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Maintains blood volume
Balance of water, electrolytes
pH balance
Retains key substances (glucose)
Removes wastes
Produces 90% of erythropoietin
https://www.youtube.com/watch?v=l128tW
1H5a8
Cellular metabolism produces ammonia.
Ammonia is converted to urea (in liver).
Urea is filtered by kidneys and turned into
urine.
1 million nephrons
10 % per decade lost after age 40
Consists of cortex and medulla
Forms urine
Functional unit of kidney
Surrounded by complex net of capillaries
Glomerulus (surrounded by Bowman’s
Capsule)
Proximal tubule
Descending loop of Henle
Ascending loop of Henle
Distal tubule
Collecting duct
Glomular filtration
Reabsorption
Secretion
Glucose normally reabsorbed via active
transport before filtrate enters proximal
tubule
BgL > 180 mg/dL results in spilling of
glucose
Molecule is very small
Is passively reabsorbed
Only about ½ remains in urine
BUN – Blood Urea Nitrogen test measures
amount in blood
Creatinine- another waste is too large to
be reabsorbed
Urine output 0.5-1 mL/kg/hr
Urine ph 5 – 9 (higher = UTI)
Creatinine level 0.6 – 1.4 mg/dL
BUN 8-25 mg/dL
Enzyme produced by kidney cells
Produces Angiotensin I
Angiotensin I is converted to II by
Angiotensin Concerting Enzyme (ACE)
Angiotensin II is vasoconstrictor
Ureters
Bladder
Urethra
Testes
Prostate Gland (surrounds bladder neck)
• Makes the fluid that sperm combines with
Visceral- arises from hollow organs…
achy, crampy… Poorly localized
Somatic pain- localized
Referred pain-felt in location other than
site of origin
Antibiotics
• Cipro
• Keflex
• Bactrim
• Levaquin
Pain medication
• Pyridium
Over the counter1
Also called Acute Renal Injury
Sudden drop in urine output < 500 mL per
day (Oliguria)
Anuria – no urine output
Dysfunction before level of kidney
Insufficient blood supply
Most common cause of ARF
Often reversible
Hemorrhage, heart failure, sepsis, shock
Injury to small blood vessels or glomerular
capillaries
Injury to tubular cells
Inflammation or infection
Type I diabetes
Distal to kidney
Urine backs up and shuts down kidneys
All forms of acute renal injury
(acute renal failure) can lead to
hyperkalemia, metabolic acidosis,
and uremia.
Permanent loss of nephrons
70% lost before problems develop
End-stage renal failure needs transplant or
dialysis
Hypertension and Diabetes
Shunt (fistula)- Combined vein and artery
Blood is filtered 300- 400 mL/min
Fistula should have a vibration or thrill
Hypotension
Chest pain
Dysrythmias
Hyperkalemia
Hemorrhage
Sepsis
Seizures
Air embolism
Pericarditis
http://www.esrdnet5.org/Files/Education/M
eetings---
Presentations/Complications_Dialysis-12-
09-(1).aspx
http://www.youtube.com/watch?v=toFiGSfe
sZk
Bleeding
Infection
Narrowing fistula- may lead to thrombosis
Chronic ambulatory peritoneal dialysis
Risk of fluid shifts
Infection
Peritonitis
(Pictures too gross)
Hydoxyzine
Calcium Channel blockers
Anticoagulants
Cocaine
Marijuana
MDMA
Phimosis- inability to retract foreskin
Paraphimosis- foreskin retracted and glans
penis becomes entrapped
Benign Prostate Hypertrophy-
noncancerous enlargement
Testicular masses

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