015 (includes corresponding
Graph/Chart) III-37



Table 43: European 11-Year Perspective for Immunoassay
Systems Markets for Years 2005, 2010 & 2015 (includes

4a. FRANCE III-39
bioMérieux - A Key Player III-39
Table 44: French Recent Past, Current & Future Analysis for

Table 45: French Historic Review for Immunoassay Systems by

Table 46: French 11-Year Perspective for Immunoassay Systems
by Product Segment - Percentage Breakdown of Value Sales for
Graph/Chart) III-42

4b. GERMANY III-43
In-Vitro Diagnostics Market - A Snapshot III-43
Table 47: German Recent Past, Current & Future Analysis for




Table 48: German Historic Review for Immunoassay Systems by

Table 49: German 11-Year Perspective for Immunoassay Systems
by Product Segment - Percentage Breakdown of Value Sales for
Graph/Chart) III-46

4c. ITALY III-47
Table 50: Italian Recent Past, Current & Future Analysis
Graph/Chart) III-47

Table 51: Italian Historic Review for Immunoassay Systems by

Table 52: Italian 11-Year Perspective for Immunoassay

4d. THE UNITED KINGDOM III-50



IDS - A Key Player in the UK III-50
Table 53: UK Recent Past, Current & Future Analysis for

Table 54: UK Historic Review for Immunoassay Systems by

Table 55: UK 11-Year Perspective for Immunoassay Systems by
Product Segment - Percentage Breakdown of Value Sales for
Graph/Chart) III-53

4e. REST OF EUROPE III-54
Current and Future Analysis III-54
Table 56: Rest of Europe Recent Past, Current & Future
Analysis for Immunoassay Systems by Product Segment - Enzyme
Graph/Chart) III-55

Table 57: Rest of Europe Historic Review for Immunoassay
Systems by Product Segment - Enzyme Immunoassay Systems,




Table 58: Rest of Europe 11-Year Perspective for Immunoassay

5. ASIA-PACIFIC III-58
Market Highlights..... III-58
Growing In-Vitro Diagnostics (IVD) Market Fuels the Demand
for Immunoassay Instruments in Asia III-58
Review of Select Asian Markets III-58
China III-58
Chinese Market for Diagnostic Products.... III-58
Influencing Forces III-59
Market Characteristics III-59
Competitive Analysis III-59
Strategies III-60
End-User Analysis III-60
Hospitals III-60
Laboratories III-60
General Population III-61
Difficulties Posed by the Market III-61
Distribution Channels III-61
India III-61
Emerging Trends in the Indian Immunodiagnostics Market III-61
Key Statistics III-62
Table 59: Indian Immunochemistry Instruments & Reagents
Market (2009): Percentage Share Breakdown of Revenue by
Segment III-62

Table 60: Indian Immunochemistry Instruments & Reagents
Market (2009): Percentage Share Breakdown of Revenue by
Product Segment (includes corresponding Graph/Chart) III-62

Table 61: Indian Immunoassay Reagent Market (2009):
Percentage Share Breakdown of Revenue by Reagent Type
Malaysia III-63
Health Care Services.... III-63
Singapore III-64
Clinical Laboratory Equipment Market in Singapore.... III-64
Market Characteristics III-64
Imports Scene III-64



Distribution III-65
End-User Analysis III-65
Strategic Corporate Developments III-65
Table 62: Asia Pacific Recent Past, Current & Future
Graph/Chart) III-66

Table 63: Asia Pacific Historic Review for Immunoassay

Table 64: Asia Pacific 11-Year Perspective for Immunoassay

6. LATIN AMERICA III-69
Table 65: Latin American Recent Past, Current & Future
Graph/Chart) III-69

Table 66: Latin America Historic Review for Immunoassay



Table 67: Latin American 11-Year Perspective for Immunoassay

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 69 (including Divisions/Subsidiaries - 108)

------------------------------------------
Region/Country Players
------------------------------------------
The United States 48
Canada 8
Japan 11
Europe 33
France 4
Germany 9
The United Kingdom 3
Italy 4
Rest of Europe 13
Asia-Pacific (Excluding Japan) 7
Middle East 1
------------------------------------------


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