This document provides an overview of the Generative Models School V3.0 Hybrid Edition hosted by Andrey Ustyuzhanin from HSE University from November 23-26, 2021. The school will cover topics ranging from the basics of machine learning to cutting-edge applications and beyond, using examples from high-energy physics. It will focus on formulating physics problems in machine-learning terms, selecting quality criteria, and applying techniques like boosting, bagging, neural networks. Participants will learn to design experiments and optimize models. The school aims to provide an interactive learning experience with lectures, assignments, seminars and social activities.