This document provides an agenda and background information for the Atlanta Summit on Health in Africa being held on May 19, 2014. The summit is a collaboration between CARE USA, the World Affairs Council of Atlanta, and the Center for Strategic and International Studies, and will examine strengthening U.S. leadership in global health and Africa's unfinished health agenda. The all-day event will include welcoming and framing remarks, panels on opportunities for progress and policy frameworks, and a keynote speech. Participation in the summit supports collaboration to advance global health.